Benzoxazolamines and Benzothiazolamines: Potent, Enantioselective Inhibitors of Leukotriene Biosynthesis with a Novel Mechanism of Action

Journal of Medicinal Chemistry

Volumn 37, Issue 7, 1994, Pages 913-923

  Lazer, Edward S ^a,b   Miao, Clara K ^a,b   Wong, Hin Chor ^a,b   Sorcek, Ronald ^a,b   Spero, Denice M ^a,b   Gilman, Alex ^a,b   Pal, Kollol ^a,b   Behnke, Mark ^a,b   Graham, Anne G ^a,b   Watrous, Jane M ^a,b   Homon, Carol A ^a,b   Nagel, Juergen ^a,b   Shah, Arvind ^a,b   Guindon, Yvan ^a,c   Farina, Peter R ^a,b   Adams, Julian ^a,b  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^b Department of Medicinal Chemistry ^*  (United States)

^c BOEHRINGER INGELHEIM CANADA LTD   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; 6 [[3 FLUORO 5 (3,4,5,6 TETRAHYDRO 4 METHOXY 2H PYRAN 4 YL)]PHENOXYMETHYL] 1 METHYL 2 QUINOLONE; ARACHIDONATE 5 LIPOXYGENASE; ARACHIDONIC ACID; CALCIMYCIN; ENOFELAST; ENZYME INHIBITOR; LEUKOTRIENE; LEUKOTRIENE B4; LEUKOTRIENE C4; LEUKOTRIENE D4; N (2 BENZOTHIAZOLYL)PHENYLALANINE ETHYL ESTER; N [2 CYCLOHEXYL 1 (2 PYRIDINYL)ETHYL] 5 METHYL 2 BENZOXAZOLAMINE; PHOSPHOLIPASE A2; UNCLASSIFIED DRUG; ZILEUTON;

ARACHIDONIC ACID METABOLISM; ARTICLE; ASTHMA; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; ENANTIOMER; ENTERITIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; INFLAMMATION; NORMAL HUMAN; PSORIASIS; RHEUMATOID ARTHRITIS; STRUCTURE ACTIVITY RELATION;

ARACHIDONIC ACID; BENZOXAZOLES; HUMAN; IN VITRO; LEUKOTRIENE ANTAGONISTS; LEUKOTRIENES; NEUTROPHILS; STEREOISOMERISM; THIAZOLES;

EID: 0028194945     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00033a008     Document Type: Article

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