NF-kB and IkBα: An inducible regulatory system in endothelial activation

Journal of Experimental Medicine

Volumn 179, Issue 2, 1994, Pages 503-512

  Read, Margaret A ^a   Whitley, Maryann Z ^a   Williams, Amy J ^a   Collins, Tucker ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GROWTH HORMONE RECEPTOR; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ANTIGEN BINDING; ARTICLE; ELECTROPHORETIC MOBILITY; ENDOTHELIUM CELL; GENE EXPRESSION; GENE INDUCTION; GENE STRUCTURE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOBLOTTING; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROMOTER REGION; PROTO ONCOGENE; RECEPTOR UPREGULATION; REGULATORY MECHANISM; REPORTER GENE; RNA TRANSCRIPTION; STEADY STATE; TRANSCRIPTION INITIATION;

ANIMAL; BASE SEQUENCE; BLOTTING, WESTERN; CELL ADHESION MOLECULES; CELLS, CULTURED; CYTOKINES; DNA; DNA-BINDING PROTEINS; E-SELECTIN; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION; HUMAN; MOLECULAR SEQUENCE DATA; NF-KAPPA B; PROTEIN BINDING; RECOMBINANT PROTEINS; RNA, MESSENGER; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; SWINE; TUMOR NECROSIS FACTOR;

EID: 0028179224     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.179.2.503     Document Type: Article

References (47)

