Hormonal signaling and regulation of salt and water transport in the collecting duct

Annual Review of Physiology

Volumn 56, Issue , 1994, Pages 711-739

  Breyer, Matthew D ^a   Ando, Yasuhiro ^b  

^a VANDERBILT UNIVERSITY   (United States)

^b JICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

calcium; cyclic AMP; protein kinase C; sodium; vasopressin

Indexed keywords

CALCIUM; CYCLIC AMP; PROTEIN KINASE C; VASOPRESSIN;

KIDNEY COLLECTING TUBULE; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; WATER TRANSPORT;

EID: 0028206667     PISSN: 00664278     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.ph.56.030194.003431     Document Type: Review

References (223)

1. Abramow M, Beauwens R, Cogan E. 1987. Cellular events in vasopressin action. Kidney Int. 32:856-66
2. Aiyar N, Nambi P, Stassen FL, Crooke ST. 1986. Vascular vasopressin receptors mediate phosphatidylinositol turnover and calcium efflux in an established smooth muscle cell line. Life Sci. 39:37-45
3. Ammar A, Roseau S, Butlen D. 1992. Pharmacological characterization of Via vasopressin receptors in the cortical collecting duct. Am. J. Physiol. 262:F546-53
4. Anderson RJ, Berl T, McDonald KM, Schrier RW. 1975. Evidence for an in vitro antagonism between vasopressin and prostaglandin in the mammalian kidney. J. Clin. Invest. 56:420-26
5. Ando Y, Asano Y. 1993. Functional evidence for an apical VI receptor in the rabbit cortical collecting duct. Am. J. Physiol. 264:F467-71
6. Ando Y, Jacobson H, Breyer M. 1989. Does cyclic AMP-dependent protein kinase (PKA) mediate the hydroosmotic effect of vasopressin (AVP) in rabbit cortical collecting duct (CCD)? Kidney Int. 37:576 (Abstr.)
7. Ando Y, Jacobson HR, Breyer MD. 1987. Phorbol myristate acetate, dioctanoylglycerol, and phosphatidic acid inhibit the hydroosmotic effect of vasopressin on rabbit cortical collecting tubule. J. Clin. Invest. 80:590-93
8. Ando Y, Jacobson HR, Breyer MD. 1988. Phorbol ester and A23187 have additive but mechanistically separate effects on vasopressin action in rabbit cortical collecting tubule. J. Clin. Invest. 81:1578-84
9. Ando Y, Jacobson HR, Breyer MD. 1989. Phosphatidic acids inhibit vaso-pressin-induced water transport via protein kinase C activation. Am. J. Physiol. 257:F524-30
10. Ando Y, Tabei K, Asano. Y. 1991. Luminal vasopressin modulates transport in the rabbit cortical collecting duct. J. Clin. Invest. 88:952-59
11. Aramori I, Nakamshi S. 1992. Coupling of two endothelin receptor subtypes to differing signal transduction in transfected Chinese hamster ovary cells. J. Biol. Chem. 267(18):12468-74
12. Augert G, Bocckino SB, Blackmore PF, Exton JH. 1989. Hormonal stimulation of diacylglycerol formation in hepatocytes:evidence for phosphatidylcholine breakdown. J. Biol. Chem. 264(36):21689-98
13. Ausiello DA, Hall D. 1981. Regulation of vasopressin sensitive adenylate cyclase by calmodulin. J. Biol. Chem. 256:9796-98
14. Axelrod J. 1990. Receptor-mediated activation of phospholipase A2 and arachidonic acid release in signal transduction. Biochem. Soc. Trans. 18(4):503-7
15. Beavo JA, Reifsnyder DH. 1990. Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors. Trends Pharmacol. Sci. 11:150-55
16. Beebe SJ, Blackmore BF, Chrisman TD, Corbin JD. 1988. Use of synergistic pairs of site-selective cAMP analogs in intact cells. In Methods in Enzymology:Initiation and Termination of Cyclic Nucleotide Action, ed. JD Corbin, RA Johnson, pp. 118-39. New York:Academic
17. Benos DJ, Saccomani G, Sariban-Sohraby S. 1987. The epithelial sodium channel:subunit number and location of amiloride binding site. J. Biol. Chem. 262:10613-18
18. Bentley JK, Kadlecek A, Sherbert CH, Seger D, Sonnenburg WK, et al. 1992. Molecular cloning of cDNA encoding a 63-kDa calmodulin-stimulated phosphodiesterase from bovine brain. J. Biol. Chem. 267:18676-82
19. α. Cell 68:911-22
20. Berridge MJ. 1993. Inositol trisphosphate and calcium signalling. Nature 361:315-25
21. +-ATPase inhibits the activity of the enzyme. Proc. Natl. Acad. Sci. USA 88:11359-62
22. Birnbaumer M, Seibold A, Gilbert S, Ishido M, Barberis C, et al. 1992. Molecular cloning of the receptor for human antidiuretic hormone. Nature 357:333-35
23. 22a. Birnbaumer L. 1992. Receptor-to-effector signaling through G proteins:Roles for βγ dimers as well as α subunits. Cell 71:1069-72
24. Bishop WR, Bell RM. 1988. Assembly of phospholipids into cellular membranes:biosynthesis, transmembrane movement and intracellular translocation. Annu. Rev. Cell Biol. 4:579-610
25. Bocckino SB, Blakemore PF, Wilson PB, Exton JH. 1987. Phosphatidate accumulation in hormone-treated hepatocytes via a phospholipase D mechanism. J. Biol. Chem. 262:15309-15
