Immunological determinants of nerve growth factor involved in p140trk (Trk) receptor binding

Journal of Neuroscience Research

Volumn 37, Issue 4, 1994, Pages 433-444

  Nanduri, J ^a   Vroegop, S M ^b   Buxser, S E ^b   Neet, K E ^a  

^a ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

^b PFIZER INC   (United States)

Author keywords

epitope; monoclonal antibody; nerve growth factor receptor; neurotrophin

Indexed keywords

EPITOPE; MONOCLONAL ANTIBODY; NERVE GROWTH FACTOR; NERVE GROWTH FACTOR RECEPTOR; NEUROTROPHIN 3;

ANIMAL CELL; ANTIGENICITY; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL GROWTH; CELL SURVIVAL; COMPETITIVE INHIBITION; MOUSE; NERVE CELL; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; RECEPTOR BINDING;

ANIMAL; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; BINDING SITES; BINDING, COMPETITIVE; COMPARATIVE STUDY; CROSS REACTIONS; EPITOPES; MEMBRANE GLYCOPROTEINS; MICE; MODELS, MOLECULAR; NERVE GROWTH FACTORS; PC12 CELLS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, NERVE GROWTH FACTOR; RECEPTOR, TRKA; RECEPTORS, NERVE GROWTH FACTOR; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0028197337     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.490370402     Document Type: Article

References (57)

1. Detection of brain‐derived neuroutrophic factoer‐like activity in fabroblasts and Schwann cells: Inhibition by antibodies to NGF
2. Association of beta nerve growth factor with bovine serum albumin as well as with the alpha and gamma subunits of the 7S macromolecule
3. Nerve growth factor from mouse submaxillary gland: Amino acid sequence
4. Evidence for pro‐beta‐nerve growth factor, a biosynthetic precursor to beta‐nerve growth factor
5. Keeping track of neurotrophin receptors
6. Thermodynamics of interaction of the subunits of 7 S nerve growth factor
7. Monoclonal antibodies against mouse nerve growth factor produced by somatic cell hybrids
8. Antigenic sites on mouse 2.5S nerve growth factor
9. Three distinct types of monoclonal antibodies after long‐term immunization of rats with mouse nerve growth factor
10. A monoclonal antibody modulates the interaction of nerve growth factor with PC12 cells
11. Neurotrophin receptors: A window into neuronal differentiation
12. The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin‐3
13. Antibody‐antigen complexes
14. Mutation of tryptophan‐21 in mouse nerve growth factor (NGF) affects binding to the fast NGF receptor but not induction of neurites on PC12 cells
15. Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkins disease
16. Function and evolution in the NGF family and its receptors
17. The nerve growth factor: Biochemistry, synthesis, and mechanism of action
18. Molecular characteristics of nerve growth factor receptors on PC12 cells
19. Chimeric molecules with multiple neurotrophic activities reveal structural elements determining the specificites of NGF and BDNF
20. Disruption of the low affinity receptor‐binding site in NGF allows neuronal survival and differentiation by binding to the trk gene product
21. Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells
22. Role of glandular kallikreins as growth factor processing enzymes: Structural and evolutionary considerations
23. The amino terminus of nerve growth factor is involved in the interaction with the receptor tyrosine kinase p140trka
24. Tyrosine phosphorylation and tyrosine kinase activity of the trk proto‐oncogene product induced by NGF
25. The trk proto‐oncogene encodes a receptor for nerve growth factor
26. The trkB tyrosine protein kinase is a receptor for brain‐derived neurotrophic factor and neurotrophin‐3
27. Cleavage of structural proteins during assembly of the head of bacteriophage T4
28. trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin‐3
29. Molecular cloning and expression of brain‐derived neurotrophic factor
30. Placode and neural crestderived sensory neurons are responsive at early developmental stages to brain‐derived neurotrophic factor
31. The unprocessed C‐terminal dipeptide of recombinant beta‐nerve growth factor determines three stable forms with distinct biological activites
32. Characterization of the MRC OX40 antigen of activated CD4 positive T Iymphocytes: A molecule related to nerve growth factor receptor
33. New protein fold revealed by a 2.3‐A resolution erystal structure of nerve growth factor
34. Molecular investigations on the high affinity nerve growth factor receptor
35. Proteolytic modification of the beta nerve growth factor protein
36. Derivation of monoclonal antibody to nerve growth factor
37. Induction of apoptosis by the low‐affinity NGF receptor
38. Gene transfer and molecular cloning of the rat nerve growth factor receptor
39. The lack of a role for protein kinase C in neurite extension and in the induction of ornithine decarboxylase by nerve growth factor in PC12 cells
40. Binding of brain‐derived neurotrophic factor to the nerve growth factor receptor
41. Binding of neurotrophin‐3 to its neuronal receptors and interactions with nerve growth factor and brain‐derived neurotrophic factor
42. Nerve growth factor
43. A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins
44. Parkinson's disease. Fresh factors to consider [news]
45. The neurotrophic factors brain‐derived neurotrophic factor and neurotrophin‐3 are ligands for the trkB tyrosine kinase receptor
46. trkB encodes a functional receptor for brain‐derived neurotrophic factor and neurotrophin‐3 but not nerve growth factor
47. Characterization of the gamma subunits of the 7S nerve growth factor complex
48. A B‐lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas
49. NGF/BDNF chimeric proteins: Analysis of neurotrophin specificity by homolog‐scanning mutagenesis
50. Subunit structure of a highmolecular‐weight form of the nerve growth factor from mouse submaxillary gland
51. Reversible dissociation of the mouse nerve growth factor protein into different subunits
52. Probing the structure‐function relationship of nerve growth factor
53. Characterization of ultra‐high affinity monoclonal antibodies with a dimeric, symmetrical antigen: Inhibition of the receptor recognition site of nerve growth factor
54. Inhibition of biological activity of mouse beta nerve growth factor by monoclonal antibody
55. Inhibition of beta nerve growth factor binding to PC12 cells by alpha nerve growth factor and gamma nerve growth factor
56. Monoclonal antibodies against beta nerve growth factor and their effects on receptor binding and biological activity