Interleukin-1

Advances in Pharmacology

Volumn 25, Issue C, 1994, Pages 21-51

  Dinarello, Charles A ^a  

^a TUFTS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 6; SIALOGLYCOPROTEIN; TUMOR NECROSIS FACTOR;

ANIMAL; HUMAN; INFECTION; INFLAMMATION; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW;

ANIMAL; HUMAN; INFECTION; INFLAMMATION; INTERLEUKIN-1; INTERLEUKIN-6; SIALOGLYCOPROTEINS; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR NECROSIS FACTOR;

EID: 0028185699     PISSN: 10543589     EISSN: 15578925     Source Type: Book Series    
DOI: 10.1016/S1054-3589(08)60429-9     Document Type: Article

References (145)

1. Aiura, K., Gelfand, J.A., Wakabayashi, G., Callahan, M.V., Burke, J.F., Thompson, R.C., Dinarello, C.A., Interleukin-1 receptor antagonist blocks staphylococcal induced shock in rabbits. Cytokine, 3, 1991, 498 (abstr.).
2. Alexander, H.R., Doherty, G.M., Buresh, C.M., Venzon, D.J., Norton, J.A., A recombinant human receptor antagonist to interleukin-1 improves survival after lethal endotoxemia in mice. J. Exp. Med. 173 (1991), 1029–1032.
3. Arend, W.P., Interleukin-1 receptor antagonist. J. Clin. Invest. 88 (1991), 1445–1451.
4. Arend, W.P., Joslin, F.G., Massoni, R.J., Effects of immune complexes on production by human monocytes of interleukin 1 or an interleukin 1 inhibitor. J. Immunol. 134 (1985), 3868–3875.
5. Arend, W.P., Joslin, F.G., Thompson, R.C., Hannum, C.H., An IL-1 inhibitor from human monocytes. Production and characterization of biologic properties. J. Immunol. 143 (1989), 1851–1858.
6. Arend, W. P., Smith, M. F. J., Janson, R. W., and Joslin, F. G. (1991). IL-1 receptor antagonist and IL-1β production in human monocytes are regulated differently. J. Immunol. in press.
7. Auron, P.E., Warner, S.J., Webb, A.C., Cannon, J.G., Bernheim, H.A., McAdam, K.J., Rosenwasser, L.J., LoPreste, G., Mucci, S.F., Dinarello, C.A., Studies on the molecular nature of human interleukin 1. J. Immunol. 138 (1987), 1447–1456.
8. Bagby, G.C. Jr., Interleukin-1 and hematopoiesis. Blood Rev. 3 (1989), 152–161.
9. Bagby, G.C.J., Dinarello, C.A., Wallace, P., Wagner, C., Hefeneider, S., McCall, E., Interleukin 1 stimulates granulocyte macrophage colony-stimulating activity release by vascular endothelial cells. J. Clin. Invest. 78 (1986), 1316–1323.
10. Baggiolini, M., Walz, A., Kunkel, S.L., Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils. J. Clin. Invest. 84 (1989), 1045–1049.
11. Balavoine, J.F., de Rochemonteix, B., Williamson, K., Seckinger, P., Cruchaud, A., Dayer, J.M., Prostaglandin E2 and collagenase production by fibroblasts and synovial cells is regulated by urine-derived human interleukin 1 and inhibitor(s). J. Clin. Invest. 78 (1986), 1120–1124.
12. Barak, V., Treves, A.J., Yanai, P., Halperin, M., Wasserman, D., Biran, S., Braun, S., Interleukin-1 inhibitory activity secreted by a human myelomonocytic cell line (M20). Eur. J. Immunol. 16 (1986), 1449–1452.
13. Barak, V., Peritt, D., Flechner, I., Yanai, P., Halperin, T., Treves, A.J., Dinarello, C.A., The IL-1 specific inhibitor from the M20 cell line is distinct from the IL-1 receptor antagonist. Lymphokine Cytokine Res. 10 (1991), 437–442.
14. Beasley, D.S., Cohen, R.A., Levinsky, N.G., Interleukin-1 inhibits contraction of vascular smooth muscle. J. Clin. Invest. 83 (1989), 331–335.
15. Beasley, D., Schwartz, J.H., Brenner, B.M., Interleukin 1 induces prolonged L-arginine-dependent cyclic guanosine monophosphate and nitrite production in rat vascular smooth muscle cells. J. Clin. Invest. 87 (1991), 602–608.
16. Bertini, R., Bianchi, M., Ghezzi, P., Adrenalectomy sensitizes mice to the lethal effects of interleukin 1 and tumor necrosis factor. J. Exp. Med. 167 (1988), 1708–1712.
17. Beuscher, H.U., Nickells, M.W., Colten, H.R., The precursor of interleukin-1 alpha is phosphorylated at residue serine 90. J. Biol. Chem. 263 (1988), 4023–4028.
18. Beutler, B., Milsark, I.W., Cerami, A., Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin. Science 229 (1985), 869–871.
19. Bird, T.A., Davies, T., Baldwin, S.A., Saklatvala, J., Interleukin-1 regulates the glucose transporter of fibroblasts. J. Biol. Chem. 265 (1990), 13578–13583.