26. Bonvalet JP, Pradelles P, Farman N. 1987. Segmental synthesis and actions of prostaglandins along the nephron. Am. J. Physiol. 253:F377-87
27. Bonventre JV. 1992. Phospholipase A2 and signal transduction. J. Am. Soc. Nephrol. 3(2):128-150
28. Bourdeau JE, Lau K. 1990. Basolateral cell membrane Ca-Na exchange in single rabbit connecting tubules. Am. J. Physiol. 258:F1497-1503
29. 2+ entry. J. Clin. Invest. 88:1502-10
30. Breyer MD. 1991. Regulation of water and salt transport in collecting duct through calcium-dependent signaling mechanisms. Am. J. Physiol. 260:F1-F11
31. +]) in the rabbit cortical collecting duct (CCD). J. Am. Soc. Nephrol. 2(3):732 (abs(ract)
32. Breyer MD, Jacobson HR, Breyer JA. 1988. Epidermal growth factor inhibits the hydroosmotic effect of vasopressin in the isolated perfused rabbit cortical collecting tubule. J. Clin. Invest. 82:1313-20
33. Brown D. 1989. Membrane recycling and epithelial cell function. Am. J. Physiol. 256:F1-12
34. Brown D, Orci L. 1983. Vasopressin stimulates formation of coated pits in rat kidney collecting ducts. Nature 302:253-55
35. Brunskill N, Bastani B, Hayes C, Morrissey J, Klahr S. 1991. Localization and polar distribution of several G-protein subunits along nephron segments. Kidney Int. 40:997-1006
36. Burnatowska-Hledin MA, Spielman WS. 1988. Immunodissection of mitochondria-rich cells from rabbit outer medullary collecting tubule. Am. J. Physiol. 254:F907-11
37. Burnatowska-Hledin MA, Spielman WS. 1989. Vasopressin V1 receptors on the principal cells of the rabbit cortical collecting tubule:stimulation of cytosolic free calcium and inositol phosphate production via coupling to a pertussis toxin substrate. J. Clin. Invest. 83:84-89
38. Canessa CM, Horisberger J-D, Rossier BC. 1993. Epithelial sodium channel related to proteins involved in neurodegeneration. Nature 361:467-70
39. + channels by activation of phospholipase A2 and lipoxygenase pathways. J. Biol. Chem. 265:21624-28
40. + channel activity. Am. J. Physiol. 261:C882-88
41. Carpenter G, Cohen S. 1990. Epidermal growth factor. J. Biol. Chem. 265(14):7709-12
42. Carr DW, Stofko-Hahn RE, Fraser IDC, Cone RD, Scott JD. 1992. Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-Kinase anchoring proteins:characterization of AKAP 79. J. Biol. Chem. 267:16816-23
43. + and water transport in rat and rabbit CCD. Am. J. Physiol. 261:F126-136
44. Chilablin AV, Vasilates LA, Hennekes H, Pralong D, Geering K. 1992. Phosphorylation of Na,K-ATPase α-subunits in microsomes and in homogenates of Xenopus oocytes resuting from the stimulation of protein kinase A and protein kinase C. J. Biol. Chem. 267(31):22378-84
45. 2+-dependent translocation domain with homology to PKC and GAP. Cell 65:1043-51
46. Coffey AK, O'Sullivan DJ, Homma S, Dousa TP, Valtin H. 1991. induction of intramembranous particle clusters in mice with nephrogenic diabetes insipidus. Am. J. Physiol. 261:F640-46
47. Conklin BR, Chabre O, Wong YH, Federman AD, Bourne HR. 1992. Recombinant Gqα. J. Biol. Chem. 267:31-34
48. Cort JH., Schück O, Stribrna J, Skopkova J, Jost K, Mulder JL. 1975. Role of the disulfide bridge and the C-terminal tripeptide in the antidiuretic action of vasopressin in man and the rat. Kidney Int. 8:292-302
49. Ding G, McGovern B, Singhai P, Hays RM. 1989. Aggrephores have little, if any role in water channel delivery in rat collecting duct. Kidney Int. 35:305
50. Dixon BS, Breckon R, Burke C, Anderson RJ. 1988. Phorbol esters inhibit adenylate cyclase activity in cultured collecting tubular cells. Am. J. Physiol. 254:C183-91
51. Dong L, Stevens JL, Jaken S. 1991. Biochemical and immunological characterization of renal protein kinase C. Am. J. Physiol. 261:F678-87
52. Doucet A, Barlet C. 1986. Evidence for differences in the sensitivity to ouabain of Na/K-ATPase along the nephrons of rabbit kidney. J. Biol. Chem. 261:993-95
53. Dousa TP, Valtin H. 1976. Cellular actions of vasopressin in the mammalian kidney. Kidney Int. 10:46-63
54. Edwards RM, Jackson BA, Dousa TP. 1980. Protein kinase activity in isolated tubules of rat medulla. Am. J. Physiol. 238:F269-78
55. Emanuel JR, Garetz S, Sone L, Levenson R. 1987. Differential expression of Na-K-ATPase alpha and beta subunit mRNAs in rat tissues and cell lines. Proc. Natl. Acat. Sci. USA 84:9030-34
56. Exton JH. 1990. Signaling through phosphatidylcholine breakdown. J. Biol. Chem. 265(1):1-4
57. Fejes-Tóth G, Náray-Fejes-Tóth A. 1987. Differentiated transport functions in primary cultures of rabbil collecting ducts. Am. J. Physiol. 253:F1302-7
58. Fejes-Tóth G, Náray-Fejes-Tóth A. 1992. Differentiation of β-intercalated cells (β-ICC) in culture into α-ICC and principal cells (PC) via asymmetric cell division. J. Am. Soc. Nephrol. 3:838 (Abstr.)
