Impairment in mitochondrial cytochrome oxidase gene expression in Alzheimer disease

Molecular Brain Research

Volumn 24, Issue 1-4, 1994, Pages 336-340

  Chandrasekaran, Krish ^a   Giordano, Tony ^b   Brady, Daniel R ^a   Stoll, James ^a   Martin, Lee J ^c   Rapoport, Stanley I ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b ABBOTT LABORATORIES   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; Human brain; Northern blot; Oxidative metabolism; Primary motor cortex; Synaptic loss; Temporal cortex

Indexed keywords

CYTOCHROME C OXIDASE; MESSENGER RNA;

AEROBIC METABOLISM; AGED; ALZHEIMER DISEASE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; MALE; MOTOR CORTEX; NORTHERN BLOTTING; PRIORITY JOURNAL; TEMPORAL CORTEX;

ACTINS; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AUTOPSY; BIOLOGICAL MARKERS; BLOTTING, NORTHERN; BRAIN; COMPARATIVE STUDY; CYTOCHROME-C OXIDASE; FEMALE; GENE EXPRESSION; HUMAN; LACTATE DEHYDROGENASE; MACROMOLECULAR SYSTEMS; MALE; MITOCHONDRIA; REFERENCE VALUES; RNA, MESSENGER; RNA, RIBOSOMAL;

EID: 0028199881     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0169-328X(94)90147-3     Document Type: Article

References (30)

1. Sequence and organization of the human mitochondrial genome
2. Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases?
3. Regional mitochondrial respiratory activity in Huntington's disease brain
4. Structure and function of cytochrome c oxidase
5. Differential expression of cytochrome oxidase (COX) genes in different regions of monkey brain
6. Distribution ofcytochrome oxidase (COX) activity and mRNA in monkey and human brain
7. Impairments in mitochondrial gene expression in vulnerable brain regions in Alzheimer's disease
8. Localization of cytochrome oxidase (COX) activity and COX mRNA in the perirhinal and superior temporal sulci of the monkey brain
9. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
10. Positron emission tomography in Alzheimer's disease
11. ATP and brain function
12. Markedly different ATP requirements for rRNA synthesis and mtDNA light strand transcriptionversus mRNA synthesis in isolated human mitochondria
13. Neuropsychological and cerebral metabolic function in early vs late onset dementia of the Alzheimer type
14. Mechanisms by which mitochondria transport calcium
15. Mitochondria, molecular chaperone proteins and the in vivo assembly of microtubules
16. Neocortical metabolic abnormalities precede non-memory cognitive defects in early Alzheimer's-type dementia
17. Diagnosis of Alzheimer's disease
18. Brain cytochrome oxidase in Alzheimer's disease
19. Mitochondrial DNA mutation as an important contributor to ageing and degenerative diseases
20. The pattern of transcription of the human mitochondrial rRNA genes reveal two overlapping transcription units
21. Calcium-mediated mechanisms in chemically induced cell death
22. Glutamate becomes neurotoxic via the N-methyl-d-aspartate receptor when intracellular energy levels are reduced
23. Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease
24. Cytochrome oxidase deficiency in Alzheimer's disease
25. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
26. The cDNA and protein sequences of human lactate dehydrogenase B
27. 14C]-deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in conscious and anaesthetized albino rat
28. Movement of organelles along filaments dissociated from the axoplasm of the squid giant axon
29. Cytochrome oxidase: an endogenous metabolic marker for neuronal activity