1. Fober, J.S., and R.C. Cotran. 1990. Cytokines and endothelial cell biology. Physiol. Rev. 70:427.
2. Neish, A.S., A.J. Williams, H.J. Palmer, M.Z. Whitley, and T. Collins. 1992. Functional analysis of the human vascular cell adhesion molecule 1 promoter. J. Exp. Med. 176:1583.
3. Iademarco, M.F., J.J. McQuillan, G.D. Rosen, and D.C. Dean. 1992. Characterization of the promoter for vascular cell adhesion molecule-1 (VCAM-1). J. Biol. Chem. 267:16323.
4. Whelan, J., P. Ghersa, R. Hooft van Huijsduijnen, J. Gray, G. Chandra, F. Talabot, and J.F. Delamarter. 1991. An NFkB-like factor is essential but not sufficient for cytokine induction of endothelial adhesion molecule 1 (ELAM-1) gene transcription. Nucleic Acids. Res. 19:2645.
5. Montgomery, K.F., L. Osborn, C. Hession, R. Tizard, D. Goff, C. Vassallo, P.I. Tarr, K. Bomsztyk, R. Lobb, J.M. Harlan, and T.H. Pohlman. 1991. Activation of endothelial-leukocyte adhesion molecule 1 (ELAM-1) gene transcription. Proc Natl. Acad. Sci. USA. 88:6523.
6. Mackman, N., K. Brand, and T.S. Edging ton. 1991. Lipopoly-saccharide-mediated transcriptional activation of the human tissue factor gene in THP-1 monocytic cells requires both activator protein 1 and nuclear factor kB binding sites.J. Exp Med. 174:1517.
7. Clark, B.D., K.L. Collins, M.S. Gandy, A.C. Webb, and P.E. Auron. 1986. Genomic sequence for human prointerleukin 1 beta: possible evolution from a reverse transcribed prointerleukin 1 alpha gene. Nucleic Acids Res. 20:7877.
8. Nakayama, K., H. Shimizu, K. Mitomo, T. Watanabe, S.I. Okamoto, and K.I. Yamamoto. 1992. A lymphoid cell-specific nuclear factor containing c-rel-like proteins preferentially interacts with interleukin-6 tcB-related motifs whose activities are repressed in lymphoid cells. Mol. Cell Biol. 12:1736.
9. Nishizawa, M., and S. Nagata. 1990. Regulatory elements responsible for inducible expression of the granulocyte colony-stimulating factor gene in macrophages. Mol. Cell Biol 10:2002.
10. Mukaida, N., Y. Mahe, and J. Matsushima. 1990. Cooperative interaction of nuclear factor-/B- and ris-regulatory enhancer protein-like protein-like factor binding elements in activating the interleukin-8 gene by pro-inflammatory cytokines. J. Biol. Chem. 265:21128.
11. Duyao, M.P., A.J. Buckler, and G.E. Sonenshein. 1990. Interaction of an NF-KB-like factor with a site upstream of the c-myc promoter. Proc Natl. Acad. Sci. USA. 87:4727.
12. Grimm, S., and RA. Baeuerle. 1993. The inducible transcription factor NF-kB: structure-function relationship of its protein subunits. Biochem. J. 290:297.
13. Blank, V., P. Kourilsky, and A. Israel. 1992. NF-kB and related proteins: rel/dorsal homologies meet ankyrin-like repeats. Trends Biochem. Sci. 17:135.
14. Baeuerle, P.A. 1991. The inducible transcription activator NF-kB: regulation by distinct protein subunits. Biochim. Biophy. Acta. 1072:63.
15. Liou, H.-C., and D. Baltimore. 1993. Regulation of the NF-fcB/rel transcription factor and IicB inhibitor system. Cum Opin. Cell Biol. 5:477.
16. Beg, A.A., S.M. Ruben, R.I. Scheinman, S. Haskill, C.A. Rosen, and A.S. Baldwin, Jr. 1992. IkB interacts with the nuclear localization sequences of the subunits of NF-kB: a mechanism for cytoplasmic retention. Genes & Dev. 6:1899.
17. Ganchi, P.A., S.C. Sun, W.C. Greene, and D.W. Ballard. 1992. IkB/MAD-3 masks the nuclear localization signal of NF-kB p65 and requires the transactivation domain to inhibit NF-kB p65 DNA binding. Mol. Biol. Cell. 3:1339.
18. Cordle, S.R., R. Donald, M.A. Read, andJ.J. Hawiger. 1993. Lipopolysaccharide induces phosphorylation of MAD3 and activation of c-REL and related NF-kB proteins in human monocytic THP-1 cells. J. Biol. Chem. 268:11810.
19. Beg, A.A., T.S. Finco, P.V. Nantermet, and A.S. Bladwin, Jr. 1993. Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of IkB-oí: a mechanism for NF-kB activation. Mol. Cell. Biol. 13:3301.
20. Collins, T., H.J. Palmer, M.Z. Whitley, A.S. Neish, and A.J. Williams. 1993. A common theme in endothelial activation. Insights from the structural analysis of the genes for E-selectin and VCAM-1. Trends in Cardiovascular Medicine. 3:92.
21. Read, M.A., S.R. Cordle, R.A. Veach, C.D. Carlisle, and J. Hawiger. 1993. Cell-free pool of CD14 mediates activation of NF-kB by lipopolysaccharide in human endothelial cells. Proc Natl. Acad. Sci. USA. 90:9887.
22. Gimbrone, M.A., Jr. 1976. Culture of vascular endothelium. In Progress in Hemostasis and Thrombosis. Vol. 3. T.H. Spaet, editor. Gruñe & Stratton, Inc., New York. 1-28.
23. Sambrook, J., E.F. Fritsch, and T. Maniatis. 1989. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY. 7.19-7.22.
24. Ausubel, F.M., R. Brent, R.E. Kingston, D.D. Moore, J.G. Seidman, J.A. Smith, and K. Struhl. 1989. In Current Protocols in Molecular Biology. Vol. 2. John Wiley & Sons, Inc., New York. 12.2.6.