59. Fejes-Tóth G, Zahajszky T, Filep J. 1980. Effect of vasopressin on kallikrein excretion. Am. J. Physiol. 239:F388-92
60. Ferris CD, Huganir RL, Supattapone S, Snyder SH. 1989. Purified inositol 1,4,5-trisphosphate receptor mediates calcium flux in reconstituted lipid vesicles. Nature 342:87-89
61. Field MF, Stanton BA, Giebisch GH 1984. Influence of ADH on renal potassium handling:a micropuncture and microperfusion study. Kidney Int. 25:502-11
62. Frindt G. Burg MB. 1972. Effect of vasopressin on sodium transport in renal cortical collecting tubules. Kidney Int. 1:224-31
63. 2+-dependent inhibition of sodium transport in rabbit cortical collecting tubules. Am. J. Physiol. 258:F568-82
64. Fushimi K, Uchuda S, Hara Y, Hirata Y, Marumo F, Sasaki S. 1993. Cloning and expression of apical membrane water channel of rat kidney collecting tubule. Nature 361:549-52
65. Gamba G, Saltzberg SN, Lombardi M, Miyanoshita A, Lytton J, et al. 1993. Primary structure and functional expression of a cDNA encoding the thiazide-sensitive, electroneutral sodium-chloride cotransporter. Proc. Natl. Acad. Sci. USA 90:2749-53
66. Gapstur SM, Homma S, Dousa TP. 1988. cAMP-binding proteins in medullary tubules from rat kidney:effect of ADH. Am. J. Physiol. 255:F292-300
67. Garcia-Perez A, Smith WL. 1984. Apical-basolateral membrane asymmetry in canine cortical collecting tubule cells. J. Clin. Invest. 74:63-74
68. Garg LC. 1992. Actions of adrenergic and cholinergic drugs on renal tubular cells. Pharmacol. Rev. 44(1):81-102
69. Glatt CE, Snyder SH. 1993. Cloning and expression of an adenylyl cyclase localized to the corpus striatum. Nature 361:536-38
70. Goldschmidt-Clermont P, Kim JW, Machesky LM, Rhee SG, Pollard TD. 1991. Regulation of phospholipase C-γ1 by profilin and tyrosine phosphorylation. Science 251:1231-33
71. Grantham JJ, Burg MB. 1966. Effect of vasopressin and cyclic AMP on permeability of isolated collecting tubules. Am. J. Physiol. 211:255-59
72. Gupta SK, Diez E, Heasley LE, Osawa S, Johnson GL. 1990. A G protein mutant that inhibits thrombin and purinergic receptor activation of phospholipase A2. Science 249:662-66
73. Man JS, Maeda Y, Knepper MA. 1992. High concentration of vasopressin inhibit vasopressin-stimulated water transport in rat terminal IMCD. J. Am. Soc. Nephrol. 3:793 (Abstr.)
74. Hardy MA. 1978. Intracellular calcium as a modulator of Iransepithelial permeability to water in frog urinary bladder. J. Cell Biol. 76:787-91
75. Harris HW, Strange K, Zeidel ML. 1991. Current understanding of the cellular biology and molecular structure of the antidiuretic hormone-stimulated water transport pathway. J. Clin. Invest. 88:1-8
76. Harrison JK, Hewlett KGH, Gnegy ME. 1989. Regulation of calmodulin-sensitive adenylate cyclase by the stimulatory G-protein, Gsα. J. Biol. Chem. 264:15880-85
77. Hartwig JH, Thelen M, Rosen A, Janmey PA, Nairn AC, Aderem A. 1992. MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium-calmodulin. Nature 356:618-22
78. Hays RM. 1991. Cell biology of vasopressin. In The Kidney, ed. BM Brenner, FC Rector, pp. 424-44. Philadelphia:Saunders
79. 2 transport in the rabbit cortical collecting tubule. J. Clin. Invest. 80:1561-70
80. Hebert RL, Jacobson HR, Breyer MD. 1991. Prostaglandin E2 inhibits sodium transport in the rabbit CCD by raising intracellular calcium. J. Clin. Invest. 87:1992-98
81. Hebert RL, Jukic D, Regoli D. 1992. Mediation of bradykinin (BDK) actions in rabbit cortical collecting duct (CCD) via a specific BDK-B2 receptor. J. Am. Soc. Nephrol. 3(3):493
82. Ho K, Nichols CG, Lederer WJ, Lytton J, Vassilev PM, et al. 1993. Cloning and expression of an inwardly rectifying ATP-regulated potassium channel. Nature 362:31-38
83. Holmgren K, Mugnusson K-E, Franki N, Hays RM. 1992. ADH-induced depolymerization of F-actin in the toad bladder granular cell:a confocal microscope study. Am. J. Physiol. 262:C672-77
84. Holt WF, LeChene C. 1981. ADH-PGE2 interactions in cortical collecting tubule. I. Depression of sodium transport. Am. J. Physiol. 241:F452-60
