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1
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0027309118
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Generation and Regeneration of Cells of the B-Lymphocyte Lineage
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of special interest, A recent comprehensive review concerning early B lymphocyte differentiation.
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(1993)
Curr Opin Immunol
, vol.5
, pp. 207-217
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Rolink1
Melchers2
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3
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0027275497
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The Regulated Expression of B Lineage Associated Genes During B Cell Differentiation in Bone Marrow and Fetal Liver
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(1993)
J Exp Med
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Li1
Hayakawa2
Hardy3
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5
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0025184095
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Lack of N-Regions in Fetal and Neonatal Mouse Ig V-D-J functional Sequences
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(1990)
J Exp Med
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Feeney1
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6
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0023114109
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Phenotype and Proliferation of Early B Lymphocyte Precursor Cells in Mouse Bone Marrow
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(1987)
J Exp Med
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Park1
Osmond2
-
7
-
-
0027450829
-
Distinctive Growth Requirements and Gene Expression Patterns Distinguish Progenitor B Cells from Pre-B Cells
-
of special interest, Examination of the regulated expression of transcription factors and other genes in pro-B cells derived from long-term bone marrow cultures. Selective growth on S17 stromal cells was used to expand cells with multiple characteristics of pro-13 cells in vitro. The configuration of Ig genes and the levels of expression of the RAG-1, RAG-2, TdT, Ets myc, and Pim-1 genes were compared between cultured pro-B cells, mouse lymphoid tissues and cell lines. The roles of c-kit and IL-7 in pro-B and pre-B cell proliferation were examined.
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(1993)
J Exp Med
, vol.177
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Faust1
Saffran2
Toksoz3
Williams4
Witte5
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8
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0026503687
-
Fetal Liver Pro-B and Pre-B Lymphocyte Clones: Expression of Lymphoid-Specific Genes, Surface Markers, Growth Requirements, Colonization of the Bone Marrow, and Generation of B Lymphocytes in Vivo and in Vitro
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(1992)
Mol Cell Biol
, vol.12
, pp. 518-530
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Palacios1
Samardis2
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9
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0023035608
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λ5, a New Light-Chain-Related Locus Selectively Expressed in Pre-B Lymphocytes
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(1986)
Nature
, vol.324
, pp. 579-582
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Sakaguchi1
Melchers2
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10
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0023390930
-
A Second Gene, VpreB in the λ5 Locus of the Mouse, Which Appears To Be Selectively Expressed in Pre-B Lymphocytes
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(1987)
EMBO J
, vol.6
, pp. 2267-2272
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Kudo1
Melchers2
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11
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-
0025968657
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The ω/λ5 Surrogate Ig Light Chain is Expressed on the Surface of Transitional B Lymphocytes in Murine Bone Marrow
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(1991)
J Exp Med
, vol.173
, pp. 111-116
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Cherayil1
Pillai2
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14
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0025156796
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B Lymphocyte Antigen Receptors (mIg) Are NonCovalently Associated With a Disulfide Linked, Inducibly Phosphorylated Glycoprotein Complex
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(1990)
EMBO J
, vol.9
, pp. 441-448
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Campbell1
Cambier2
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18
-
-
0027618650
-
Regulation of the NF-κB/Rel Transcription Factor and IκB Inhibitor System
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of outstanding interest, A comprehensive and updated review of NF-κB and other Rel family members and regulation by the IκB family of inhibitors.
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(1993)
Curr Opin Cell Biol
, vol.5
, pp. 477-487
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-
Liou1
Baltimore2
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20
-
-
0027262608
-
Oct-2, Although Not Required For Early B-Cell Development, is Critical for Later B-Cell Maturation and for Postnatal Survival
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− mice relative to normal littermates. Homozygous mutant mice died shortly after birth for unknown reasons.
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(1993)
Genes Dev
, vol.7
, pp. 570-582
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-
Corcoran1
Karvelas2
Nossai3
Ye4
Jacks5
Baltimore6
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21
-
-
0027171744
-
Targeted Disruption of the Oct-2 Locus in a B Cell Provides Genetic Evidence for Two Distinct Cell Type-Specific Pathways of Octamer Element-Mediated Gene Activation
-
+ lymphoma, had only minor effects on the expression of endogenous gene expression, but expression from a reporter gene containing multiple octamer binding sites was reduced in transfection assays. These results suggest that the redundancy of octamer-binding proteins in vivo (Oct-1) can likely compensate for the loss of Oct-2, but that Oct-1 and Oct-2 have different functions, which may be distinguished using different target genes.
