The JNM1 gene in the yeast Saccharomyces cerevisiae is required for nuclear migration and spindle orientation during the mitotic cell cycle

Journal of Cell Biology

Volumn 125, Issue 1, 1994, Pages 143-158

  McMillan, John N ^a   Tatchell, Kelly ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENOMYL; CELL PROTEIN; DNA; DYNEIN ADENOSINE TRIPHOSPHATASE;

ARTICLE; CELL GROWTH; CELL MIGRATION; CELL NUCLEUS; CELL STRUCTURE; MITOSIS; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SPINDLE CELL; TEMPERATURE SENSITIVE MUTANT;

HYLOBATIDAE; SACCHAROMYCES CEREVISIAE;

EID: 0028199609     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.125.1.143     Document Type: Article

References (52)

1. Becker, D. M., and L. Guarente. 1991. High-efficiency transformation of yeast by electroporation. Methods Enzymol. 194:182-187.
2. Berlin, V., C. A. Styles, and G. R. Fink. 1990. BIK1, a protein required for microtubule function during mating and mitosis in Saccharomyces cerevisiae, colocalizes with tubulin. J. Cell Biol. 111:2573-2586.
3. Cannon, J. F., and K. T. Tatchell. 1987. Characterization of Saccharomyces cerevisiae genes encoding subunits of cyclic AMP-dependent protein kinase. Mol. Cell Biol. 7:2653-2663.
4. Costigan, C., S. Gehrung, and M. Snyder. 1992. A synthetic lethal screen identifies SLK1, a novel protein kinase homolog implicated in yeast cell morphologies and cell growth. Mol. Cell Biol. 12:1162-1178.
5. Elledge, S. J., and R. W. Davis. 1988. A family of versatile centromeric vectors designed for use in the sectoring-shuffle mutagenesis assay in Saccharomyces cerevisiae. Gene (Amst.). 70:303-312.
6. Eshel, D., L. A. Urrestarazu, S. Vissers, J.-C. Jauniaux, J. C. van Vliet-Reedijk, R. J. Planta, and I. R. Gibbons. 1993. Cytoplasmic dynein is required for normal nuclear segregation in yeast. Proc. Natl. Acad. Sci. USA. 90:11172-11176.
7. Gerring, S. L., F. Spencer, and P. Hieter. 1990. The CHL1(CTF1) gene product of Saccharomyces cerevisiae is important for chromosome transmission and normal cell cycle progression in G2/M. EMBO (Eur. Mol. Biol. Organ.) J. 9:4347-4358.
8. Gibbons, I. R., B. H. Gibbons, G. Mocz, and D. J. Asai. 1991. Multiple nucleotide-binding sites in the sequence of dynein beta heavy chain Nature (Lond.). 352:640-643.
9. Gietz, D., A. St. Jean, R. A. Woods, and R. H. Schiestl. 1992. Improved method for high efficiency transformation of intact yeast cells. Nucleic Acids Res. 20:1425.
10. Goldring, E. S., L. I. Grossman, D. Krupnick, D. R. Cryer, and J. Marmur. 1970. The petite mutation in yeast: loss of mitochondrial deoxyribonucleic acid during induction of petites with ethidium bromide. J. Mol. Biol. 52:323-335.
11. Hieter, P., C. Mann, M. Snyder, and R. W. Davis. 1985. Mitotic stability of yeast chromosomes: a colony color assay that measures nondisjunction and chromosome loss. Cell. 40:381-392.
12. Hoyt, M. A., L. Totis, and B. T. Roberts. 1991. S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function. Cell. 66:507-517.
13. Hoyt, M. A., L. He, K. K. Loo, and W. S. Saunders. 1992. Two Saccharomyces cerevisiae kinesin-related gene products required for mitotic spindle assembly. J. Cell Biol. 118:109-120.