85. Homma S, Gapstur SM, Coffey A, Valtin H, Dousa TP. 1991. Role of cAMP-phosphodiesterase isozymes in pathogenesis of murine nephrogenic diabetes insipidus. Am. J. Physiol. 261:F345-53
86. Homma S, Gapstur SM, Yusufi ANK, Dousa TP. 1988. In situ phosphorylation of proteins in MCTs micro-dissected from rat kidney:effect of AVP. Am. J. Physiol. 254:F512-20
87. m cAMP phosphodiesterase (PDE) in medullary collecting ducts (MCD). J. Am. Soc. Nephrol. 2:723
88. Huang C, Cabot MC. 1990. Vasopressin-induced polyphosphoinositide and phosphatidylcholine degradation in fibroblasts. J. Biol. Chem. 265:17468-73
89. Irvine RF. 1982. How is the level of free arachidonic acid controlled in mammalian cells? Biochem. J. 204:3-16
90. Ishikawa S, Saito T. 1990. Optimal concentration of cellular free calcium for AVP-induced cAMP in collecting tubules. Kidney Int. 37:1060-66
91. +-ATPase activity in the inner medullary collecting duct. Am. J. Physiol. (257):F424-F430
92. Jassier F, Bugeon L, Blot-Chabaud M, Bonvalet JP, Farman N. 1989. Effects of AVP and dDAVP on PGE2 synthesis in superfused cortical collecting tubules. Am. J. Physiol. 256:F1044-50
93. m rolipram-sensitive cAMP phosphodiesterase. J. Biol. Chem. 267:18929-39
94. Jones SM, Frindt G. Windhager EE. 1988. Effect of peritubular [Ca] or ionomycin on hydrosmotic response of CCTs to ADH or cAMP. Am. J. Physiol. 254:F240-53
95. Kashgarian M, Diemsderfer D, Caplan M, Forbush B. 1985. Monoclonal antibody to Na,K-ATPase:immunocyto-chemical localization along nephron segements. Kidney Int. 28:899-913
96. Katsushika S, Chen L, Kawabe J-I, Nilakantan R, Halnon NJ, et al. 1992. Cloning and characterization of a sixth adenylyl cyclase isoform:Types V and VI constitute a subgroup within the mammalian adenylyl cyclase family. Proc. Natl. Acad. Sci. USA 89:8774-78
97. 3 receptor:localization to plasma membrane of T cells and cocapping with the T cell receptor. Science 257:815-18
98. Kimura T, Share L. 1981. Characterization of the renal handling of vasopressin in the dog by stop-flow analysis. Endocrinology. 109:2089-94
99. Kirk KL. 1988. Binding and internalization of a fluorescent vasopressin analogue by collecting duct cells. Am. J. Physiol. 255:C622-32
100. Kirk KL. 1988. Origin of ADH-induced vacuoles in rabbit cortical collecting tubule. Am. J. Physiol. 254:F719-33
101. + channel antibody raised by an antiidiotypic route. J. Biol. Chem. 266(6):3907-15
102. Knepper MA, Lankford SP, Tereda Y. 1991. Renal tubular actions of ANF. Can. J. Physiol. Pharmacol. 69:1537-45
103. Knepper MA, Star RA. 1990. The vasopressin-regulated urea transporter in renal inner medullary collecting duct. Am. J. Physiol. 259:F393-401
104. Kosaka Y, Ogita K, Ase K, Nomura H, Kikkawa U, Nishizuka Y. 1988. The heterogeneity of protein kinase C in various rat tissues. Biochem. Biophys. Res. Comm. 151:973-81
105. Krupinski J, Lehman TC, Frankenfield CD, Zwaagstra JC, Watson PA. 1992. Molecular diversity in the adenyly-cyclase family:evidence for eight forms of the enzyme and cloning of type VI. J. Biol. Chem. 267(34):24858-62
106. Kusano E, Murayama N, Werness JL, Christensen S, Homma S, et al. 1985. Effects of calcium on the vasopressin-sensitive cAMP metabolism in medullary tubules. Am. J. Physiol. 249:F956-66
107. Leaf A, Anderson J, Page LB. 1958. Active sodium transport by the isolated toad bladder. J. Gen. Physiol. 41:657-68
108. Lefurgey A, Tisher CC. 1979. Morphology of the rabbit collecting tubule. Am. J. Anat. 155:111-24
109. Leite JM, Rouse D, Lederer E, Abramowitz J, Suki WN. 1991. TMB-8 prevents the hydroosmotic response to ADH in rabbit cortical collecting tubules. Kidney Int. 40:434-40
110. 2+ in vasopressin-stimulated insulin-secreting RINm5F cells. J. Biol. Chem. 267:4349-56
111. Light DB, Corbin JD, Stanton BA. 1990. Dual ion-channel regulation by cyclic GMP and cyclic-GMP dependent protein kinase. Nature 344:336-39
112. Lin L-L, Wartmann M, Lin AY, Knopf JL, Seth A, Davis RJ. 1993. cPLA2 is phosphorylated and activated by MAP kinase. Cell 72:269-78
113. Lin M, Nairn AC, Guggino SE. 1992. cGMP-dependent protein kinase regulation of a chloride channel in T-84 cells. Am. J. Physiol. 262:C1304-12