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(1993)
EMBO J
, vol.12
, pp. 2753-2772
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-
Feldhaus1
Klug2
Arvin3
Singh4
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22
-
-
0026693624
-
A Novel B Cell-Derived Coactivator Potentiates the Activation of Immunoglobulin Promoters by Octamer-Binding Transcription Factors
-
of special interest, The ubiquitous octamer-binding protein Oct-1 associates with OCA-B which does not itself bind DNA. Together, the Oct-1-OCA-B complex can activate the B cell specific Ig heavy chain promoter, but not other promoters containing octamer sites. OCA-B is the first example of a lymphoid-specific coactivator.
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(1992)
Cell
, vol.71
, pp. 231-241
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-
Luo1
Fujii2
Gerster3
Roeder4
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24
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-
0026575295
-
A Pre-B- and B Cell-Specific DNA-Binding Protein, EBB-1, which Binds to the Promoter of the VpreBl gene
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(1992)
Eur J Immunol
, vol.22
, pp. 37-43
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Okabe1
Watanabe2
Kudo3
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27
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0025943384
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LyF-1, a Transcriptional Regulator That Interacts with a Novel Class of Promoters for Lymphocyte-Specific Genes
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(1991)
Mol Cell Biol
, vol.11
, pp. 5229-5243
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Lo1
Landau2
Smale3
-
28
-
-
0027230072
-
Both LyF-1 and an Ets Protein Interact with a Critical Promoter Element in the Murine Terminal Transferase Gene
-
of special interest, The lymphocyte-enriched nuclear factor LyF-1 interacts with an important promoter element together with an Ets protein to form a multiprotein complex.
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(1993)
Mol Cell Biol
, vol.13
, pp. 2982-2992
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Ernst1
Hahm2
Smalf3
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29
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-
0026451087
-
Ikaros, an Early Lymphoid-Specific Transcription Factor and a Putative Mediator for T Cell Commitment
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of outstanding interest, Describes the cloning of the gene encoding Ikaros, a zinc finger protein which binds the CD3δ enhancer. Ikaros may be important for early stage-specific gene expression in both the B- and T-cell lineages.
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(1992)
Science
, vol.258
, pp. 808-812
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Georgopoulis1
Moore2
Derfler3
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30
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-
0025946134
-
Heterogeniously Initiated Transcription from the Pre-B- and B-Cell-Specific mb-1 Promoter: Analysis of the Requirement for Upstream Factor Binding Sites and Initiation Site Sequences
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(1991)
Mol Cell Biol
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Travis1
Hagman2
Grosschedi3
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31
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0026730324
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An Inhibitory Carboxyl-Terminal Domain in Ets-1 and Ets-2 Mediates Differential Binding of ETS Family Factors to Promoter Sequences of the mb-1 Gene
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(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 8889-8893
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Hagman1
Grosschedl2
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32
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0026006396
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A Novel Lineage-Specific Nuclear Factor Regulates mb-1 Gene Transcription at the Early Stages of B Cell Differentiation
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(1991)
EMBO J
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, pp. 3409-3417
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Hagman1
Travis2
Grosschedi3
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34
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0027316156
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NF-HB is a Repressor of the Murine Immunoglobulin Heavy-Chain 3′α Enhancer at Early Stages of B-Cell Differentiation
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(1993)
Mol Cell Biol
, vol.13
, pp. 3611-3622
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Singh1
Birshtein2
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35
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0024330616
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A B-Cell-Specific Nuclear Protein That Binds to DNA Sites 5′ to Ig Sα Tandem Repeats is Regulated during Differentiation
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(1989)
Mol Cell Biol
, vol.9
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Waters1
Saikh2
Stavnezer3
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36
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0026514486
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A Nuclear DNA-Binding Protein Expressed During Early Stages of B Cell Differentiation Interacts with Diverse Segments Within and 3′ of the Ig H Chain Gene Cluster
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(1992)
J Immunol
, vol.148
, pp. 2909-2917
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Liao1
Giannini2
Birshtein3
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37
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0026638191
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Properties of B Cell State Specific and Ubiquitous Nuclear Factors Binding to Ig Heavy Chain Gene Switch Regions
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1993
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(1992)
Int Immunol
, vol.4
, pp. 875-887
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-
Xu1
Kim2
Marcu3
-
39
-
-
0026698147
-
Pax-5 Encodes the Transcription Factor BSAP and is Expressed in B Lymphocytes, the Developing CNS, and Adult Testis
-
of outstanding interest, Cloning of cDNAs encoding BSAP (Pat-5) and characterization of the encoded protein as a member of the paired domain family of transcription factors. The paper contains extensive analysis of the expression pattern of the pax-5 gene during mouse emhryogenesis.
