Cefdinir (CI-983), a new oral amino-2-thiazolyl cephalosporin, inhibits human neutrophil myeloperoxidase in the extracellular medium but not the phagolysosome

Journal of Immunology

Volumn 152, Issue 5, 1994, Pages 2447-2455

  Labro, M Thérèse ^a   El Benna, Jamel ^a   Charlier, Natacha ^b   Abdelghaffar, Houria ^a   Hakim, Jacques ^a  

^a BICHAT HOSPITAL   (France)

^b HÔPITAL DU BOCAGE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GLUCURONIDASE; CALCIUM IONOPHORE; CEFDINIR; CEFIXIME; CEFODIZIME; CEFTAZIDIME; CEFTIZOXIME; CEFTRIAXONE; CEFUROXIME; FORMYLMETHIONYLLEUCYLPHENYLALANINE; ZYMOSAN;

ARTICLE; BACTERICIDAL ACTIVITY; CELL FREE SYSTEM; CHEMOLUMINESCENCE; CONCENTRATION RESPONSE; DEGRANULATION; ENZYME INHIBITION; ENZYME RELEASE; HUMAN; HUMAN CELL; IMMUNOMODULATION; PHAGOCYTOSIS; PRIORITY JOURNAL; RESPIRATORY BURST;

BLOOD BACTERICIDAL ACTIVITY; CALCIMYCIN; CELL DEGRANULATION; CEPHALOSPORINS; CYTOCHALASIN B; EXTRACELLULAR SPACE; HUMANS; HYDROGEN PEROXIDE; LUMINESCENT MEASUREMENTS; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NEUTROPHILS; PEROXIDASE; PHAGOSOMES; TETRADECANOYLPHORBOL ACETATE; ZYMOSAN;

EID: 0028178305     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (65)