114. Ling BN, Hinton CF, Eaton DC. 1991. Potassium permeable channels in primary cultures of rabbit cortical collecting tubule. Kidney Int. 40:441-52
115. + channels in rabbit cortical collecting tubules by basolateral prostaglandin E2 is modulated by protein kinase C. J. Clin. Invest. 90:1328-34
116. + channel. FEBS Lett. 318:95-99
117. Lolait SJ, O'Carrol A-M, McBride OW, Konig M, Morel A, Brownstein MJ. 1992. Cloning and characterization of a vasopressin V2 receptor and possible link to nephrogenic diabetes insipidus. Nature 357:336-39
118. Ludwig J, Margalit T, Eismann E, Lancet D, Kaupp UB. 1990. Primary structure of cAMP-gated channel from bovine olfactory epithelium. FEBS Lett. 270:24-29
119. Madsen KM, Tisher CC. 1986. Structure function relationships along the distal nephron. Am. J. Physiol. 250 (19):F1-15
120. Manganiello VC, Smith CJ, Degerman E, Beifrage P. 1990. Cyclic GMP-inhibited cyclic nucleotide phosphodieterases. In Cyclic Nucleotide Phosphodiesterases:Structure, Regulation and Drug Action, ed. J Beavo, MD Houslay, pp. 87-116. New York:Wiley & Sons
121. Marunaka Y, Eaton DC. 1991. Effects of vasopressin and cAMP on single amiloride-blockable Na channels. Am. J. Physiol. 260:C1071-84
122. Masur SK, Sapirstein V, Rivero D. 1985. Phorbol myristate acetate induces endocytosis as well as exocytosis and hydroosmosis in toad urinary bladder. Biochem. Biophys. Acta. 821:286-96
123. Miller M, Moses AM. 1972. Urinary antidiuretic hormone in polyuric disorders and in inappropriate ADH syndrome. Ann. Intern. Med. 77:715-21
124. Miller RT. 1991. Transmembrane signalling through G proteins. Kidney Int. 39:421-29
125. Morel A, O'Carroll A-M, Brownstein MJ, Lolait SJ. 1992. Molecular cloning and expression of a rat Via arginine vasopressin receptor. Nature 356:523-26
126. Morel F, Doucet A. 1986. Hormonal control of kidney functions at the cell level. Physiol. Rev. 66:377-468126.
127. Moriarty TM, Padrell E, Carty DJ, Omri G, Landau EM, Iyengar R. 1990. Go protein as signal transducer in the pertussis toxin-sensitive phosphatidylinositol pathway. Nature 343:79-82
128. Moses A, Steciak E. 1986. Urinary and metabolic clearances of arginine vasopressin in normal subjects. Am. J. Physiol. 251:R365-70
129. Muller J, Kachadorian WA, DiScala VA. 1980. Evidence that ADH-stimulated intramembranous particle aggregates are transfered from cytoplasmic to luminal membranes in toad bladder epithelial cells. J. Cell Biol. 85:83-95
130. Murayama T, Ui M. 1983. Loss of the inhibitory function of the guanine nucleotide regulatory component of adenylate cyclase due to its ADP ribosylation by islet-activating protein, pertussis toxin, in adipocyte membranes. J. Biol. Chem. 258:3319-26
131. Nadler SP, Zimpelmann JA, Hebert RL. 1992. Endothelin inhibits vasorpessin-stimulated water permeability in rat terminal inner medullary collecting duct. J. Clin. Invest. 90:1458-66
132. Nagamine Y, Reich E. 1985. Gene expression and cAMP. Proc Natl. Acad. Sci. USA 82:4606-10
133. Nakamura T, Gold GH. 1987. A cyclic nucleotide-gated conductance in olfactory receptor cilia. Nature 325:442-44
134. Natochin YV, Shakhmatova EI. 1992. Vasopressin VI-antagonist increases the hydroosmotic response to arginine vasopressin in frog urinary bladder. Pflügers Arch. 421:406-8
135. Nemenoff RA, Sinitz S, Qian N-X, Van Putten V, Johnson GL, Heasley LE. 1993. Phosphorylation and activation of a high molecular weight form of phospholipase A2 by p42 microtubule-associated protein 2 kinase and protein kinase C. J. Biol. Chem. 268(3):1960-64
136. Nesterova MV, Glukhov AI, Severin ES. 1982. Effect of regulatory subunit of cAMP-dependent protein kinase on the genetic activity of eukaryotic cells. Mol. Cell. Biochem. 49:53-61
137. Nishizuka Y. 1992. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258:607-14
138. Nonoguchi H, Sands JM, Knepper MA. 1988. Atrial natriuretic factor inhibits vasopressin-stimulated osmotic water permeability in rat inner medullary collecting duct. J. Clin. Invest. 82:1383-90
139. Nonoguchi HM, Knepper MA, Manganiello VC. 1987. Effects of atrial natriuretic factor on cyclic guanosine monophosphate and cyclic adenosine monophosphate accumulation in micro-dissected nephron segments from rats. J. Clin. Invest. 79:500-7