20. Black, R.A., Kronheim, S.R., Cantrell, M., Deeley, M.C., March, C.J., Prickett, K.S., Wignall, J., Conlon, P.J., Cosman, D., Hopp, T.P., et al. Generation of biologically active interleukin-1 beta by proteolytic cleavage of the inactive precursor. J. Biol. Chem. 263 (1988), 9437–9442.
21. Bottazzi, B., Nobili, N., Mantovani, A., Expression of c-fos proto-oncogene in tumor-associated macrophages. J. Immunol. 144 (1990), 4878–4882.
22. Bradley, T.R., Williams, N., Kriegler, A.B., Fawcett, J., Hodgson, G.S., In vivo effects of interleukin-1 alpha on regenerating mouse bone marrow myeloid colony forming cells after treatment with 5-fluorouracil. Leukemia 3 (1989), 893–896.
23. Cannon, J.G., van der Meer, J.W., Kwiatkowski, D., Endres, S., Lonnemann, G., Burke, J.F., Dinarello, C.A., Interleukin-1 beta in human plasma: Optimization of blood collection, plasma extraction, and radioimmunoassay methods. Lymphokine Res. 7 (1988), 457–467.
24. Cannon, J.G., Clark, B.D., Wingfield, P., Schmeissner, U., Losberger, C., Dinarello, C.A., Shaw, A.R., Rabbit IL-1. Cloning, expression, biologic properties, and transcription during endotoxemia. J. Immunol. 142 (1989), 2299–2306.
25. Cannon, J.G., Tompkins, R.G., Gelfand, J.A., Michie, H.R., Stanford, G.G., van der Meer, J.W.M., Endres, S., Lonnemann, G., Corsetti, J., Chernow, B., Wilmore, D.W., Wolff, S.M., Dinarello, C.A., Circulating interleukin-1 and tumor necrosis factor in septic shock and experimental endotoxin fever. J. Infect. Dis. 161 (1990), 79–84.
26. Cannon, J.G., Friedberg, J.S., Gelfand, J.A., Tompkins, R.G., Burke, J.F., Dinarello, C.A., Circulating interleukin-1β and tumor necrosis factor-α after burn injury in humans. Crit. Care Med. 20 (1992), 1414–1419.
27. Casey, L., Balk, R., Simpson, S., Modi, H., Motie, M., Rothenbach, P., Bone, R., Plasma tumor necrosis factor, interleukin-1 beta and endotoxin in patients with sepsis. Prog. Leuk. Biol. 10B (1990), 37–42.
28. Cerretti, D.P., Mosley, B., Kozlosky, C., Nelson, N., Van Ness, K., Greenstreet, T., Sleath, P.R., March, C.J., Kronheim, S.R., Black, R.A., Molecular cloning of the IL-1β processing enzyme. Cytokine, 3, 1991, 472 (abstr.).
29. Chizzonite, R., Truitt, T., Kilian, P.L., Stern, A.S., Nunes, P., Parker, K.P., Kaffka, K.L., Chua, A.O., Lugg, D.K., Gubler, U., Two high-affinity interleukin 1 receptors represent separate gene products. Proc. Natl. Acad. Sci. U.S.A. 86 (1989), 8029–8033.
30. Clark, B.D., Bedrosian, I., Schindler, R., Cominelli, F., Cannon, J.G., Shaw, A.R., Dinarello, C.A., Detection of interleukin-1α and 1β in rabbit tissues during endotoxemia using sensitive radioimmunoassays. J. Appl. Physiol. 71 (1991), 2412–2418.
31. Coceani, F., Lees, J., Dinarello, C.A., Occurrence of interleukin-1 in cerebrospinal fluid of the conscious cat. Brain Res. 446 (1988), 245–250.
32. Cominelli, F., Nast, C.C., Clark, B.D., Schindler, R., Llerena, R., Eysselein, V.E., Thompson, R.C., Dinarello, C.A., Interleukin-1 gene expression, synthesis and effect of specific IL-1 receptor blockade in rabbit immune complex colitis. J. Clin. Invest. 86 (1990), 972–980.
33. Cominelli, F., Nast, C.C., Llerena, R., Dinarello, C.A., Zipser, R.D., Interleukin-1 suppresses inflammation in rabbit colitis: Mediation by endogenous prostaglandins. J. Clin. Invest. 85 (1990), 582–586.
34. Dayer-Metroz, M.D., Wollheim, C.B., Seckinger, P., Dayer, J.M., A natural interleukin 1 (IL-1) inhibitor counteracts the inhibitory effect of IL-1 on insulin production in cultured rat pancreatic islets. J. Autoimmun. 2 (1989), 163–171.
35. Dayer-Metroz, M.D., Duhamel, D., Rufer, N., Izui, S., Carmichaels, D., Wollheim, C.B., Dayer, J.-M., IL-lra delays the spontaneous autoimmune diabetes in the BB rat. Eur. J. Clin. Invest., 22, 1992, A50 (abstr.).
36. Dejana, E., Breviario, F., Erroi, A., Bussolino, F., Mussoni, L., Gramse, M., Pintucci, G., Casali, B., Dinarello, C.A., Van Damme, J., Mantovani, A., Modulation of endothelial cell functions by different molecular species of interleukin 1. Blood 69 (1987), 695–699.