1. Borregaard, N. 1988. The human neutrophil function and dysfunction. Eur. J. Haematol. 41:401.
2. Cochrane, C. G., R. G. Spragg, S. D. Revak, A. B. Cohen, and W. W. McGuire. 1983. The presence of neutrophil elastase and evidence of oxidation activity in bronchoalveolar lavage fluid of patients with adult respiratory distress syndrome. Am. Rev. Respir. Dis. 127:525.
3. Rothe, G., W. Kellermann, and G. Valet. 1990. Flow cytometric parameters of neutrophil function as early indicators of sepsis- or trauma-related pulmonary or cardiovascular organ failure. J. Lab. Clin. Med. 115:52.
4. Babior, B. M. 1978. Oxygen-dependent microbial killing by phagocytes. N. Engl. J. Med. 298:659.
5. Babior, B. M. 1984. Oxidants from phagocytes: agents of defense and destruction. Blood 64:959.
6. Baird, B. R., J. C. Cheronis, R. A. Sandhaus, E. M. Berger, C. W. White, and J. E. Repine. 1986. Oxygen metabolites and neutrophil elastase synergistically cause edematous injury in isolated rat lungs. J. Appl. Physiol. 61:2224.
7. Brigham, K. L. 1991, Oxygen-radicals an important mediator of sepsis and septic shock. Klin. Wochenschr. 69:1001.
8. Roos, D. 1991. The involvement of oxygen radicals in microbicidal mechanisms of leukocytes and macrophages. Klin. Wochenschr. 69: 975.
9. Welch, W. D., D. Davis, and L. D. Thrupp. 1981. Effect of antimicrobial agents on human polymorphonuclear leukocyte microbicidal function. Antimicrob. Agents Chemother. 20:15.
10. Repine, J. E., and C. J. Beehler. 1991. Neutrophils and adult respiratory distress syndrome: two interlocking perspectives in 1991. Am. Rev. Respir. Dis. 144:251.
11. Labro, M. T., and J. El Benna. 1991. Effects of antiinfectious agents on polymorphonuclear neutrophils. Eur. J. Clin. Microbiol. Infect. Dis. 10:124.
12. Van den Broek, P. S. 1989. Antimicrobial drugs, microorganisms and phagocytes. Rev. Infect. Dis. 11:213.
13. Duncker, D., and U. Ullmann. 1986. Influence of various antimicrobial agents on the chemiluminescence response of phagocytosing human granulocytes. Chemotherapy 32:18.
14. Ono, Y., and K. Otohiko. 1989. Influence of forty-two antimicrobial agents on the chemiluminescence response of human phagocytic cells. Chemotherapy (Tokyo) 37:583.
15. Labro, M. T., C. Babin-Chevaye, and J. Hakim. 1986. Effects of Cefotaxime and Cefodizime on human granulocyte functions in vitro. J. Antimicrob. Chemother. 18:233.
16. Labro, M. T., N. Amit, C. Babin-Chevaye, and J. Hakim. 1987. Cefodizime (HR221) potentiation of human neutrophil oxygen-independent bactericidal activity. J. Antimicrob. Chemother. 19:331.
17. Ohnishi, H., H. Inaba, H. Mochizuki, and H. Kosuzume. 1984. Mechanism of action of AC 1370 on phagocyte functions. Antimicrob. Agents Chemother. 25:88.
18. Ohnishi, U., H. Kosuzume, H. Inaba, M. Okura, H. Mochizuki, Y. Suzuki, and R. Fujii. 1983. Effects of AC1370 on phagocyte functions. Antimicrob. Agents Chemother. 23:874.
19. Rodriguez, A. B., A. Hernanz, and M. de la Fuente. 1991. Effect of three β-lactam antibiotics on ascorbate content, phagocytic activity and superoxide anion production in human neutrophils. Cell. Physiol. Biochem. 1:170.
20. Briheim, G., and C. Dahlgren. 1987. Influence of antibiotics on formylmethionyl-leucyl-phenylalanine-induced leukocyte chemiluminescence. Antimicrob. Agents Chemother. 31:763.
21. Ottonello, L., F. Dallegri, P. Dapino, G. Pastorino, and C. Sacchetti. 1991. Cytoprotection against neutrophil-delivered oxidant attack by antibiotics. Biochem. Pharmacol. 42:2317.
22. Gunther, M. R., J. Mao, and M. S. Cohen. 1993. Oxidant scavenging activities of ampicillin and sublactam and their effects on neutrophil functions. Antimicrob. Agents Chemother. 37:950.
23. Gemmel, C. G. 1984. Potentiation of phagocytosis of pathogenic bacteria by exposure to low concentrations of antibiotics. J. Antimicrob. Chemother. 13:407.
24. Labro, M. T., and J. El Benna. 1990. Comparison of Cefodizime with various cephalosporins for their indirect effect on the human neutrophil oxidative burst in vitro. J. Antimicrob. Chemother. 26(Suppl. C):49.
25. Labro, M. T., C. Babin-Chevaye, and J. Hakim. 1988. Influence of subinhibitory concentration of Ceftriaxone on opsonization and killing of P. aeruginosa by human neutrophils. J. Antimicrob. Chemother. 22:341.
26. Labro, M. T., and J. El Benna. 1991. Effect of monodesethyl amodiaquine on human polymorphonuclear neutrophil function in vitro. Antimicrob. Agents Chemother. 35:824.
27. Cohen, H. J., and M. E. Chovaniec. 1978. Superoxide generation by digitonin-stimulated guinea-pig granulocytes. J. Clin. Invest. 61:1081.
28. Hakim, J., E. Cramer, P. Boivin, H. Troube, and J. Boucherot. 1975. Quantitative iodination of human blood polymorphonuclear leukocytes. Eur. J. Clin. Invest. 5:215.
29. Bates, E. J., and A. Ferrante. 1988. Stimulation of human neutrophil degranulation by mefloquine. Int. Arch. Allergy Appl. Immunol. 86: 446.
30. Fontagne, J., M. Roch-Arweiller, J. P. Giroud, and P. Lechat. 1989. Effects of some antimalarial drugs on rat inflammatory polymorphonuclear leukocyte function. Biomed. Pharmacother. 43:43.