140. Ohuchi K, Levine L. 1978. Stimulation of prostaglandin synthesis by tumor promoting phorbol-12,13-diesters in canine kidney (MDCK) cells. J. Biol. Chem. 253:4783-90
141. O'Neil RG, Hayhurst RH. 1985. Functional differentiation of cell types of the cortical collecting duct. Am. J. Physiol. 248:F449-53
142. Orioff J, Handler JS. 1962. The similarity of effects of vasopressin, adenosine-3′,5′-phosphate (cyclic AMP) and theophylline on the toad bladder. J. Clin. Invest. 41:702-9
143. Palmer LG. 1992. Epithelial Na channels:function and diversity. Annu. Rev. Physiol. 54:51-66
144. Palmer LG, Frindt G. 1986. Amiloride-sensitive Na channels from the apical membrane of the rat cortical collecting tubule. Proc. Natl. Acad. Sci. USA 83:2767-70
145. Palmer LG, Frindt G. 1987. Effects of cell Ca and pH on Na channels from rat cortical collecting tubule. Am. J. Physiol. 253:F333-39
146. Pelech SL, Sanghera JS. 1992. MAP kinases:charting the regulatory pathways. Science 257:1355-56)
147. Peterson MW, Walter ME. 1992. Calcium-activated phosphatidylcholine-specific phospholipase C and D in MDCK epithelial cells. Am. J. Physiol. 263:C1216-24
148. Phillips ME, Taylor A. 1989. Effect of nocodazole on the water permeability response to vasopressin in rabbit collecting tubules perfused in vitro. J. Physiol. 411:529-44
149. Premont RT, Chen J, Ma H-W, Ponnapalli M, Iyengar R. 1992. Two members of a widely expressed sub-family of hormone-stimulated adenylyl cyclases. Proc. Natl. Acad. Sci. USA 89:9809-13
150. Preston BM, Agre P. 1991. Isolation of the cDNA for erythrocyte integral membrane protein of 28 kilodaltons:member of an ancient channel family. Proc. Natl. Acad. Sci. USA 88:11110-14
151. Preston BM, Carroll TP, Guggino WB, Agre P. 1992. Appearance of water channels in Xenopus oocytes expressing red cell CHIP28 protein. Science 256:385-87
152. Rabkin R, Share L, Payne PA, Young J, Crofton J. 1979. The handling of immunoreactive vasopressin by the isolated perfused rat kidney. J. Clin. Invest. 63:6-13
153. Reif MC, Troutman SL, Schafer JA. 1984. Sustained response to vasopressin in isolated rat cortical collecting tubule. Kidney Int. 26:725-32
154. Repaske DR, Swinnen JV, Jin S-LC, Van Wyk JJ, Conti M. 1992. A polymerase chain reaction strategy to identify and clone cyclic nucleotide phosphodiesterase cDNAs. J. Biol. Chem. 267:18683-88
155. Rhee SG, Choi KD. 1992. Regulation of inositol phospholipid-specific phospholipase C isozymes. J. Biol. Chem. 267(18):12393-96
156. Ribeiro C-P, Ribeiro-Neto F, Field JB, Suki WN. 1987. Prevention of α2-adrenergic inhibition on ADH action by pertussis toxin in rabbit CCT. Am. J. Physiol. 253:C105-12
157. Rick R, Spancken G. Dorge A. 1988. Differential effects of aldosterone and ADH on intracellular electrolytes in the toad urinary bladder epithelium. J. Membr. Biol. 101:275-82
158. Robertson GL. 1977. The regulation of vasopressin function in health and disease. Recent Prog. Horm. Res. 33:333-85
159. Rocha AS, Kudo LH. 1990. Atrial peptide and cGMP effects on NaCl transport in inner medullary collecting duct. Am. J. Physiol. 259:F258-68
160. Rocha AS, Kudo LH. 1990. Effect of atrial natriuretic factor and cyclic guanosinc monophosphate on water and urea transport in the inner medullary collecting duct. Pflügers Arch. 417:84-90
161. 2O transport in the rat cortical collecting duct (CCD). J. Am. Soc. Nephrol. 2:740 (Abstr.)
162. + transport in isolated rat CCD:effects of bradykinin, ANP, clonidine, and hydrochlorothia-zide. Am. J. Physiol. 260:F86-95
163. Sabolic I, Valenti G, Verbavatz J-M, Van Hoek AN, Verkman AS, et al. 1992. Localization of the CHIP28 water channel in rat kidney. Am. J. Physiol. 263:C1225-33
164. Sariban-Sohraby S, Sorscher EJ, Brenner BM, Benos DJ. 1988. Phosphorylation of a single subunit of the epithelial Na channel protein following vasopressin treatment of A6 cells. J. Biol. Chem. 263:13875-79
165. Sasaki S, Fushimi K, Uchida S, Marumo F. 1992. Regulation and localization of two types of water channel in the rat kidney. J. Am. Soc. Nephrol. 3:798 (Abstr.)