-
(1992)
Genes Dev
, vol.6
, pp. 1589-1607
-
-
Adams1
Dorfler2
Aguzzi3
Kozmik4
Urbanek5
Maurer-Fogy6
Busslinger7
-
41
-
-
0027426925
-
DNA Sequence Recognition by Pax Proteins: Bipartite Structure of the Paired Domain and its Binding Site
-
of special interest, BSAP (Pax-5) contains a paired domain, a DNA-binding motif that can be divided into two subdomains which recognize an extended sequence in adjacent major grooves of DNA. The interaction of two subdomains with DNA may account for the observed degenerate DNA-binding specificity of BSAP.
-
(1993)
Genes Dev
, vol.7
, pp. 2048-2061
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-
Czerny1
Schaffner2
Busslinger3
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42
-
-
0026527617
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Segments of the POU Domain Influence One Another's DNA-Binding Specificity
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(1992)
Mol Cell Biol
, vol.12
, pp. 455-467
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-
Aurora1
Herr2
-
44
-
-
0027229972
-
Cloning and Functional Characterization of Early B Cell Factor, a Regulator of Lymphocyte-Specific Gene Expression
-
of outstanding interest, Cloning of cDNAs encoding EBF, a transcriptional regulator of mb-1 gene expression. EBF contains multiple functional domains, including novel DNA-binding and dimerization motifs.
-
(1993)
Genes Dev
, vol.7
, pp. 760-773
-
-
Hagman1
Belanger2
Travis3
Turck4
Grosschedl5
-
45
-
-
0027213634
-
Molecular Cloning of the Olfactory Neuronal Transcription Factor OLF-1 by Genetic Selection in Yeast
-
of special interest, The authors used a functional assay in yeast to clone cDNAs encoding OLF-1, which is virtually identical to EBF. The cloning assay is of general use for the isolation of cDNAs encoding specific DNA-binding proteins.
-
(1993)
Nature
, vol.364
, pp. 121-126
-
-
Wang1
Reed2
-
47
-
-
0027327331
-
Genes Encoding Components of the Olfactory Signal Transduction Cascade Contain a DNA Binding Site That May Direct Neuronal Expression
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(1993)
Mol Cell Biol
, vol.13
, pp. 5805-5813
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-
Wang1
Tsai2
Schrader3
Reed4
-
49
-
-
0027458366
-
The Ets Family of Transcription Factors
-
of special interest, An up-to-date review on the role of Ets family proteins in normal gene regulation and oncogenesis.
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(1993)
Eur J Biochem
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, pp. 7-18
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-
Wasylyk1
Hahn2
Giovane3
-
51
-
-
0027163696
-
Regulation of Lymphoid-Specific Ig μ Heavy Chain Gene Enhancer by ETS-Domain Proteins
-
of special interest, Ets proteins co-operate with each other to regulate Ig μ enhancer function. The authors show that two distinct sites within the enhancer are recognized by PU.1 and Ets-1, respectively. Co-expression of the two factors in non-lymphoid cells transactivated a It enhancer fragment containing the two Ets binding sites and F boxes. This is the first evidence of Ets-1 function in B cells.
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(1993)
Science
, vol.261
, pp. 82-86
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-
Nelsen1
Tian2
Erman3
Gregoire4
Maki5
Graves6
Sen7
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54
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-
0025736350
-
Erythroleukemia Induction by Friend Murine Leukemia Virus: Insertional Activation of a New Member of the Ets Gene Family, Fli-1, Closely Linked to c-ets-1
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(1991)
Genes Dev
, vol.5
, pp. 908-918
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Ben-David1
Giddens2
Letwin3
Bernstein4
-
56
-
-
0027382099
-
Ets Proteins: New Factors That Regulate Ig Heavy-Chain Gene Expression
-
of special interest, Similar to the study by Nelsen et al. [51•], the authors show that two sites in the Ig μ enhancer are targets of Ets family proteins, but also demonstrate cooperation of these proteins with the bHLH protein E12 to activate gene expression. The paper also describes the cloning of the gene encoding Erg-3, an Ets family protein which recognizes the μ enhancer π box.
