How does the G protein, Gi2, transduce mitogenic signals?

Journal of Cellular Biochemistry

Volumn 54, Issue 4, 1994, Pages 415-422

  Johnson, Gary L ^a,b   Gardner, Anne M ^a   Lange‐Carter, Carol ^a   Qian, Nan‐Xin ^a   Russell, Marijane ^a   Winitz, Sim ^a,b  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

DNA synthesis; Gi2; MAPKs; MEK; serpentine receptors

Indexed keywords

DNA; GTP BINDING PROTEINS; GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASES; MITOGENIC AGENT; PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; PROTEIN SERINE THREONINE KINASES; PROTEIN TYROSINE KINASE;

AMINO ACID SEQUENCE; ANIMAL; BIOSYNTHESIS; CHEMISTRY; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION; ANIMAL CELL; CONFERENCE PAPER; DNA SYNTHESIS; MITOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

AMINO ACID SEQUENCE; ANIMAL; DNA; GTP-BINDING PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGENS; MOLECULAR SEQUENCE DATA; P42 MAP KINASE; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASE; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0028183276     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.240540408     Document Type: Article

References (61)

1. Identification of multiple epidermal growth factor‐stimulated protein serine/threonine kinases from Swiss 3T3 cells
2. Multiple components in an epidermal growth factor‐stimulated protein kinase cascade
3. ERKs: a family of protein‐serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
4. Myristoylated α subunits of guanine nucleotide‐binding regulatory proteins
5. Two growth factor signalling pathways in fibroblasts distinguished by pertussis toxin
6. Purification of a murine protein‐tyrosine/theronine kinase that phosphorylates and activates the Erk‐1 gene product: relationship to the fission yeast byr 1 gene product
7. The primary structure of MEK, a protein kinase that phosphorylates and activates the ERK gene product
8. Activation of mitogen‐activated protein kinase by v‐Raf in NIH3T3 cells and in vitro
9. G proteins control diverse pathways of transmembrane signaling
10. Mitogen‐activated protein kinase activation resulting from selective oncogene expression in NIH3T3 and Rat 1a cells
11. Activation of MEK (MAPK/ERK Kinase) by G protein and tyrosine kinase oncoproteins
12. i protein subtypes regulate a single effector mechanism
13. Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinase
14. Xenopus M phase MAP kinase: isolation of its cDNA and activation by MPF
15. Mitogenic pathways regulated by G protein oncogenes
16. MAP kinase is constitutively activated in gip2 and src transformed Rat 1a fibroblasts
17. Analysis of the fibroblast transformation potential of GTPase‐deficient gip2 oncogenes
18. Activation of the MAP kinase pathway by the protein kinase raf
19. Raf‐1 protein kinase is an integral component of the oncogenic signal cascade shared by the epidermal growth factor and platelet‐derived growth factor
20. Xenopus MAP kinase activator is a serine/theronine/tyrosine kinase activated by threonine phosphorylation
21. cDNA cloning of MAP kinase kinase reveals kinase cascade pathways in yeasts to vertebrates
22. Raf‐1 activates MAP kinase‐kinase
23. p42/mitogen‐activated protein kinase as a converging target for different growth factor signalling pathways: use of pertussis toxin as a discrimination factor
24. i2
25. A Divergence in the MAP Kinase Regulatory Network Defined by MEK Kinase and Raf
26. Pertussis toxin‐sensitive pathway in the stimulation of c‐myc expression and DNA synthesis by bombesin
27. 2 is phosphorylated and activated by MAP kinase
28. Xenopus MAP kinase activator: identification and function as a key intermediate in the phosphorylation cascade
29. mapk
30. Possible involvement of a GTP‐binding protein, the substrate of islet‐activating protein, in receptor mediated signaling responsible for cell proliferation
31. A gene which encodes a predicted protein kinase can restore some functions of the ras gene in fission yeast
32. MAP kinase activator from insulin‐stimulated skeletal muscle is a protein threonine/tyrosine kinase
33. Phosphorylation and activation of a high molecular weight form of phospholipase A2 by p42 MAP kinase and protein kinase C
34. Isolation and characterization of two growth factor‐stimulated protein kinases that phosphorylate the epidermal growth factor receptor at threonine 669
35. i2 induces neoplastic transformation of Rat‐1 cells
36. Transmembrane receptors and intracellular pathways that control cell proliferation
37. Phosphorylation of c‐jun mediated by MAP kinases
38. Rapid stimulation by insulin of a serine/threonine kinase in 3T3‐L1 adipocytes that phosphorylates microtubule‐associated protein 2 in vitro
39. Insulin‐stimulated microtubule‐associated protein kinase in phosphorylated on tyrosine and threonine in vivo
40. Extracellular signal‐regulated kinase 2 autophosphorylates on a subset of peptides phosphorylated in intact cells in response to insulin and nerve growth factor: analysis by peptide mapping
41. Regulation and properties of extracellular signal‐regulated protein kinases 1 and 2 in vitro
42. mapk is a kinase with specificity for the threonine and tyrosine regulatory sites
43. Microtubule‐associated protein 2 kinases, ERK1 and ERK2, undergo autophophorylation on both tyrosine and threonine residues: implications for their mechanisms of activation
44. Purification and characterization of mitogen‐activated protein kinase activator(s) from epidermal growth factor‐stimulated A431 cells
45. Human T‐cell mitogen‐activated protein kinases are related to yeast signal transduction kinases
46. 2‐terminal domain of c‐Myc increases transactivation of gene expression
47. o to S phase progression in hampster fibroblasts
48. Constitutive mutants of the protein kinase STE11 activate the yeast pheromone response pathway in the absence of the G protein
49. Type‐specific regulation of adenyl cyclase by G protein βγ subunits
50. Adenylyl cyclases
51. Islet‐activating protein, pertussis toxin: a probe for functions of the inhibitory guanine nucleotide regulatory component of adenylate cyclase
52. ras by G protein‐coupled receptor agonists in fibroblasts
53. byr2, a Schizosaccharomyces pombe gene encoding a protein kinase capable of partial suppression of the ras1 mutant phenotype
54. i‐coupled acetylcholine muscarine receptor activation of mitogen‐activated protein (MAP) kinase kinase and MAP kinase
55. ras meditates nerve growth factor receptor modulation of three signal‐transducing protein kinases: MAP kinase, Raf‐1, and RSK
56. Autophosphorylation in vitro of recombinant 42‐kilodalton mitogen‐activated protein kinase on tyrosine
57. Molecular structure of a protein‐tyrosine/threonine kinase activating p42 mitogen‐activated protein (MAP) kinase: MAP kinase kinase
58. i alpha subunits
59. Increased mitogenic responsiveness of Swiss 3T3 cells expressing constitutively active Gsα
60. Bombesin, Vasopressin, and Endothelin Stimulation of Tyrosine Phosphorylation in Swiss 3T3 Cells