Structure-Function Analysis of Signal and Growth Inhibition by Carboxyamido-triazole, CAI

Cancer Research

Volumn 54, Issue 4, 1994, Pages 935-942

  Day, Alan ^c   Freer, Richard ^c   Holmes, Katherine A ^a   Liotta, Lance A ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^c VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINO 1 [3,5 DICHLORO 4 (4 CHLOROBENZOYL)BENZYL] 1H 1,2,3 TRIAZOLE 4 CARBOXAMIDE; ANTINEOPLASTIC AGENT; ARACHIDONIC ACID; CALCIUM 45; CALCIUM ION; MUSCARINIC M5 RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CANCER GROWTH; CANCER INHIBITION; CANCER INVASION; CELL PROLIFERATION; CHO CELL; COLONY FORMATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; LUNG METASTASIS; MELANOMA CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

AMINOIMIDAZOLE CARBOXAMIDE; ANIMALS; ANTINEOPLASTIC AGENTS; ARACHIDONIC ACID; CALCIUM; CELL DIVISION; CHO CELLS; CRICETINAE; CRICETULUS; HUMANS; LUNG NEOPLASMS; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES; TUMOR CELLS, CULTURED;

EID: 0028205812     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Aaronson, S. Growth factors and cancer. Science (Washington DC), 254: 1146-1153, 1991.
2. Rink, T.J. Receptor-mediated calcium entry. FEBS Lett., 268: 381-385, 1990.
3. Simon, M.I., Strathmann, M.P., and Gautam, N. Diversity of G proteins in signal transduction. Science (Washington DC), 252: 802-808, 1991.
4. Gusovsky, F., Lueders, J.E., Kohn, E.C., and Felder, C.C. Muscarinic receptor-mediated tyrosine phosphorylation of phospholipase C-7: alternative mechanism for cholinergic receptor-induced phosphoinositide breakdown. J. Biol. Chem., 268: 7768-7772, 1993.
5. Meldolesi, J., Clementi E., Fusolato, C., Zacchetti, D., and Pozzan, T. Ca2+ influx following receptor activation. Trends Pharmacol. Sci., 12: 289-292, 1991.
6. Berridge, M.J., and Irvine, J.L. Inositol phosphates and cell signalling. Nature (Lond.), 341: 197-205, 1989.
7. Clark, J.D., Lin, L.L., Kriz, R.W., Ramesha, C.S., Sultzman, L.A., Lin, A.Y., Milona, M., and Knopf, J.L. A novel arachidonic acid-selective cytosolic PLA2 contains a Ca2+-dependent translocation domain with homology to PKC and GAP. Cell, 65: 1043-1051, 1991.
8. Felder, C.C., Ma, A.L., Liotta, L.A., and Kohn, E.C. The antiproliferative and antimetastatic compound L651582 inhibits muscarinic acetylcholine receptor-stimulated calcium influx and arachidonic acid release. J. Pharmacol. Exp. Ther., 257: 967-971, 1991.
9. Hupe, D.J., Boltz, R., Cohen, C.J., Felix, J., Ham, E., Miller, D., Soderman, D., and Van Skiver, D. The inhibition of receptor-mediated and voltage-dependent calcium entry by the antiproliferative L-651, 582. J. Biol. Chem., 266: 10136-10142, 1991.
10. Kohn, E.C., and Liotta, L.A. L651582: a novel antiproliferative and antimetastasis agent. J. Natl. Cancer Inst., 82: 54-60, 1990.
11. Kohn, E.C., Sandeen, M.A., and Liotta, L.A. In vivo efficacy of a novel inhibitor of selected signal transduction pathways including calcium, arachidonate, and inositol phosphates. Cancer Res., 52: 3208-3212, 1992.
12. Felder, C.C., Dieter, P., Kinsella, J., Tamura, K., Kanterman, T.Y., and Axelrod, J. A transfected m5 muscarinic acetylcholine receptor stimulates phospholipase A2 by inducing both calcium influx and activation of protein kinase C.J. Pharmacol. Exp. Ther., 255: 1140-1147, 1990.
13. Kim, H.K., Kim, J.W., Zilberstein, A., et al. PDGF stimulation of inositol phospholipid hydrolysis requires PLC-7I phosphorylation on tyrosine residues 783 and 1254. Cell, 65: 435-41, 1991.
14. Nishibe, S., Wahl, M.I., Hernandez-Sotomayor, S.M.T., Tonks, N.K., Rhee, S.G., and Carpenter, G. Increase of the catalytic activity of phospholipase C-7I by tyrosine phosphorylation. Science (Washington DC), 250: 1253-1256, 1990.
15. Margolis, B., Rhee, S.G., Felder, S., Mervic, M., Lyall, R., Levitzki, A., Ullrich, A., Zilberstein, A., and Schlessinger, J. EGF induces tyrosine phosphorylation of phospholipase C-II: a potential mechanism for EGF receptor signaling. Cell, 57: 1101-1107, 1989.
16. Bianchini, L., Todderud, G., and Grinstein, S. Cytosolic (Ca2+) homeostasis and tyrosine phosphorylation of phospholipase C-y2 in HL60 granulocytes. J. Biol. Chem., 268: 3357-3363, 1993.
17. Tanaguchi, T., Kitagawea, H., Yasue, S. et al. Protein-tyrosine kinase p. 2SYK is activated by thrombin and is negatively regulated through Ca2+ regulation in platelets. J. Biol. Chem., 268: 2277-2279, 1993.