25. Molitor, J.A., W.H. Walker, S. Doerre, D.W. Ballard, and W.C. Greene. 1990. NF-kB: a family of inducible and differentially expressed enhancer-binding proteins in human T cells. Proc Natl. Acad. Sci. USA. 87:10028.
26. Bradford, M.M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248.
27. Ballard, D.W., E.P. Dixon, N.J. Peffer, H. Bogerd, S. Doerre, B. Stein, and W.C. Greene. 1992. The 65-kDa subunit of human NF-kB functions as a potent transcriptional activator and a target for v-Rel-mediated repression. Proc Natl. Acad. Sci. USA. 89:1875.
28. Haskill, S., A.A. Beg, S.M. Tompkins, J.S. Morris, A.D. Yurochko, A. Sampson-Johannes, K. Mondai, P. Ralph, and A.S. Baldwin, Jr. 1991. Characterization of an immediate-early gene induced in adherent monocytes that encodes IkB activity. Cell. 65:1281.
29. Ballard, D.W., W.H. Walker, S. Doerre, P. Sista, J.A. Molitor, E.P. Dixon, N.J. Peffer, M. Hannink, and W.C. Greene. 1990. The v-rel oncogene encodes a kB enhancer binding protein that inhibits NF-kB function. Cell. 63:803.
30. Collins, T., A. Williams, G.I. Johnson, J. Kim, R. Eddy, T. Shows, M.A. Gimbrone, Jr., and M. P. Bevilaqua. 1991. Structure and chromosomal location of the gene for endothelial-leukocyte adhesion molecule 1. J. Biol. Chem. 266:2466.
31. Sasahara, M., J.W.U. Fries, E.W. Raines, A.M. Gown, L.E. Westrum, M.P. Frosch, D.T. Bonthron, R. Ross, and T. Collins. 1991. PDGF B-chain in neurons of the central nervous system, posterior pituitary, and in a transgenic model. Cell. 64:217.
32. Nolan, G.P., S. Ghosh, H.C. Liou, P. Tempst, and D. Baltimore. 1991. DNA binding and IkB inhibition of the cloned p65 subunit of NF-kB, a β-related peptide. Cell. 64:961.
33. Ghosh, S., A.M. Gifford, L.R. Riviere, P. Tempst, G.P. Nolan, and D. Baltimore. 1990. Cloning of the p50 DNA binding subunit of NF-kB: homology to rel and dorsal. Cell. 62:1019.
34. Bours, V., J. Villalobos, P.R. Burd, K. Kelly, and U. Siebenlist. 1990. Cloning of a mitogen-inducible gene encoding a kB DNA-binding protein with homology to the rel oncogene and to cell-cycle motifs. Nature (Lond.). 348:76.
35. Brownell, E., N. Mittereder, and N.R. Rice. 1989. A human rel proto-oncogene cDNA containing an Alu fragment as a potential coding exon. Oncogene. 4:935.
36. Larigan, J.D., T.C. Tsang, J.M. Rumberger, and D.K. Bums. 1992. Characterization of cDNA and genomic sequences encoding rabbit ELAM-1: conservation of structure and functional interactions with leukocytes. DNA Cell Biol. 11:149.
37. Kunsch, C., S.M. Ruben, and C.A. Rosen. 1992. Selection of optimal xB/rel DNA-binding motifs: interaction of both subunits of NF-kB with DNA is required for transcriptional activation. Mol. Cell. Biol. 12:4412.
38. Becker-André, M., R.H. Van Huijsduijnen, C. Losberger, J. Whelan, and J.F. Delamarter. 1992. Murine endothelial leukocyte-adhesion molecule 1 is a close structural and functional homologue of the human protein. Eur. J. Biochem. 206: 401.
39. Shi, H.B., A. Agranoff, E.G. Nabel, K. Leung, A.S. Neish, T. Collins, and G. Nabel. 1993. Differential regulation of vascular cell adhesion molecule 1 gene expression by specific NF-kB subunits in endothelial and epithelial cells. Mol. Cell. Biol. 13:6283.
40. Mackay, F., H. Loetscher, D. Stueber, G. Gehr, and W. Lesslauer. 1993. Tumor necrosis factor a (TNF-a)-induced cell adhesion to human endothelial cells is under dominant control of one TNF receptor type, TNF-R55. J. Exp Med. 177:1277.
41. Schutze, S., K. Potthoff, T. Machleidt, D. Berkovic, K. Wiegmann, and M. Kronke. 1992. TNF activates NF-kB by phosphatidylcholine-specific phospholipase C-induced “acidic” sphingomyelin breakdown. Cell. 71:765.
42. Martin, R., B. Vanhove, Q. Cheng, E. Hofer, V. Csizmadia, H. Winkler, and F.H. Bach. 1993. Cytokine-inducible expression in endothelial cells of an IxBa-like gene is regulated by NF-kB. EMBO (Ear. Mol. Biol. Organ.) J. 12:2773.
43. Sun, S.C., RA. Ganchi, D.W. Ballard, and W.C. Greene. 1993. NF-kB controls expression of inhibitor I/cB-a: evidence for an inducible autoregulatory pathway. Science (Wash. DC). 259:1912.
44. Brown, K., S. Park, T. Kanno, G. Franzoso, and U. Siebenlist. 1993. Mutual regulation of the transcriptional activator NF-kB and its inhibitor, IkB-ck. Proc Natl. Acad. Sci. USA. 90:2532.
45. Scott, M.L., T. Fujita, H.-C. Liou, G.P. Nolan, and D. Baltimore. 1993. The p65 subunit of NF-#cB regulates IkB by two distinct mechanisms. Genes & Dev. 7:1266.
46. Schreck, R., and P. Baeuerle. 1992. A role for oxygen radicals as second messengers. Trends Cell Biol. 1:39.
47. Collins, T. 1993. Endothelial nuclear factor-kB and the initiation of the atherosclerotic lesion. Lah Invest. 68:499.