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Current Opinion in Cell Biology
Volumn 6, Issue 3, 1994, Pages 373-379
Telomere maintenance and gene repression: a common end?
Author keywords

[No Author keywords available]
Indexed keywords

DNA; TRANSCRIPTION FACTOR;
EID: 0028206318     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0955-0674(94)90029-9     Document Type: Article
Times cited : (43)
References (40)
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    • of outstanding interest, A comprehensive review focusing on transcriptional silencing at the mating-type locus, including the genes and sequences required, evidence for a role of chromatin structure in establishing the silenced state, heritable aspects of the silencing mechanism, and the potential link between DNA replication and silencing. Parallels are drawn between mating type and telomeric silencing in yeast and silencing in Bacillus subtilis, Drosophila and mammals.
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    • of special interest, A detailed analysis, including extensive sequence comparison, of the structure of subtelomeric repeats in yeast, and speculation on the evolution and functional role of these repeats.
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    • of outstanding interest, The authors show that when normal telomere replication is defective, the amplification and distribution of Y′ subtelomeric elements play a role in maintaining telomere function and cell viability.
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    • of outstanding interest, The results show that the promoter of a gene is a key determinant in controlling silencing, and strongly implicate SIR3 as the key factor in the establishment and extension of silent chromatin domains. The repressed telomeric domain is shown to propagate continuously along the DNA.
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    • Loss of a Yeast Telomere: Arrest, Recovery, and Chromosome Loss
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    • of special interest, The first cloning and sequencing of a true Drosophila telomere reveals a total lack of terminal repeats. Rather, a retrotransposon called TART (telomere-associated retrotransposon) and the previously described HeT-A elements are found in multiple repeats at Drosophila telomeres, presumably transposed there from other sites in the genome.
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    • 1–3 Repeats
    • of outstanding interest, The authors show that de novo telomere formation in yeast occurs in the absence of recombination, and in every case examined consists of the initial addition of one of two related motifs. They suggested that the addition of these motifs may reflect the RNA template of a yeast telomerase.
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    • Distortion of the DNA Double Helix by RAP1 at Silencers and Multiple Telomeric Binding Sites
    • of special interest, In yeast telomeric repeat sequence, RAP1 binds once per 18bp in vitro. RAP1 is also shown to distort DNA in two ways: by creating a permanganate-sensitive site whithin its consensus sequence, and by bending the double helix.
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    • C-Terminal Truncation of RAP1 Results in the Deregulation of Telomere Size, Stability, and Function in Saccharomyces cerevisiae
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    • Modifiers of Position Effect are Shared Between Telomeric and Silent Mating Type Loci in S. cerevisiae
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    • Targeting of SIR1 Protein Establishes Transcriptional Silencing at HM Loci and Telomeres in Yeast
    • of outstanding interest, The authors show that targeting the SIR1 protein to telomeres greatly improves telomeric silencing, rendering it more similar to silencing at the mating-type loci. At the HMR locus, a silencer lacking the ARS consensus functions fully if SIR1p is targeted there, suggesting that the role of ORC in the establishment of silencing is to target SIR1p, and not to initiate DNA replication.
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    • Yeast Origin Recognition Complex is Involved in DNA Replication and Transcriptional Silencing
    • of outstanding interest, Reports the isolation of ORC2, a component of the yeast origin recognition complex, in a screen to identify factors interacting with the ARS consensus sequence at the silent mating type locus HMRE. This demonstrates the important genetic link between components involved in silencing and DNA replication.
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    • Origin Recognition Complex (ORC) in Transcriptional Silencing and DNA Replication in S. cerevisiae
    • of outstanding interest, Reports the cloning and characterization of ORC2 in a screen for mutants defective in silencing at the mating type locus HMR, providing an important and direct genetic link between DNA replication and silencing.
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    • Yeast Origin Recognition Complex Functions in Transcriptional Silencing and DNA Replication in S. cerevisiae
    • of special interest, Evidence is presented that ORC2, a component of the ARS consensus binding complex, is able to bind the ARS elements within the mating type silencers in vitro. Together with the results in [27 of outstanding interest], this suggests a mechanistic link between DNA replication and silencing.
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    • Telomere-Proximal DNA in Saccharomyces cerevisiae is Refractory to Methyltransferase Activity in Vivo
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    • Transcriptional Silencing in Yeast is Associated with Reduced Nucleosome Acetylation
    • of outstanding interest, The data presented are the first to show a direct correlation between core-histone deacetylation and transcriptional silencing at the mating-type loci and telomeres. The results presented support the model that a specific SIR-dependent chromatin structure contributes to silencing at these loci, implicating SIR2p directly in deacetylation.
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    • SIR3 and SIR4 Proteins Are Required for the Positioning and Integrity of Yeast Telomeres
    • of outstanding interest, Evidence is presented showing that SIR3 and SIR4 are required for the integrity of telomeres and the perinuclear localization of telomeres, as monitored by RAP1 immunofluorescence. SIR3 and SIR4 are localized to foci at the periphery of the yeast nucleus, like RAP1.
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    • Yeast Telomere Repeat Sequence TRS. Improves Circular Plasmid Segregation, and TRS Plasmid Segregation Involves the RAP1 Gene Product
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    • Telomere-Mediated Plasmid Segregation in Saccharomyces cerevisiae Involves Gene Products Required for Transcriptional Repression at Silencers and Telomeres
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    • A RAP-1-Interacting Protein Involved in Transcriptional Silencing and Telomere Length Regulation
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    • RAP1 and Telomere Structure Regulate Telomere Position Effects in Saccharomyces cerevisiae
    • 1–3 repeats is suggested by the finding that longer tracts are able to increase the frequency of transcriptional repression at telomeres.
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    • The RAP1 Protein Activates and Silences Transcription of Mating Type Genes in Yeast
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    • Cloning and Characterization of Four SIR Genes of Saccharomyces cerevisiae
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    • The Enhancement of Telomere-Plasmid Segregation by X-Telomere Associated Sequences in Saccharomyces cerevisiae Involves SIR2, SIR3, SIR4, and ABF1
    • of special interest, The evidence provided suggests an active role for STRs in modulating telomere function in the enhancement of plasmid stability. A function is suggested for the ABF1 site and the ARS consensus sequence found within these sequences.
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    • Enomoto1    Longtime2    Berman3

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.