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(1993)
Mol Cell Biol
, vol.13
, pp. 7163-7169
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-
Rivera1
Stuiver2
Steenuergen3
Murre4
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57
-
-
0025279892
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Complex Regulation of the Ig Heavy Chain Gene Enhancer: μB, A New Determinant of Enhancer Function
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(1990)
Mol Cell Biol
, vol.10
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Nelsen1
Kadesch2
Sen3
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60
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-
0027494858
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PU.1 is a Component of a Multiprotein Complex Which Binds an Essential Site in the Murine Ig λ2–4 Enhancer
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(1993)
Mol Cell Biol
, vol.13
, pp. 6452-6461
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-
Eisenibeis1
Singh2
Store3
-
61
-
-
0027474319
-
Effect of PU.1 Phosphorylation on Interaction with NF-EM5 and Transcriptional Activation
-
of oustanding interest, An example of both a post-translational modification and an obligate interaction between two transcription factors in B cells. NF-EM5 only binds DNA together with PU.1, which must be phosphorylated by casein kinase II for the interaction to occur.
-
(1993)
Science
, vol.259
, pp. 1622-1625
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-
Pongiiiialla1
Van Beveren2
Nagulapalli3
Klemsz4
McKercher5
Maki6
Atchison7
-
63
-
-
0027371316
-
Ets-Related Protein PU.1 Regulates Expression of the Ig J-Chain Gene Through a Novel Ets-Binding Element
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(1993)
Genes Dev
, vol.7
, pp. 2006-2015
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Shin1
Koshland2
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64
-
-
0024554495
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A New DNA Binding and Dimerization Motif in Ig Enhancer Binding, daughterless, MyoD, and Myc Proteins
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(1989)
Cell
, vol.56 p
, pp. 777-783
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Murre1
McCaw2
Baltimore3
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66
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0026020867
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An Inhibitory Domain of F12 Transcription Factor Prevents DNA Binding in E12 Homodimers But Not in E12 Heterodimers
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(1991)
Cell
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, pp. 459-470
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Sun1
Baltimore2
-
68
-
-
0027215177
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E2A and E2-2 Are Subunits of Bell-Specific E2-Box DNA-Binding Proteins
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of special interest, BCF appears to comprise different polypeptides in pre-B versus mature B cells. The E2-2 gene may be downregulated after the pre-B cell stage.
-
(1993)
Mol Cell Biol
, vol.13
, pp. 3522-3529
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-
Bain1
Gruenwald2
Murre3
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69
-
-
0026798829
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Helix-Loop-Helix Proteins in the Regulation of Ig Gene Transcription
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of outstanding special, A brief, yet concise review of the role of bHLH and related proteins for the regulation of Ig-gene expression.
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(1992)
Immunol Today
, vol.13
, pp. 31-36
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-
Kadesch1
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70
-
-
0027386142
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Kinetics of E2A Basic Helix-Loop-Helix Expression During Myelopoiesis and Primary B Cell Differentiation
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of special interest, The onset of E2A gene expression is examined relative to other 13-cell markers in differentiating cultures of bone marrow cells.
-
(1993)
J Immunol
, vol.151
, pp. 5398-5407
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-
Xin1
Nelson2
Collins3
Dorshkind4
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71
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0026045243
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Helix-Loop-Helix Transcription Factor F47 Activates Germ-Line Ig Heavy-Chain Gene Transcription and Rearrangement in a Pre-T-Cell Line
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(1991)
Genes Dev
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Schlissel1
Voronova2
Baltimore3
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73
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0027422972
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E2A Expression, Nuclear Localization, and in Vivo Formation of DNA- and Non-DNA-Binding Species during B-Cell Development
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(1993)
Mol Cell Biol
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Jacobs1
Vierra2
Nelson3
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78
-
-
0026517310
-
Interleukin-7 Induces N-myc and C-myc Expression in Normal Prescursor B Lymphocytes
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of special interest, N-myc is regulated in pre-B cells by the lymphokine IL-7. IL-7 stimulated both N-myc and c-myc transcription in freshly isolated pre-B cells, but only c-myc was stimulated during mitogen-induced proliferation in more mature B cells. N-myc induction results from release of RNA polymerase from an attenuation block. N-myc is constitutively expressed only in transformed B cells with a pre-B cell phenotype.
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(1992)
Gen Dev
, vol.6
, pp. 61-70
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Morrow1
Lee2
Gillis3
Yancopoulos4
Alt5
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83
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A Thymus-Specific Member of the HMG Protein Family Regulates the Human T Cell Receptor a Enhance-
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(1991)
Genes Dev
, vol.5
, pp. 656-669
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Waterman1
Fischer2
Jones3
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