Angiotensin II receptor antagonist TCV-116 induces regression of hypertensive left ventricular hypertrophy in vivo and inhibits the intracellular signaling pathway of stretch-mediated cardiomyocyte hypertrophy in vitro

Circulation

Volumn 89, Issue 5, 1994, Pages 2204-2211

  Kojima, M ^a   Shiojima, I ^a   Yamazaki, T ^a   Komuro, I ^a   Yunzeng, Z ^a   Ying, W ^a   Mizuno, T ^a   Ueki, K ^a   Tobe, K ^a   Kadowaki, T ^a   Nagai, R ^a   Yazaki, Y ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

hypertension; hypertrophy; pressure overload; renin angiotensin system

Indexed keywords

2 ETHOXY 1 [2' (1H TETRAZOL 5 YL)BIPHENYL 4 YL] 1H BENZIMIDAZOLE 7 CARBOXYLIC ACID; ANGIOTENSIN; ANGIOTENSIN ANTAGONIST; ANGIOTENSIN RECEPTOR; CANDESARTAN; CANDESARTAN HEXETIL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HYDRALAZINE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MYOSIN HEAVY CHAIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; ENZYME ACTIVITY; HEART LEFT VENTRICLE HYPERTROPHY; HEART MUSCLE CELL; HYPERTENSION; INTRAGASTRIC DRUG ADMINISTRATION; MALE; MUSCLE STRETCHING; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SPONTANEOUSLY HYPERTENSIVE RAT;

EID: 0028206850     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.89.5.2204     Document Type: Article

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