14. Huffaker, T. C., J. H. Thomas, and D. Botstein. 1988. Diverse effects of β-tubulin mutations on microtubule formation and function. J. Cell Biol. 106:1997-2010.
15. Hyman, A. A. 1989. Centrosome movement in the early divisions of Caenorhabditis elegans: a cortical site determining centrosome position. J. Cell Biol. 105:2123-2135.
16. Ito, H., Y. Fukuda, D. Murata, andA. Kimura. 1983. Transformation of intact yeast cells treated with alkali cations. J. Bacteriol. 153:163-168.
17. Jacobs, C. W., A. E. M. Adams, P. J. Szaniszlo, and J. R. Pringle. 1988. Functions of microtubules in the Saccharomyces cerevisiae cell cycle. J. Cell Biol. 107:1409-1426.
18. + gene encodes a 100-kDa essential protein implicated in mitotic control. Mol. Cell Biol. 11:5839-5847.
19. Kormanec, J., I. Schaaff-Gerstenschlager, F. K. Zimmermann, D. Perecko, and H. Kuntzel. 1991. Nuclear migration in Saccharomyces cerevisiae is controlled by the highly repetitive 313 kDa NUM1 protein. Mol. Gen. Genet. 230:277-287.
20. Lea, D. E., and C. A. Coulson. 1949. The distribution of the numbers of mutants in bacterial populations. J. Genet. 49:264-285.
21. Li, R., and A. W. Murray. 1991. Feedback control of mitosis in budding yeast. Cell. 66:519-531.
22. Li, Y.-Y., E. Yen, T. Hays, and K. Bloom. 1993. Disruption of mitotic spindle orientation in a yeast dynein mutant. Proc. Natl. Acad. Sci. USA. 90: 10096-10100.
23. Lillie, S. H., and S. S. Brown. 1992. Suppression of a myosin defect by a kinesin-related gene. Nature (Lond.). 356:358-361.
24. Lupas, A., M. Van Dyke, and J. Stock. 1991. Predicting coiled coils from protein sequences. Science (Wash. DC). 252:1162-1164.
25. Lutz, D. A., Y. Hamaguchi, and S. Inoue. 1988. Micromanipulation studies of the asymmetric positioning of the maturation spindle in Charptopterus sp. oocytes: anchorage of the spindle to the cortex and migration of a displaced spindle. Cell Motil. Cytoskeleton. 11:83-96.
26. McConnell, S. J., and M. P. Yaffe. 1992. Nuclear and mitochondrial inheritance in yeast depends on novel cytoplasmic structures defined by the MDMI protein. J. Cell Biol. 118:385-395.
27. Meluh, P. B., and M. D. Rose. 1990. KAR3, a kinesin-related gene required for yeast nuclear fusion. Cell. 60:1029-1041.
28. Myers, A. M., A. Tzagoloff, D. M. Kinney, and C. J. Lusty. 1986. Yeast shuttle and integrative vectors with multiple cloning sites suitable for construction of lacZ fusions. Gene (Amst.). 45:299-310.
29. Ogawa, K. 1991. Four ATP-binding sites in the midregion of the beta heavy chain of dynein. Nature (Lond.). 352:643-645.
30. Palmer, R. E., D. S. Sullivan, T. Huffaker, and D. Koshland. 1992. Role of astral microtubules and actin in spindle orientation and migration in the budding yeast, Saccharomyces cerevisiae. J. Cell Biol. 119:583-593.
31. Paschal, B. M., and R. B. Vallee 1987. Retrograde transport by the microtubule-associated protein MAP 1C. Nature (Lond.). 330:181-183.
32. Paschal, B. M., A. Mikami, K. K. Pfister, and R. B. Vallee. 1992. Homology of the 74-kD cytoplasmic dynein subunit with a flagellar dynein polypeptide suggests an intracellular targeting function. J. Cell Biol. 118:1133-1143.
33. Perkins, D.D. 1949. Biochemical mutants of the smut fungus Ustilago maydis. Genetics. 34:607-629.
