Differentiation of the Secondary B‐Lymphocyte Repertoire: The Germinal Center Reaction

Immunological Reviews

Volumn 137, Issue 1, 1994, Pages 173-183

  Nossal, G J V ^a  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; B LYMPHOCYTE; CELL DIFFERENTIATION; DENDRITIC CELL; GERM CELL; HUMAN; IMMUNOGLOBULIN GENE; IMMUNOLOGY; LYMPHOID TISSUE; MUTATION; PHYSIOLOGY; REVIEW; ANIMAL CELL; ANIMAL TISSUE; ANTIBODY RESPONSE; GERMINAL CENTER; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMAL; B-LYMPHOCYTES; CELL DIFFERENTIATION; DENDRITIC CELLS; GENES, IMMUNOGLOBULIN; GERM CELLS; HUMAN; LYMPHOID TISSUE; MUTATION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0028182886     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/j.1600-065X.1994.tb00664.x     Document Type: Article

References (39)

1. Antigens in Immunity, V: The Ability of Cells in Lymphoid Follicles to Recognize Foreignness
2. Timing, genetic requirements and functional consequences of somatic hypermutation during B cell development
3. Maturation of the immune response in germinal centres
4. Intraclonal generation of antibody mutants in germinal centres
5. In situ studies of the primary immune response to (4‐hydroxy‐3‐nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations
6. In situ studies of the primary immune response to (4‐hydroxy‐3‐nitrophenyl)acetyl. II. A common clonal origin for PALS‐associated foci and germinal centers
7. In situ studies of the primary immune response to (4‐hydroxy‐3‐nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells
8. Stable expression and somatic hypermutation of antibody V regions in B‐cell developmental pathways
9. The de novo generation of germinal centers is an oligoclonal process
10. + B cells from antibody‐secreting and memory B cell pathways in the C57BL/6 immune response to NP
11. Primary antibody‐forming cells and secondary B cells are generated from separate precursor cell subpopulations
12. Tolerance susceptibility of newly generating memory B cells
13. Among naive precursor cell subpopulations only progenitors of memory B cells originate germinal centers
14. The evolution of B‐cell clones
15. Molecular characterisation of single memory B cells
16. Antigen‐driven B cell differentiation in vivo
17. Inherited immunoglobulin idiotypes of the mouse
18. The follicular dendritic cell: Long term antigen retention during immunity
19. Antigens in Immunity, VI: The Phagocytic Reticulum of Lymph Node Follicles
20. Antigens in Immunity. Antigen Localization in Congenitally Athymic “Nude” Mice
21. De novo germinal center formation
22. Functional anatomy of germinal centers
23. The molecular and cellular basis of affinity maturation in the antibody response
24. Immunological tolerance: A second chance for bad B cells
25. Antigens in Immunity, XIV: Electron Microscopic‐Autoradiographic Studies of Antigen Capture in the Lymph Node Medulla
26. Antigens in Immunity, XV: Ultrastructural Features of Antigen Capture in Primary and Secondary Lymphoid Follicles
27. 131I‐Labelled Flagella in Lymph Nodes
28. Antigens in Immunity, VII: Analysis of Immunological Memory
29. 125I‐Labelled Antigens in the Secondary Response
30. Soluble antigen profoundly reduces memory B‐cell numbers even when given after challenge immunization
31. Anamnestic responses induced by antigen persisting on follicular dendritic cells from cyclophosphamide‐treated mice
32. A form of immunologic tolerance through impairment of germinal center development
33. Analysis of the repertoire of anti‐NP antibodies in C57BL/6 mice by cell fusion. I. Characterization of antibody families in the primary and hyperimmune response
34. Microanatomy of lymphoid tissue during humoral immune responses
35. The maintenance and regulation of the humoral immune response: persisting antigen and the role of follicular antigen‐binding dendritic cells as accessory cells
36. Persistence of memory B cells in mice deprived of T cell help
37. Accumulation of somatic mutants in the B cell compartment after primary immunization with a T cell‐dependent antigen
38. Ontogeny of the Immune Response, I: The Development of the Follicular Antigen‐Trapping Mechanism