TGF‐β receptor regulation mediates the response to exogenous ligand but is independent of the degree of cellular differentiation in human oral keratinocytes

International Journal of Cancer

Volumn 56, Issue 3, 1994, Pages 406-412

  Prime, S S ^a   Matthews, J B ^b   Patel, V ^a   Game, S M ^a   Donnelly, M ^a   Stone, A ^a   Paterson, I C ^a   Sandy, J R ^a   Yeudall, W A ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR RECEPTOR; KERATIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; AUTOCRINE EFFECT; CELL DIFFERENTIATION; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; KERATINOCYTE; LIGAND BINDING; MOUTH CANCER; PRIORITY JOURNAL;

3T3 CELLS; ANIMAL; CARCINOMA, SQUAMOUS CELL; CELL DIFFERENTIATION; CELL LINE; CULTURE MEDIA, CONDITIONED; HUMAN; KERATIN; KERATINOCYTES; MICE; MOUTH MUCOSA; MOUTH NEOPLASMS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SUPPORT, NON-U.S. GOV'T; TRANSFORMING GROWTH FACTOR BETA; TUMOR CELLS, CULTURED; VIMENTIN;

EID: 0028179164     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.2910560320     Document Type: Article

References (24)

1. Growth stimulation of human breast cancer cells with anti‐transforming growth factor‐β antibodies: evidence for negative autocrine regulation by transforming growth factor‐β
2. Inactiyation of the type II receptor reveals two receptor pathways for the diverse TGF‐β activities
3. Autocrine production of TGF‐α and TGF‐β during tumour progression of rat oral keratinocytes
4. Cloning of a type I receptor and its effect on TGF‐β binding to the type II receptor
5. Role of the latent TGF‐β binding protein in the activation of latent TGF‐β by co‐cultures of endothelial and smooth muscle cells
6. Progressive abrogation of TGF‐β1 and EGF growth control is associated with tumour progression in ras‐transfected human keratinocytes
7. Differentiation of malignant oral rat keratinocytes reflects changes in EGF and TGF‐β receptor expression but not growth factor dependence
8. Lack of correlation between sensitivity to growth inhibition and receptor number for transforming growth factor p in human squamous carcinoma cell lines
9. Biological effects and binding properties of transforming growth factor‐β on human oral squamous‐cell carcinoma cells
10. Responsiveness to transforming growth factor‐β (TGF‐β) restored by genetic complementation between cells defective in TGF‐β receptors I and II
11. Concomitant loss of transforming growth factor (TGF)‐β receptor types I and II in TGF‐β‐resistant cell mutants implicates both receptor types in signal transduction
12. Expression cloning of the TGF‐β type II receptor, a functional transmembrane serine/threonine kinase
13. Betaglycan presents ligand to the TGF‐β signalling receptor
14. Escape from transforming growth factor β control and oncogene cooperation in skin tumour development
15. Cytoplasmic markers of disturbed epithelial differentiation as markers of high‐risk lesions with special reference to cytokeratins
16. The culture of primary tumours from human epidermis
17. Consistent chromosomal anomalies in keratinocyte cell lines derived from untreated malignant lesions of the oral cavity
18. The behaviour of human oral squamous cell carcinoma in cell culture
19. High frequency of resistance of human squamous carcinoma cells to the anti‐proliferative action of transforming growth factor‐p
20. Binding of transforming growth factor‐β to cell surface proteins varies with cell type
21. Decreased integrin expression is correlated with reduced capacity for terminal differentiation in cell lines derived from oral squamous cell carcinomas
22. Particular types of tumour cells have the capacity to convert transforming growth factor β from a latent to an active form
23. TGF‐β signals through a heteromeric protein kinase receptor complex
24. 2 in quiescent CBS colon carcinoma cells leads to progression of tumorigenic properties