37. Demetri, G.D., Zenzie, B.W., Rheinwald, J.G., Griffin, J.D., Expression of colony-stimulating factor genes by normal human mesothelial cells and human malignant mesothelioma cell lines in vitro. Blood 74 (1989), 940–946.
38. Dinarello, C.A., Interleukin-1 and interleukin-1 antagonism. Blood 77 (1991), 1627–1652.
39. Dinarello, C.A., Thompson, R.C., Blocking IL-1: Effects of IL-1 receptor antagonist in vitro and in vivo. Immunol. Today 12 (1991), 404–410.
40. Dinarello, C.A., Wolff, S.M., The role of interleukin-1 in disease. N. Engl. J. Med. 328 (1993), 106–113.
41. Dinarello, C.A., Rosenwasser, L.J., Wolff, S.M., Demonstration of a circulating suppressor factor of thymocyte proliferation during endotoxin fever in humans. J. Immunol. 127 (1981), 2517–2519.
42. Dinarello, C.A., Ikejima, T., Warner, S.J., Orencole, S.F., Lonnemann, G., Cannon, J.G., Libby, P., Interleukin 1 induces interleukin 1. I. Induction of circulating interleukin 1 in rabbits in vivo and in human mononuclear cells in vitro. J. Immunol. 139 (1987), 1902–1910.
43. Dinarello, C.A., Cannon, J.G., Mancilla, J., Bishai, I., Lees, J., Coceani, F., Interleukin-6 as an endogenous pyrogen: Induction of prostaglandin E2 in brain but not in peripheral blood mononuclear cells. Brain Res. 562 (1991), 199–206.
44. Dripps, D.J., Brandhuber, B.J., Thompson, R.C., Eisenberg, S.P., Effect of IL-lra on IL-1 signal transduction. J. Biol. Chem. 266 (1991), 10331–10336.
45. Endres, S., Cannon, J.G., Ghorbani, R., Dempsey, R.A., Sisson, S.D., Lonnemann, G., van der Meer, J.W.M., Wolff, S.M., Dinarello, C.A., In vitro production of IL-1beta, IL-1alpha, TNF, and IL-2 in healthy subjects: Distribution, effect of cyclooxy-genase inhibition and evidence of independent gene regulation. Eur. J. Immunol. 19 (1989), 2327–2333.
46. Ernst, T.J., Ritchie, A.R., Demetri, G.D., Griffin, J.D., Regulation of granulocyte- and monocyte-colony stimulating factor mRNA levels in human blood monocytes is mediated primarily at a post-transcriptional level. J. Biol. Chem. 264 (1989), 5700–5703.
47. Estrov, Z., Kurzrock, R., Wetzler, M., Kantarjian, H., Blake, M., Harris, D., Gutterman, J.U., Talpaz, M., Suppression of CML colony growth by IL-1 receptor antagonist and soluble IL-1 receptors: A novel application for inhibitors of IL-1 activity. Blood 78 (1991), 1476–1484.
48. Faherty, D.A., Claudy, V., Plocinski, J.M., Kaffka, K., Kilian, P., Thompson, R.C., Benjamin, W.R., Failure of IL-1 receptor antagonist and monoclonal anti-IL-1 receptor antibody to inhibit antigen-specific immune responses in vivo. J. Immunol. 148 (1992), 766–771.
49. Fanslow, W.C., Sims, J.E., Sassenfeld, H., Morrissey, P.J., Gillis, S., Dower, S.K., Widmer, M.B., Regulation of alloreactivity in vivo by a soluble form of the interleukin-1 receptor. Science 248 (1990), 739–742.
50. Fibbe, W.E., van der Meer, J.W.M., Falkenburg, J.H.F., Hamilton, M.S., Kluin, P.M., Dinarello, C.A., A single low dose of human recombinant interleukin 1 accelerates the recovery of neutrophils in mice with cyclophosphamide-induced neutropenia. Exp. Hematol. 17 (1989), 805–808.
51. Fischer, E., Marano, M.A., Barber, A.E., Hudson, A.A., Lee, K., Rock, C.S., Hawes, A.S., Thompson, R.C., Hayes, T.V.A.T., Benjamin, W.R., Lowry, S.F., Moldawer, L.L., A comparison between the effects of interleukin-1α administration and sublethal endotoxemia in primates. Am. J. Physiol. 261 (1991), R442–R449.
52. Fischer, E., Marano, M.A., van Zee, K.J., Hawes, A.S., Rock, C.S., Kenney, J.S., Remick, D.G., Bloedow, D.C., Hudson, A.A., Thompson, R.C., Lowry, S.F., Moldawer, L.L., IL-1 receptor blockade improves survival and hemodynamic performance in E. coli septic shock, but fails to alter host responses to sublethal endotoxemia. J. Clin. Invest. 89 (1992), 1551–1557.
53. Fischer, E., van Zee, K.J., Marano, M.A., Rock, C.S., Kenney, J.S., Poutsiaka, D.D., Dinarello, C.A., Lowry, S.F., Moldawer, L.L., Interleukin-1 receptor antagonist circulates in experimental inflammation and in human disease. Blood 79 (1992), 2196–2200.