18. Julius, D., Livelli, T.J., Jessell, T.M., and Axel, R. Ectopic expression of the serotonin lc receptor and triggering of malignant transformation. Science (Washington DC), 244: 1057-1062, 1989.
19. Allen, L.E., Lefkowitz, R.J., Caron, M.G., and Cotecchia, S. G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the a1B-adrenergic receptor enhances mitogenesis and tumorigenicity. Proc. Natl. Acad. Sci. USA, 88: 11354-11358, 1991.
20. Gutkind, J.S., Novotny, E.A., Brann, M.R., and Robbins, K.C. Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes. Proc. Natl. Acad. Sci. USA, 88: 4703-4707, 1991.
21. Godefroi, E., Heeres, J., van Custen, J., and Jannsen, P.A. The preparation and antimycotic properties of derivatives of 1-phenyethylimidazole. J. Med. Chem., 784-791, 1969.
22. Chabala, J.C., Waits, V.B., Pathcett, A.A., Payne, L., Peterson, L.H., Reamer, R.A., Hoogsteen, K., Wyvratt, M., Hanson, W.L., and Fisher, M.H. 1-(substituted) benzyl-5-aminoimidazole-4-carboxamides are potent orally active inhibitors of Trypanosoma cruzi in mice. Experientia (Basel), 47: 51-53, 1991.
23. Bochis, R.J., Chabala, J.C., and Fisher, M.H. 5-amino or substituted amino, 1, 2, 3-triazoles. U.S. Patent 4, 590, 201, May 20, 1986.
24. Pozzati, R.P., Muschel, R., Williams, J., Padmanabhan, R., Howard, B., Liotta, L., and Khoury, G. Primary rat embryo cells transformed with one or two oncogenes show different metastatic potentials. Science (Washington DC), 232: 223-227, 1986.
25. Felder, C.C., Poulter, M.O., and Wess, J. Muscarinic receptor-operated Ca2+ influx in transfected fibroblast cells is independent of inositol phosphates and release of intracellular Ca2+. Proc. Natl. Acad. Sci. USA, 89: 509-513, 1992.
26. Conklin, B.R., Brann, M.R., Buckley, N.J., Ma, A.L., Bonner, T.I., and Axelrod, J. Stimulation of arachidonic acid release and inhibition of mitogenesis by cloned genes for muscarinic receptor subtypes stably expressed in A9 L cells. Proc. Natl. Acad. Sci. USA, 85: 8698-8702, 1988.
27. Marnett, L.J. Aspirin and the potential role of prostaglandins in colon cancer. Cancer Res., 52: 5575-5589, 1992.
28. Liotta, L.A. Tumor invasion: role of the extracellular matrix. Cancer Res., 46: 1-7, 1986.
29. Merritt, J.E., Armstrong, W.P., Benham, C.D., Hallam, T.J., Jacob, R., Jaxa-Chamiec, A., Leigh, B.K., McCarthy, S.A., Moores, K.E., and Rink, T.J. SK&F 96365, a novel inhibitor of receptor-mediated calcium entry. Biochem. J., 277: 515-522, 1990.
30. Short, A.D., Bian, J., Bhosh, T.K., Waldron, R.T., Rybak, S.L., and Gill, D.L. Intracellular Ca2+ pool content is linked to control of cell growth. Proc. Natl. Acad. Sci. USA, 90: 4986-4990, 1993.
31. Young, M.R., Young, M.E., and Wepsic, H.T. Effect of prostaglandin E2-producing nonmetastatic Lewis lung carcinoma cells on the migration of prostaglandin E2-responsive metastatic Lewis lung carcinoma cells. Cancer Res., 47: 3679-3683, 1987.
32. Fulton, A.M., Zhang, Sz., and Chong, Y.C. Role of the prostaglandin E2 receptor in mammary tumor metastasis. Cancer Res., 51: 2047-2050, 1991.
33. Honn, K.V., Bockman, R.S., and Marnett, L.J. Prostaglandins and cancer: a review of tumor initiation through tumor metastasis. Prostaglandin, 21: 833-864, 1981.
34. Levine, L., and Hassid, A. Epidermal growth factor stimulates prostaglandin biosynthesis by canine kidney (MDCK) cells. Biochem. Biophys. Res. Commun., 79: 477-484, 1977.
35. Bennett, A., Houghton, J., Leaper, D.J., and Stamford, I.F. Cancer growth, response to treatment and survival time in mice: beneficial effect of the prostaglandin synthesis inhibitor flurbiprofen. Br. J. Pharmacol., 63: 356-375, 1978.
36. Lynch, N.R., and Salomon, J.C. Tumor growth inhibition and potentiation of immunotherapy by indomethacin in mice. J. Natl. Cancer Inst., 62: 117-121, 1979.
37. Pollard, M., and Luckert, P.H. Effect of indomethacin on intestinal tumors induced in rats by the acetate derivative of dimethylnitrosamine. Science (Washington DC), 214: 558-559, 1981.
38. Rigau, J., Pique, J.M., Rubio, E., Planas, R., Tarrech, J.M., and Bordas, J.M. Effects of long-term sulindac therapy on colonic polyposis. Ann. Int. Med., 115: 952-954, 1991.
39. Waddell, W.R., Ganser, G.F., Cerise, E.J., and Loughry, R.W. Sulindac for polyposis of the colon. Am. J. Surg., 757: 175-179, 1989.
40. Thun, M.J., Namboodiri, M.M., and Heath, C.W. Aspirin use and reduced risk of fatal colon cancer. N. Engl. Med., 325: 1593-1596, 1991.