Altered cortisol response and hippocampal atrophy in pediatric HIV disease

Journal of Acquired Immune Deficiency Syndromes

Volumn 7, Issue 1, 1994, Pages 57-62

  Oberfield, Sharon E ^a   Cowan, Linda ^a   Levine, Lenore S ^a   George, Ajax ^a   David, Raphael ^a   Litt, Andrew ^a   Rojas, Veronica ^a   Kairam, Ram ^a  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Central nervous system damage; Children; Cortisol secretion; Glucocorticoids; Hippocampus; HIV infection; Toxicity

Indexed keywords

HYDROCORTISONE;

ADOLESCENT; ARTICLE; BRAIN ATROPHY; CENTRAL NERVOUS SYSTEM DISEASE; CHILD; CHILDHOOD DISEASE; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CORTICOTROPIN TEST; FEMALE; HIPPOCAMPUS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYDROCORTISONE BLOOD LEVEL; HYDROCORTISONE RELEASE; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; INFANT; MALE; NEUROLOGIC DISEASE; NEURORADIOLOGY; PRIORITY JOURNAL;

ADOLESCENT; ADRENAL CORTEX FUNCTION TESTS; ATROPHY; CHILD; CHILD, PRESCHOOL; CORTICOSTERONE; CORTICOTROPIN; DESOXYCORTICOSTERONE; FEMALE; HIPPOCAMPUS; HIV INFECTIONS; HUMAN; HYDROCORTISONE; INFANT; MALE; NEUROLOGIC EXAMINATION; TOMOGRAPHY, X-RAY COMPUTED;

EID: 0028181509     PISSN: 15254135     EISSN: 10779450     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Morrill JE, Chen ISY. HIV-1, macrophages, glial cells, and cytokines in AIDS nervous system disease. FASEB 1991;5:2391-7.
2. Jacobson L, Sapolsky R. The role of the hippocampus in feedback regulation of the hypothalamic-pituitary-adrenocortical axis. Endocr Rev. 1991;2:118-34.
3. Sapolsky RM, Plotsky PM. Hypercortisolism and its possible neural basis. Biol Psychiatry 1990;27:937-52.
4. Sapolsky RM, Krey LC, McEwen BS. The neuroendocrinology of stress and aging: the glucocorticoid cascade hypothesis. Endocr Rev 1986;7:284-301.
5. Young EA, Akana S, Dallman MR. Decreased sensitivity to glucocorticoid fast feedback in chronically stressed rats. Neuroendocrinology 1990;51:536-42.
6. Young EA, Haskett RF, Murphy-Weinberg V, Watson ST, Akil H. Loss of glucocorticoid fast feedback in depression. Arch Gen Psychiatry 1991;48:693-9.
7. Starkman MN, Gebarski S, Berent S, Schteingart DE. Hippocampal formation volume, memory dysfunction and cor-tisol levels in patients with Cushing’s syndrome. Biol Psychiatry 1992;32:756-65.
8. DeLeon MJ, George AE, Stylopoulos L, Smith G, Miller DC. Early marker for Alzheimer’s disease: the atrophic hippocampus. Lancet 1989;ii:672-3.
9. DeLeon M, McRae T, Tsai JR, et al. Abnormal Cortisol response in Alzheimer’s disease linked to hippocampal atrophy. Lancet 1988;ii:391-2.
10. Oberfield SE, Kairam R, Bakshi S, et al. Steroid response to adrenocorticotropin stimulation in children with human immunodeficiency virus infection. J Clin Endocrinol Metab 1990;70:578-81.
11. Sapolsky RR, Pulsinelli W. Glucocorticoids potentiate ischemie injury to neurons: therapeutic implications. Science 1985;229:1397-400.
12. McEwen BS, Gould E, Sakai R. The vulnerability of the hippocampus to protective and destructive effects of glucocorticoids in relation to stress. Br J Psych 1992;160:18-24.
13. Uno H, Tarara R, Else JG, Suleman MA, Sapolsky RM. Hippocampal damage associated with prolonged and fatal stress in primates. J Neurol Sci 1989;9:1705-11.
14. Rosenfeld P, Sutanto WS, Levine S, DeKloet ER. Ontogeny of type I and type II corticosteroid receptors in the rat hippocampus. Dev Brain Res 1988;42:113-8.
15. Van Eekelen JAM, Jiang W, DeKloet ER, Bohn MC. Distribution of the mineralocorticoid and the glucocorticoid receptor mRNA’s in the rat hippocampus. J Neurosci Res 1988;21:88-94.
16. Edwards CRW, Stewart PM, Burt D, et al. Localization of 11β-hydroxysteroid dehydrogenase-tissue specific protector of the mineralocorticoid receptor. Lancet 1988;ii:986-9.
17. Moisan MP, Seckl JR, Edwards CRW. 11β-Hydroxysteroid dehydrogenase bioactivity and messenger RNA expression in rat forebrain: localization in hypothalamus, hippocampus and cortex. Endocrinology 1990;127:1450-5.
18. Sapolsky RM, Krey LC, McEwen BS. Glucocorticoidsensitive hippocampal neurons are involved in terminating the adrenocortical stress response. Proc Natl Acad Sci USA 1984;81:6174-7.
19. Sapolsky RM, Krey LC, McEwen BS. Prolonged glucocorticoid exposure reduces hippocampal neuron number: implications for aging. J Neurosci 1985;5:1222-7.
20. Peiffer A, Barden N, Meany MJ. Age related changes in glucocorticoid receptor binding and mRNA levels in the rat brain and pituitary. Neurobiol Aging 1991;12:475-9.
21. Jack C, Bentley M, Twomey M, Zinsmeister A. MR imaging based volume measurements of the hippocampal formation and anterior temporal lobe: validation studies. Radiology 1990;176:205-9.
22. Membrano L, Irony L, Dere W, Klein R, Biglieri E, Cobb C. Adrenocortical function in acquired immunodeficiency syndrome. J Clin Endocrinol Metab 1987;65:482-7.
23. Guilian D, Vaca K, Noona CA. Secretion of neurotoxins by mononuclear phagocytes infected with HIV-1. Science 1990;250:1593-6.