34. Pfarr, C. M., M. Coue, P. M. Grissom, T. S. Hays, M. E. Porter, and J. R. McIntosh. 1990. Cytoplasmic dynein is localized to kinetochores during mitosis. Nature (Lond.). 345:263-265.
35. Pringle, J. R., and L. H. Hartwell. 1981. The Saccharomyces cerevisiae cell cycle. In The Molecular Biology of the Yeast Saccharomyces cerevisiae. Vol. 1. Strathern, J. N., E. W. Jones, and J. R. Broach, editors. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY. 97-142.
36. Pringle, J. R., A. E. M. Adams, D. G. Drubin, and B. K. Haarer. 1991. Immunofluorescence methods for yeast. Methods Enzymol. 194:565-608.
37. Roof, D. M., P. B. Meluh, and M. D. Rose. 1992. Kinesin-related proteins required for assembly of the mitotic spindle. J. Cell Biol. 118:95-108.
38. Rose, M. D., F. Winston, and P. Hieter. 1990. Methods in Yeast Genetics: A Laboratory Course Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. 198 pp.
39. Rothstein, R. J. 1983. One-step gene disruption in yeast. Methods Enzymol. 101:202-210.
40. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. 545 pp.
41. Schatz, P. J., F. Solomon, and D. Bostein. 1988. Isolation and characterization of conditional-lethal mutations in the TUB1 α-tubulin gene of the yeast Saccharomyces cerevisiae. Genetics. 120:681-695.
42. Schliwa, M., T. Shimizu, R. D. Vale, and U. Euteneuer. 1991. Nucleotide specificities of anterograde and retrograde organelle transport in Reticulomyxa are indistinguishable. J. Cell Biol. 112:1199-1203.
43. Schnapp, B. J., and T. S. Reese. 1989. Dynein is the motor for retrograde transport of organelles. Proc. Natl. Acad. Sci. USA. 86:1548-1552.
44. Schroer, T. A., E. R. Steuer, and M. P. Sbeetz. 1989. Cytoplasmic dynein is a minus end-directed motor for membranous organelles. Cell. 56:937-946.
45. Stearns, T., M. A. Hoyt, and D. Bostein. 1990. Yerast mutants sensitive to antimicrotubule drugs define three genes that affect microtubule function. Genetics. 124:251-262.
46. Steuer, E. R., L. Wordeman, T. A. Schroer, and M. P. Sheetz. 1990. Localization of cytoplasmic dynein to mitotic spindles and kinetochores. Nature (Lond.). 345:266-268.
47. Sullivan, D. S., and T. C. Huffaker. 1992. Astral microtubules are not required for anaphase B in Saccharomyces cerevisiae. J. Cell Biol. 119:379-388.
48. Sutton, A., D. Immanuel, and K. T. Arndt. 1991. The SIT4 proteinphosphatase functions in late G1 for progression into S phase. Mol. Cell Biol. 11:2133-2148.
49. Ursic, D., and M. R. Culbertson. 1991. The yeast homolog to mouse Tcp-1 affects microtubule-mediated processes. Mol. Cell Biol. 11:2629-2640.
50. Vallen, E. A., T. Y. Scherson, T. Roberts, K. van Zee, and M. D. Rose. 1992. Asymmetric mitotic segregation of the yeast spindle pole body. Cell. 69:505-515.
51. Watts, F. Z., G. Shiels, and E. Orr. 1987. The yeast MYO1 gene encoding a myosin-like protein required for cell division. EMBO (Eur. Mol. Biol. Organ.) J. 6:3499-3505.
52. Wilson, R. B., A. A. Brenner, T. B. White, M. J. Engler, J. P. Gaughran, and K. Tatchell. 1991. The Saccharomyces cerevisiae SRK1 gene, suppressor of bcy1 and ins1, may be involved in protein phosphatase function. Mol. Cell Biol. 11:3369-3373.