54. Fisher, C. J. J., Slotman, G. J., Opal, S., Pribble, J., Stiles, D., Catalano, M., and Group, I.-1. R. A. S. (1993). Interleukin-1 receptor antagonist reduces mortality in patients with sepsis syndrome. N. Engl. J. Med. submitted.
55. Flores, E.A., Bistrian, B.R., Pomposelli, J.J., Dinarello, C.A., Blackburn, G.L., Istfan, N.W., Infusion of tumor necrosis factor/cachectin promotes muscle catabolism in the rat. A synergistic effect with interleukin 1. J. Clin. Invest. 83 (1989), 1614–1622.
56. Fong, Y., Tracey, K.J., Moldawer, L.L., Hesse, D.G., Manogue, K.B., Kenney, J.S., Lee, A.T., Kuo, G.C., Allison, A.C., Lowry, S.F., Cerami, A., Antibodies to cachectin/tumor necrosis factor reduce interleukin 1β and interleukin 6 appearance during lethal bacteremia. J. Exp. Med. 170 (1989), 1627–1633.
57. Gershenwald, J.E., Fong, Y.M., Fahey, T.J., Calvano, S.E., Chizzonite, R., Kilian, P.L., Lowry, S.F., Moldawer, L.L., Interleukin 1 receptor blockade attenuates the host inflammatory response. Proc. Natl. Acad. Sci. U.S.A. 87 (1990), 4966–4970.
58. Ghiara, P., Armellini, D., Scapigliati, G., Nuti, S., Nucci, D., Bugnoli, M., Censini, S., Villa, L., Tagliabue, A., Bossu, P., Boraschi, D., Biological role of the IL-1 receptor type II as defined by a monoclonal antibody. Cytokine, 3, 1991, 473 (abstr.).
59. Giri, J., Newton, R.C., Horuk, R., Identification of soluble interleukin-1 binding protein in cell-free supernatants. J. Biol. Chem. 265 (1990), 17416–17419.
60. Granowitz, E.V., Santos, A., Poutsiaka, D.D., Cannon, J.G., Wilmore, D.A., Wolff, S.M., Dinarello, C.A., Circulating interleukin-1 receptor antagonist levels during experimental endotoxemia in humans. Lancet 338 (1991), 1423–1424.
61. Granowitz, E.V., Porat, R., Mier, J.W., Pribble, J.P., Stiles, D.M., Bloedow, D.C., Catalano, M.A., Wolff, S.M., Dinarello, C.A., Pharmacokinetics, safety, and immunomodulatory effects of human recombinant interleukin-1 receptor antagonist in healthy humans. Cytokine 4 (1992), 353–360.
62. Griffin, J.D., Cannistra, S.A., Sullivan, R., Demetri, G.D., Ernst, T.J., Kanakura, Y., The biology of GM-CSF: Regulation of production and interaction with its receptor. Int. J. Cell Cloning 1 (1990), 35–44.
63. Grunfeld, C., Soued, M., Adi, S., Moser, A.H., Dinarello, C.A., Feingold, K.R., Evidence for two classes of cytokines that stimulate hepatic lipogenesis: Relationships among tumor necrosis factor, interleukin-1 and interferon-alpha. Endocrinology (Baltimore) 127 (1990), 46–52.
64. Guenard, V., Dinarello, C.A., Weston, P.J., Aebischer, P., Peripheral nerve regeneration is impeded by interleukin-1 receptor antagonist released from a polymeric guidance channel. J. Neurosci. Res. 29 (1991), 396–400.
65. Haskill, S., Martin, M., VanLe, L., Morris, J., Peace, A., Bigler, C.F., Jaffe, G.J., Sporn, S.A., Fong, S., Arend, W.P., Ralph, P., CDNA cloning of a novel form of the interleukin-1 receptor antagonist associated with epithelium. Proc. Natl. Acad. Sci. U.S.A. 88 (1991), 3681–3685.
66. Hellerstein, M.K., Meydani, S.N., Meydani, M., Wu, K., Dinarello, C.A., Interleukin-1-induced anorexia in the rat. Influence of prostaglandins. J. Clin. Invest. 84 (1989), 228–235.
67. Henricson, B.E., Neta, R., Vogel, S.N., An interleukin-1 receptor antagonist blocks lipopolysaccharide-induced colony-stimulating factor production and early endotoxin tolerance. Infect. Immun. 59 (1991), 1188–1191.
68. Holtmann, H., Wallach, D., Down regulation of the receptors for tumor necrosis factor by interleukin 1 and 4 beta-phorbol-12-myristate-13-acetate. J. Immunol. 139 (1987), 1161–1167.
69. Ikejima, T., Okusawa, S., van der Meer, J.W., Dinarello, C.A., Induction by toxic-shock-syndrome toxin-1 of a circulating tumor necrosis factor-like substance in rabbits and of immunoreactive tumor necrosis factor and interleukin-1 from human mononuclear cells. J. Infect. Dis. 158 (1988), 1017–1025.