166. Satoh T, Cohen HT, Kats AI. 1992. Intracellular signaling in the regulation of renal Na-K-ATPase. I. role of cyclic AMP and phospholipase A2. J. Clin. Invest. 89:1496-1500
167. + channels in the cortical collecting duct by AVP and mineralocorticoids. Kidney Int. 41:255-68
168. + conductance produced in rat CCD by vasopressin. Am. J. Physiol. 259(28):F823-31
169. + secretion in rat CCD. Am. J. Physiol. 258:F199-210
170. Schlondorff D, Levine SD. 1985. Inhibition of vasopressin stimulated water flow in toad bladder by phorbol myristate acetate, dioctanoylglycerol, and RHC-80267. J. Clin. Invest. 76:1071-78
171. Schlondorff D, Satriano JA, Schwartz GJ. 1985. Synthesis of prostaglandin E2 in different segments of isolated collecting tubules from adult and neonatal rabbits. Am. J. Physiol. 248:F134-44
172. Schuster VL. 1985. Mechanism of bradykinin, ADH, and cAMP interaction in rabbit cortical collecting duct. Am. J. Physiol. 249:F645-53
173. Schuster VL. 1993. Function and regulation of collecting duct intercalated cells. Annu. Rev. Physiol. 55:267-88
174. Scott JD. 1991. Cyclic nucleotide-dependent protein kinases. Pharmacol. Ther. 50:123-45
175. Scott JD, Stofko RE, McDonalds JR, Comer JD, Vitalis EA, Mangili JA. 1990. Type II regulatory subunit dimerization determines the subcellular localization of the cAMP-dependent protein kinase. J. Biol. Chem. 265:21561-66
176. Senkfor SI, Johnson GL, Berl T. 1993. Molecular map of G protein a chains in microdissected rat nephron segments. J. Clin. Invest. 92:786-90
177. Shacter E, Stadtman ER, Jurgensen SR, Chock PB. 1988. Role of cAMP in cyclic cascade regulation. See Ref. 16, pp. 3-19
178. Shariff A, Luna E. 1992. Diacyl-glycerol-stimulated formation of actin nucleation sites at plasma membranes. Science 256(256):245-47
179. Shayman JA, Morrissey JJ, Morrison AR. 1987. Islet activating protein inhibits kinin-stimulated inositol phosphate production, calcium mobilization, and prostaglandin E2 synthesis in renal papillary collecting tubule cells independent of cyclic AMP. J. Biol. Chem. 262:17083-87
180. Shimizu T, Yoshitomi K, Nakamura M, Imai M. 1988. Site and mechanism of action of trichlormethiazide in rabbit distal nephron segments perfused in vitro. J. Clin. Invest. 82:721-30
181. Skorecki KL, Verkman AS, Ausiello DA. 1987. Cross talk between stimulatory and inhibitory guanosine 5′-triphosphate binding proteins:role in activation and desensitization of the adenylate cyclase response to vasopressin. Biochemistry. 26:639-45
182. 2. J. Biol. Chem. 262(9):4200-7
183. Smrck AV, Hepler JR, Brown KO, Sternweis PC. 1991. Regulation of polyphosphoinositide-specific phospholipase C activity by purified Gq. Science 804:804-7
184. 2+ exchange as a major calcium influx pathway in kidney cells. J. Biol. Chem. 260:14998-5007
185. Snyder HM, Fredin DM, Breyer MD. 1991. Muscarinic receptor activation inhibits AVP-induced water flow in rabbit cortical collecting ducts. Am. J. Physiol. 260:F283-36
186. Snyder HM, Noland TD, Breyer MD. 1992. cAMP-dependent kinase mediates hydroosmotic effect of vasopressin in collecting duct. Am. J. Physiol. 263:C147-53
187. Sonnenburg WK, Mullaney PJ, Beavo JA. 1991. Molecular cloning of a cyclic GMP-stimulated cyclic nucleotide phosphodiesterase cDNA:identification and distribution of isozyme variants. J. Biol. Chem. 266(26):17655-61
188. Sonnenburg WK, Smith WL. 1988. Regulation of cyclic AMP metabolism in rabbit cortical collecting tubule cells by prostaglandins. J. Biol. Chem. 263:6155-60
189. Sonnenburg WK, Zhu J, Smith WL. 1990. A prostglandin E receptor coupled to a pertussis toxin-sensitive guanine nucleotide regulatory protein in rabbit cortical collecting tubule cells J. Biol. Chem. 265:8479-83
190. Stanton BA. 1991. Molecular mechanisms of ANP inhibition of renal sodium transport. Can. J. Physiol. Pharmacol. 69:1546-52
191. Star RA, Nonoguchi H, Balaban RB, Knepper MA. 1988. Calcium and cyclic adenosine monophosphate as second messengers for vasopressin in the rat inner medullary collecting duct. J. Clin. Invest. 81:1879-88
192. 2+] in renal tubular epithelial cells:evidence for oxytocin receptors on LLC-PK1 cells. Mol. Pharmacol. 33:218-24
193. Stoos BA, Carretero OA, Farhy RD, Scicili G, Garvin JL. 1992. Endothelium-derived relaxing factor inhibits transport and increases cGMP content in cultured mouse cortical collecting duct cells. J. Clin. Invest. 89:761-65
194. Stow JL, Sabolic I, Brown D. 1991. Heterogeneous localization of G protein α-subunits in rat kidney. Am. J. Physiol. 1991:F831-40
195. Strange K, Spring KR. 1987. Cell membrane water permeability of rabbit cortical collecting duct. J. Membr. Biol. 96:27-43
196. +-ATPase. Biochem. Biophys. Acta 988:185-220
197. Takeda S, Lin C-T, Morgano PG, McIntyre SJ, Dousa TP. 1991. High activity of low-Michaelis-Menten constant 3′,5′-cyclic adenosine monophosphate-phosphodiesterase isozymes in renal inner medula of mice with hereditary nephrogenic diabetes insipidus. Endocrinology. 129:287-94
198. Taussig R, Qaurmby LM, Oilman AG. 1993. Regulation of purified type I and type II adenylylcyclases by G protein bg subunits. J. Biol. Chem. 268:9-12
199. Taylor A, Mamelak M, Reaven E, Maffly R. 1973. Vasopressin:possible role of microtubules and microfilaments in its action. Science 181:347-50
200. Taylor SJ, Chae HZ, Rhee SO, Exton JH. 1991. Activation of the β1 isozyme of phospholipase C by a subunits of the Gq class of G proteins. Nature 350:516-18200.
