Attachment of oligosaccharides to peptide antigen profoundly affects binding to major histocompatibility complex class II molecules and peptide immunogenicity

European Journal of Immunology

Volumn 24, Issue 5, 1994, Pages 1066-1072

  Mouritsen, Søren ^a,b   Meldal, Morten ^c   Christiansen‐Brams, Ida ^c   Elsner, Henrik ^a   Werdelin, Ole ^b  

^a University of Copenhagen ^*  (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c CARLSBERG LABORATORY   (Denmark)

Author keywords

Glycopeptide; Glycopeptide binding to MHC; Glycopeptide epitope; Glycopeptide immunogenicity; Heteroclitic response to glycopeptide

Indexed keywords

ASPARAGINE; EPITOPE; GLYCOPEPTIDE; LYSOZYME; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; N ACETYLGLUCOSAMINE; OLIGOSACCHARIDE; PEPTIDE FRAGMENT; SERINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN BINDING; ARTICLE; CIRCULAR DICHROISM; GLYCOSYLATION; H2 SYSTEM; IMMUNIZATION; IMMUNOGENICITY; LYMPHOCYTE PROLIFERATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; T LYMPHOCYTE;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS; BINDING, COMPETITIVE; CARBOHYDRATE SEQUENCE; CIRCULAR DICHROISM; GLYCOPEPTIDES; HISTOCOMPATIBILITY ANTIGENS CLASS II; LYMPHOCYTE ACTIVATION; MICE; MOLECULAR SEQUENCE DATA; OLIGOSACCHARIDES; PEPTIDE FRAGMENTS; PROTEIN BINDING;

EID: 0028206748     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.1830240509     Document Type: Article

References (27)

1. Protected-mode synthesis of N-linked glycopeptides: single-step preparation of building blocks as peracetyl glycosylated N ?Fmoc asparagine OPfp esters
2. Peptide synthesis. Part 13. Feedback control in solid phase synthesis. Use of fluorenylmethoxycarbonyl amino acid 3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl esters in a fully automated system