70. Jacobs, C.A., Baker, P.E., Roux, E.R., Picha, K.S., Toivola, B., Waugh, S., Kennedy, M.K., Experimental autoimmune encephalomyelitis is exacerbated by IL-1α and suppressed by soluble IL-1 receptor. J. Immunol. 146 (1991), 2983–2989.
71. Knudsen, P.J., Dinarello, C.A., Strom, T.B., Purification and characterization of a unique human interleukin 1 from the tumor cell line U937. J. Immunol. 136 (1986), 3311–3316.
72. Kostura, M.J., Tocci, M.J., Limjuco, G., Chin, J., Cameron, P., Hillman, A.G., Chartrain, N.A., Schmidt, J.A., Identification of a monocyte specific pre-interleukin 1 beta convertase activity. Proc. Natl. Acad. Sci. U.S.A. 86 (1989), 5227–5231.
73. Larrick, J.W., Native interleukin-1 inhibitors. Immunol. Today 10 (1989), 61–66.
74. Lewis, C., Mazzei, G., Shaw, A., Monoclonal antibodies reacting with the interleukin 1 receptor define a multi-molecular complex. Eur. J. Immunol. 20 (1990), 207–213.
75. Lonnemann, G., Endres, S., van der Meer, J.W., Cannon, J.G., Koch, K.M., Dinarello, C.A., Differences in the synthesis and kinetics of release of interleukin 1 alpha, interleukin 1 beta and tumor necrosis factor from human mononuclear cells. Eur. J. Immunol. 19 (1989), 1531–1536.
76. Luger, A., Graf, H., Schwarz, H.-P., Stummvoll, H.-K., Luger, T.A., Decreased serum interleukin-1 activity and monocyte interleukin-1 production in patients with fatal sepsis. Crit. Care Med. 14 (1986), 458–461.
77. Maier, J.A.M., Voulalas, P., Roeder, D., Maciag, T., Extension of the life span of human endothelial cells by an interleukin-1α antisense oligomer. Science 249 (1990), 1570–1574.
78. Mancilla, J., Garcia, P., Dinarello, C.A., IL-1 receptor antagonist can either protect or enhance the lethality of Klebsiella pneumoniae sepsis in newborn rats. Infect. Immun. 61 (1993), 926–932.
79. Mandrup-Poulsen, T., Bendtzen, K., Dinarello, C.A., Nerup, J., Potentiation of IL-1 mediated B-cell killing by TNF. Human tumor necrosis factor potentiates human interleukin 1-mediated rat pancreatic beta-cell cytotoxicity. J. Immunol. 139 (1987), 4077–4082.
80. Mazzei, G.J., Seckinger, P.L., Dayer, J.M., Shaw, A.R., Purification and characterization of a 26-kDa competitive inhibitor of interleukin 1. Eur. J. Immunol. 20 (1990), 683–689.
81. McCarthy, P.L., Abhyankar, S., Neben, S., Sieff, C., Thompson, R.C., Burakoff, S., Ferrara, J.L.M., Inhibition of interleukin-1 by interleukin-1 receptor antagonist prevents graft versus host disease. Blood 78 (1991), 1915–1918.
82. McIntyre, K.W., Stepan, G.J., Kolinsky, D.K., Benjamin, W.R., Plocinski, J.M., Kaffka, K.L., Campen, R.A., Chizzonite, R.A., Kilian, P.L., Interleukin-1 receptor antagonist blocks acute inflammatory responses to IL-1 and other agents in vivo. J. Exp. Med. 173 (1991), 931–939.
83. McNiece, I., Langely, K., Zsebo, K., Recombinant human stem cell factor synergizes with CSF's and EPO to stimulate colony formation of myeloid and erythroid cells. Blood, Suppl., 76, 1990, 154a (abstr.).
84. Michie, H.R., Manogue, K.R., Spriggs, D.R., Revhaug, A., O'Dwyer, S., Dinarello, C.A., Cerami, A., Wolff, S.M., Wilmore, D.W., Detection of circulating tumor necrosis factor after endotoxin administration. N. Engl. J. Med. 318 (1988), 1481–1486.
85. Mizutani, H., Schecter, N., Zazarus, G., Black, R.A., Kupper, T.S., Rapid and specific conversion of precursor interleukin-1β to an active IL-1 species by human mast cell chymase. J. Exp. Med. 174 (1991), 821–825.
86. Moldawer, L.L., Andersen, C., Gelin, J., Lundholm, K.G., Regulation of food intake and hepatic protein synthesis by recombinant derived cytokines. Am. J. Physiol. 254 (1988), G450–G456.
87. Moore, M.A., Warren, D.J., Synergy of interleukin 1 and granulocyte colony-stimulating factor: In vivo stimulation of stem-cell recovery and hematopoietic regeneration following 5-fluorouracil treatment of mice. Proc. Natl. Acad. Sci. U.S.A. 84 (1987), 7134–7138.
88. Movat, H.Z., Burrowes, C.E., Cybulsky, M.I., Dinarello, C.A., Acute inflammation and a Shwartzman-like reaction induced by interleukin-1 and tumor necrosis factor. Synergistic action of the cytokines in the induction of inflammation and microvascular injury. Am. J. Pathol. 129 (1987), 463–476.