201. Teitelbaum I. 1990. The epidermal growth factor receptor is coupled to a phospholipase A2-specific, pertussis toxin inhibitable guanine nucleotide-binding regulatory protein in cultured rat inner medullary collecting tubule cells. J. Biol. Chem. 265:4218-22
202. Tereda Y, Knepper MA. 1990. Thiazide sensitive NaCl absorption in rat cortical collecting duct. Am. J. Physiol. 259:F519-28
203. Tereda Y, Moriyama T, Martin BM, Knepper MA, Garcia PA. 1991. RT-PCR microlocalization of mRNA for guanylyl cyclase-coupled ANF receptor in rat kidney. Am. J. Physiol. 261:F1080-87
204. Tereda Y, Tomita K, Nonoguchi H, Marumo F. 1992. Polymerase chain reaction localization of constitutive nitric oxide synthase and soluble guanylate cyclasc messenger RNAs in micro dissected rat nephron segments. J. Clin. Invest. 90:659-65
205. Tetsuka T, Kusano E, Takeda S, Homma S, Ando Y, Asano Y. 1992. Phorbol myristate acetate (PMA) activates rolipram sensitive cyclic AMP phosphodiesterasc (PDIE) in medullary collecting tubules (MCT) of the rat kidney. J. Am. Soc. Nephrol. 3:510
206. Torikai S, Kurokawa K. 1983. Effect of PGE2 on vasopressin-dependent cell cAMP in isolated single nephron segments. Am. J. Physiol. 249:F58-F66
207. Ujiie K, Drewett JG, Yuen ST, Star RA. 1993. Differential expression of mRNA for guanylyl cyclase-linked endothelium derived relaxing (actor receptor subunits in rat kidney. J. Clin. Invest. 91:730-34
208. Vehaskari VM, Hering-Smith KS, Moskowitz DW, Weiner ID, Hamm LL. 1989. Effect of epidermal growth factor on sodium transport in the cortical collecting tubule. Am. J. Physiol. 256:F803-9
209. Vehaskari VM, Herndon J, Hamm LL, 1991. Mechanism of sodium transport inhibition by epidermal growth factor in cortical collecting ducts. Am. J. Physiol. 261:F896-903
210. Verkman AS, Lencer WI, Brown D, Ausiello DA. 1988. Endosomes from kidney collecting tubule cells contain the vasopressin-sensitive water channel. Nature 333:268-69
211. Wade JB, Kachadorian WA. 1988. Cytochalasin B inhibition of toad bladder apical membrane responses to ADH. Am. J. Physiol. 255:C526
212. Walker LA, Whorton AR, Smigel M, France R, Frölich JC. 1978. Antidiuretic hormone increases renal prostaglandin synthesis in vivo. Am. J. Physiol. 234:F180-85
213. + channel of the rat cortical collecting duct. J. Gen. Physiol. 98:35-61
214. + channel by protein kinases A and C. Proc. Natl. Acad. Sci. USA 88:9722-25
215. Wang W, Sackin H, Giebisch G. 1992. Renal potassium channels and their regulation. Annu. Rev. Physiol. 54:81-96
216. + -ATPase. Am. J. Physiol. 264:F670-77
217. Wilke TM, Scherle PA, Strathmann MP, Slepak VZ, Simon MI. 1991. Characterization of G-protein α sub-units in the Gq class:Expression in murine tissues and in stromal and hematopoietic cell lines. Proc. Natl. Acad. Sci. USA 88:10049-53
218. Wong S-K-F, Garbers DL. 1992. Receptor guanylyl cyclases. J. Clin. Invest. 90:299-305
219. 2+ in HL-60 granulocytes. J. Biol. Chem. 267(36):25966-75
220. Yagil Y. 1992. Differential effect of basolateral and apical adenosine on AVP-stimulated cAMP formation in primary culture of IMCD. Am. J. Physiol. 263:F268-76
221. Yanese M, Handler JS. 1986. Activators of protein kinase C inhibit sodium transport in A6 epithelia. Am. J. Physiol. 250:C517-22
222. 2+ inhibitable adenylyl cyclase from NCB-20 cells. Proc. Natl. Acad. Sci. USA 89:6716-20
223. +-ATPase in intact renal tubular epithelial cells. Am. J. Physiol. 257:C1101-07