89. Mrosovsky, N., Molony, L.A., Conn, C.A., Kluger, M.J., Anorexic effects of interleukin-1 in the rat. Am. J. Physiol. 257 (1989), R1315–R1321.
90. Neta, R., Sztein, M.B., Oppenheim, J.J., Gillis, S., Douches, S.D., The in vivo effects of interleukin-1. I. Bone marrow cells are induced to cycle after administration of interleukin-1. J. Immunol. 139 (1987), 1861–1866.
91. Neta, R., Oppenheim, J.J., Douches, S.D., Interdependence of the radioprotective effects of human recombinant interleukin 1 alpha, tumor necrosis factor alpha, granulocyte colony-stimulating factor, and murine recombinant granulocyte-macrophage colony-stimulating factor. J. Immunol. 140 (1988), 108–111.
92. Neta, R.S.N.V., Plocinski, J.M., Parenes, S., Benjamin, W., Chizzonite, R., Pilcher, M., In vivo modulation with anti IL-1 receptor (p80) antibody 35F5 of the response to IL-1. Blood 76 (1990), 57–62.
93. Nicod, L., and Dayer, J.-M. (1991). Effect of IL-1 receptor antagonist on mitogenic and antigenic response of human peripheral blood mononuclear cells in vitro. J. Immunol. in press.
94. Novick, D., Engelmann, H., Wallach, D., Rubinstein, M., Soluble cytokine receptors are present in normal human urine. J. Exp. Med. 170 (1989), 1409–1414.
95. Novick, D., Engelmann, H., Wallach, D., Leitner, O., Revel, M., Rubinstein, M., Purification of soluble cytokine receptors from normal human urine by ligand-affinity and immunoaffinity chromatography. J. Chromatogr. 510 (1990), 331–337.
96. Numerof, R.P., Aronson, F.R., Mier, J.W., IL-2 stimulates the production of IL-1α and IL-1β by human peripheral blood mononuclear cells. J. Immunol. 141 (1988), 4250–4257.
97. Numerof, R.P., Kotick, A.N., Dinarello, C.A., Mier, J.W., Pro-interleukin-1β production by a subpopulation of human T cells, but not NK cells, in response to interleukin-2. Cell. Immunol. 130 (1990), 118–128.
98. Ohlsson, K., Bjork, P., Bergenfeldt, M., Hageman, R., Thompson, R.C., Interleukin-1 receptor antagonist reduces mortality from endotoxin shock. Nature (London) 348 (1990), 550–552.
99. Okusawa, S., Gelfand, J.A., Ikejima, T., Connolly, R.J., Dinarello, C.A., Interleukin 1 induces a shock-like state in rabbits. Synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition. J. Clin. Invest. 81 (1988), 1162–1172.
100. Oppenheim, J.J., Neta, R., Tiberghien, P., Gress, R., Kenny, J.J., Longo, D.L., Interleukin-1 enhances survival of lethally irradiated mice treated with allogeneic bone marrow cells. Blood 74 (1989), 2257–2263.
101. Porat, R., Poutsiaka, D.D., Miller, L.C., Granowitz, E.V., Dinarello, C.A., Interleukin-1 (IL-1) receptor blockade reduces endotoxin and Borrelia burgdorferi-stimulated IL-8 synthesis in human mononuclear cells. FASEB J. 6 (1992), 2482–2486.
102. Poutsiaka, D.D., Clark, B.D., Vannier, E., Dinarello, C.A., Production of interleukin-1 receptor antagonist and interleukin-1β by peripheral blood mononuclear cells is differentially regulated. Blood 78 (1991), 1275–1281.
103. Prieur, A.M., Kaufmann, M.T., Griscelli, C., Dayer, J.M., Specific interleukin-1 inhibitor in serum and urine of children with systemic juvenile chronic arthritis. Lancet 2 (1987), 1240–1242.
104. Ramadori, G., Sipe, J.D., Dinarello, C.A., Mizel, S.B., Colten, H.R., Pretransla- tional modulation of acute phase hepatic protein synthesis by murine recombinant interleukin 1 (IL-1) and purified human IL-1. J. Exp. Med. 162 (1985), 930–942.
105. Rambaldi, A., Torcia, M., Bettoni, S., Barbui, T., Vannier, E., Dinarello, C.A., Cozzolino, F., Modulation of cell proliferation and cytokine production in acute myeloblastic leukemia by interleukin-1 receptor antagonist and lack of its expression by leukemic cells. Blood 78 (1991), 3248–3253.
106. Rangnekar, V.V., Waheed, S., Rangnekar, V.M., Interleukin-1-inducible tumor growth arrest is characterized by activation of cell-type-specific “early” gene expression programs. J. Biol. Chem. 267 (1992), 6240–6248.
107. Revhaug, A., Michie, H.R., Manson, J.M., Watters, J.M., Dinarello, C.A., Wolff, S.M., Wilmore, D.W., Inhibition of cyclo-oxygenase attenuates the metabolic response to endotoxin in humans. Arch. Surg. 123 (1988), 162–170.
108. Rossi, V., Breviario, F., Ghezzi, P., Dejana, E., Mantovani, A., Prostacyclin synthesis induced in vascular cells by interleukin-1. Science 229 (1985), 174–176.
109. Sartor, R.B., Holt, L.C., Bender, D.E., Murphy, M.E., McCall, R.D., Thompson, R.C., Prevention and treatment of experimental enterocolitis with a recombinant interleukin-1 receptor antagonist. Gastroenterology, 100, 1991, A613 (abstr.).
110. Schindler, R., Mancilla, J., Endres, S., Ghorbani, R., Clark, S.C., Dinarello, C.A., Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF. Blood 75 (1990), 40–47.
111. Schwab, J.H., Anderle, S.K., Brown, R.R., Dalldorf, F.G., Thompson, R.C., Pro- and anti-inflammatory roles of IL-1 in recurrence of bacterial cell wall-induced arthritis in rats. Infect. Immun. 59 (1991), 4436–4442.
112. Schwartz, G.N., MacVittie, T.J., Vigneulle, R.M., Patchen, M.L., Douches, S.D., Oppenheim, J.J., Neta, R., Enhanced hematopoietic recovery in irradiated mice pretreated with interleukin-1 (IL-1). Immunopharmacol. Immunotoxicol. 9 (1987), 371–389.
113. Schweizer, A., Feige, U., Fontana, A., Muller, K., Dinarello, C.A., Interleukin-1 enhances pain reflexes. Mediation through increased prostaglandin E2 levels. Agents Actions 25 (1988), 246–251.
114. Seckinger, P., Dayer, J.M., Interleukin-1 inhibitors. Ann. Inst. Pasteur/Immunol. 138 (1987), 461–516.
115. Seckinger, P., Lowenthal, J.W., Williamson, K., Dayer, J.M., MacDonald, H.R., A urine inhibitor of interleukin-1 activity that blocks ligand binding. J. Immunol. 139 (1987), 1546–1549.
116. Seckinger, P., Klein-Nulend, J., Alander, C., Thompson, R.C., Dayer, J.M., Raisz, L.G., Natural and recombinant human IL-1 receptor antagonists block the effects of IL-1 on bone resorption and prostaglandin production. J. Immunol. 145 (1990), 4181–4184.
117. Shieh, J.-H., Gordon, M.S., Peterson, R.H.F., Jakubowski, A.A., Gabrilove, J.L., Moore, M.A.S., Modulation of cytokine receptors and superoxide production in neutrophils treated with IL-1 in vitro and in vivo. Blood, Suppl., 76, 1990, 165a (abstr.).
118. Smith, J., Urba, W., Steis, R., Janik, J., Fenton, B., Sharfman, W., Conlon, K., Sznol, M., Creekmore, S., Wells, N., Elwood, L., Keller, J., Hestdal, K., Ewel, C., Rossio, J., Kopp, W., Shimuzut, M., Oppenheim, J., Longo, D., Interleukin-1 alpha: Results of a phase I toxicity and immunomodulatory trial. Am. Soc. Clin. Oncol., 9, 1990, 717.
119. Starnes, H.F., Pearce, M.K., Twari, A., Yim, J.M., Zou, J.-C., Abrams, J.S., Anti-monoclonal antibodies protect against lethal Escherichia coli infection and lethal tumor necrosis factor-α challenge in mice. J. Immunol. 145 (1990), 4185–4191.
120. Symons, J.A., Eastgate, J.A., Duff, G.W., Purification and characterization of a novel soluble receptor for interleukin-1. J. Exp. Med. 174 (1991), 1251–1254.
121. Tewari, A., Buhles, W.C. Jr., Starnes, H.F. Jr., Preliminary report: Effects of interleukin-1 on platelet counts. Lancet 336 (1990), 712–714.
122. Thornberry, N.A., Bull, H.G., Calaycay, J.R., Chapman, K.T., Howard, A.D., Kostura, M.J., Miller, D.K., Molineaux, S.M., Weidner, J.R., Aunins, J., Schmidt, J.A., Tocci, M., A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. Nature (London) 356 (1992), 768–774.
123. Tracey, K., Fong, Y., Hesse, D.G., Manogue, K.R., Lee, A.T., Kuo, G.C., Lowry, S.F., Cerami, A., Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteremia. Nature (London) 330 (1987), 662–664.
124. Tredget, E.E., Yu, Y.M., Zhong, S., Burini, R., Okusawa, S., Gelfand, J.A., Dinarello, C.A., Young, V.R., Burke, J.F., Role of interleukin 1 and tumor necrosis factor on energy metabolism in rabbits. Am. J. Physiol. 255 (1988), E760–E768.
125. Ulich, T.R., del Castillo, J., Keys, M., Granger, G.A., Ni, R.-X., Kinetics and mechanisms of recombinant human interleukin 1 and tumor necrosis factor-α-induced changes in circulating numbers of neutrophils and lymphocytes. J. Immunol. 139 (1987), 3406–3415.
126. Ulich, T.R., Yin, S.M., Guo, K.Z., del Castillo, J., Eisenberg, S.P., Thompson, R.C., The intratracheal administration of endotoxin and cytokines. III. The interleukin-1 (IL-1) receptor antagonist inhibits endotoxin- and IL-1-induced acute inflammation. Am. J. Pathol. 138 (1991), 521–524.
127. Van Damme, J., De Ley, M., Opdenakker, G., Billiau, A., De Somer, P., Homogeneous interferon-inducing 22K factor is related to endogenous pyrogen and interleukin-1. Nature (London) 314 (1985), 266–268.
128. Van Damme, J., Opdenakker, G., De Ley, M., Heremans, H., Billiau, A., Pyrogenic and haematological effects of the interferon-inducing 22K factor (interleukin-1) from human leukocytes. Clin. Exp. Immunol. 66 (1986), 303–311.
129. van der Meer, J.W.M., Barza, M., Wolff, S.M., Dinarello, C.A., A low dose of recombinant interleukin 1 protects granulocytopenic mice from lethal gram-negative infection. Proc. Natl. Acad. Sci. U.S.A. 85 (1988), 1620–1623.
130. van der Meer, J.W.M., Curfs, J.H.A.J., Thompson, R.C., Eling, W.M.C., The effect of IL-lra in murine cerebral malaria. Cytokine, 3, 1991, 497 (abstr.).
131. Vannier, E., Lefort, J., Bachelet, M., Lelouch-Tubiana, A., Terlain, B., Vargastig, B.B., Lipopolysaccharide from E. coli modulates anaphylactic brochoconstriction of actively sensitized guinea pigs. Am. Rev. Respir. Dis., 139, 1989, A355.
132. Vannier, E., Miller, L. C., and Dinarello, C. A. (1992). Coordinated anti-inflammatory effect of IL-4:IL-4 downregulates IL-1 synthesis but upregulates IL-lra production. Proc. Natl. Acad. Sci. U.S.A. in press.
133. Wakabayashi, G., Gelfand, J.A., Burke, J.F., Thompson, R.C., Dinarello, C.A., A specific receptor antagonist for interleukin-1 prevents Escherichia coli-induced shock. FASEB J. 5 (1991), 338–343.
134. Wakabayashi, G., Gelfand, J.A., Jung, W.K., Connolly, R.J., Burke, J.F., Dinarello, C.A., Staphylococcus epidermidis induces complement activation, tumor necrosis factor and interleukin-1, a shock-like state and tissue injury in rabbits without endotoxemia. J. Clin. Invest. 87 (1991), 1925–1935.
135. Wallach, D., Holtmann, H., Engelmann, H., Nophar, Y., Sensitization and desensitization to lethal effects of tumor necrosis factor and IL-1. J. Immunol. 140 (1988), 2994–2999.
136. Wallach, D., Holtmann, H., Aderka, D., Rubinstein, M., Avni, Y.S., Sarov, I., Engelman, H., Mechanisms which take part in regulation of the response to tumor necrosis factor. Lymphokine Res. 8 (1989), 359–363.
137. Watters, J.M., Bessey, P.Q., Dinarello, C.A., Wolff, S.M., Wilmore, D.W., The induction of interleukin-1 in humans and its metabolic effects. Surgery 98 (1985), 298–306.
138. Watters, J.M., Bessey, P.Q., Dinarello, C.A., Wolff, S.M., Wilmore, D.W., Both inflammatory and endocrine mediators stimulate host responses to sepsis. Arch. Surg. 121 (1986), 179–190.
139. White, C.W., Ghezzi, P., Protection against pulmonary oxygen toxicity by interleukin-1 and tumor necrosis factor: role of antioxidant enzymes and effect of cycloox-ygenase inhibitors. Biotherapy 1 (1989), 361–367.
140. Wogensen, L.D., Mandrup, P.T., Markholst, H., Molvig, J., Lernmark, A., Hoist, J.J., Dinarello, C.A., Nerup, J., Interleukin-1 potentiates glucose stimulated insulin release in the isolated perfused pancreas. Acta Endocrinol. (Copenhagen) 117 (1988), 302–306.
141. Wooley, P.H., Whalen, J.D., Chapman, D.L., Berger, A.E., Aspar, D.G., Richard, K.A., Staite, N.D., The effect of an interleukin-1 receptor antagonist protein on type II collagen and antigen-induced arthritis in mice. Arthritis Rheum., 33, 1990, S20 (abstr.).
142. Ye, K., Koch, K.-C., Clark, B.D., Dinarello, C.A., Interleukin-1 downregulates gene and surface expression of interleukin-1 receptor type I by destabilizing its mRNA whereas interleukin-2 increases its expression. Immunology, 75, 1992 in press.
143. Young, P.R., Krasney, P.A., Interleukin-1β can be secreted from mammalian cells by the human MDR1 P-glycoprotein. Cytokine, 3, 1991, 472 (abstr.).
144. Zsebo, K.M., Yuschenkoff, V.N., Schiffer, S., Chang, D., McCall, E., Dinarello, C.A., Brown, M.A., Altrock, B., Bagby, G.C.J., Vascular endothelial cells and granulopoiesis: Interleukin-1 stimulates release of G-CSF and GM-CSF. Blood 71 (1988), 99–103.
145. Zucali, J.R., Dinarello, C.A., Oblon, D.J., Gross, M.A., Anderson, L., Weiner, R.S., Interleukin 1 stimulates fibroblasts to produce granulocyte-macrophage colony-stimulating activity and prostaglandin E2. J. Clin. Invest. 11 (1986), 1857–1863.