31. Roder, B. L., A. Forsgren, and E. Gutschick. 1991. The effect of antistaphylococcal agents used alone and in combinations on the survival of Staphylococcus aureus ingested by human polymorphonuclear leukocytes. Acta Pathol. Microbiol. Immunol. Scand. 99: 521.
32. de Chatelet, L. R., G. D. Long, P. S. Shirley, D. A. Bass, M. J. Thomas, F. W. Henderson, and M. S. Cohen. 1982. Mechanism of the luminol-dependent chemiluminescence of human neutrophils. J. Immunol. 129:1589.
33. Gullenhammar, H. 1987. Lucigenin chemiluminescence in the assessment of neutrophil superoxide production. J. Immunol. Methods 97:209.
34. Forrest, C. B., J. R. Forehand, R. A. Axtell, R. L. Roberts, and R. B. Johnston, Jr. 1988. Clinical features and current management of chronic granulomatous diseases. Hematol. Oncol. Clin. N. Am. 2:253.
35. 2-Cl- system of neutrophils by indomethacin and other non-steroidal anti-inflammatory drugs. Biochem. Pharmacol. 41:975.
36. Zurbier, K. W. M., A. R. J. Bakkenist, R. H. Fokkens, N. M. M. Nibbering, R. Wever, and A. O. Muijsers. 1990. Interaction of myeloperoxidase with diclofenac. Biochem. Pharmacol. 40:1801.
37. Grant, M., J. A. Raeburn, R. Sutherland, R. A. Harkness, I. P. Gormley, and M. J. Kowolik. 1983. Effect of two antibiotics on human granulocyte activities. J. Antimicrob. Chemolher. 11:543.
38. Van Zyl, J. M., K. Basson, R. A. Uebel, and B. J. Van der Walt. 1989. Isoniazid-mediated irreversible inhibition of the myeloperoxidase antimicrobial system of the human neutrophil and the effect of thyronins. Biochem. Pharmacol. 38:2363.
39. Shoeb, H. A., B. U. Bowman, Jr., A. C. Ottolenghi, and A. J. Merola. 1985. Peroxidase-mediated oxidation of isoniazid. Antimicrob. Agents Chemother. 27:399.
40. Shoeb, H. A., B. U. Bowman, Jr., A. C. Ottolenghi, and A. J. Merola. 1985. Evidence for the generation of active oxygen by isoniazid treatment of extracts of Mycobacterium tuberculosis H37Ra. Antimicrob. Agents Chemother. 27:404.
41. Anderson, R., A. D. Beyers, J. E. Savage, and A. E. Nel. 1988. Apparent involvement of phospholipase A2 but not protein kinase C in the pro-oxidative interactions of Clofazimine with human phagocytes. Biochem. Pharmacol. 37:3635.
42. Savage, J. E., J. F. O'Sullivan, B. M. Zeis, and R. Anderson. 1989. Investigation of the structural properties of dihydrophenazines which contribute to their pro-oxidative interaction with human phagocytes. J. Antimicrob. Chemother. 23:691.
43. Van Zyl, J. M., K. Basson, A. Kriegler, and B. J. Van der Walt. 1991. Mechanisms by which Clofazimine and dapsone inhibit the myeloperoxidase system. A possible correlation with their anti-inflammatory properties. Biochem. Pharmacol. 42:599.
44. Chuaprapaisilp, T., and T. Piamphongsant. 1978. Treatment of pustular psoriasis with Clofazimine. Br. J. Dermatol. 99:303.
45. Lang, P. G. 1979. Sulfones and sulfonamides in dermatology today. J. Am. Acad. Dermatol. 1:475.
46. Mackey, J. P., and J. Barnes. 1974. Clofazimine in the treatment of discoid lupus erythematosus. Br. J. Dermatol. 91:93.
47. Williams, K., R. B. Capstick, D. A. Lewis, and R. Best. 1976. Anti-inflammatory actions of dapsone and its related biochemistry. J. Pharm. Pharmacol. 28:55.
48. Yawalkar, S. J., and W. Vischer. 1979. Lamprene (Clofazimine) in leprosy. Leprosy Rev. 50:135.
49. Clark, R. A. 1990. The human neutrophil respiratory burst oxidase. J. Infect. Dis. 161:1140.
50. Root, R. K., and M. S. Cohen. 1981. Microbicidal mechanisms of phagocytic cells. Rev. Infect. Dis. 3:565.
51. Boxer, L. A., and J. E. Smolen. 1988. Neutrophil granule constituents and their release in health and disease. Hematol. Oncol. Clin. N. Am. 2:101.
52. Gabler, W. L., and H. R. Creamer. 1991. Suppression of human neutrophil functions by tetracyclines. J. Periodont. Res. 26:52.
53. Dalziel, K., P. J. Dykes, and R. Marks. 1987. The effect of tetracyclin and erythromycin in a model of acne-type inflammation. Br. J. Exp. Pathol. 68:67.
54. Anderson, R. 1989. Erythromycin and roxithromycin potentiate human neutrophil locomotion in vitro by inhibition of leukoattractant activated superoxide generation and autooxidation. J. Infect. Dis. 159:966.
55. Hand, W. L., D. L. Hand, and N. L. King-Thompson. 1990. Antibiotic inhibition of the respiratory burst response in human polymorphonuclear leukocytes. Antimicrob. Agents. Chemother. 34:863.
56. Labro, M. T., J. El Benna, and C. Babin-Chevaye. 1989. Comparison of the in vitro effect of several macrolides on the oxidative burst of human neutrophils. J. Antimicrob. Chemother. 24:561.
57. Plewig, G., and E. Schöpf. 1976. Antiinflammatory effects of antimicrobial agents. Drugs 11:472.
58. Siegel, J. P., and J. S. Remington. 1982. Effect of antimicrobial agents on chemiluminescence of human polymorphonuclear leukocytes in response to phagocytosis. J. Antimicrob. Chemother. 10: 505.
59. Oleske, J. M., A. de la Cruz, H. Ahdieh, D. Sorvino, J. La Braico, R. Cooper, R. Singh, R. Lin, and A. Minnefor. 1983. Effects of antibiotics on polymorphonuclear leukocyte chemiluminescence and chemotaxis. J. Antimicrob. Chemother. 12(Suppl. C):35.
60. Flanagan, M. D., and S. Lin. 1980. Cytochalasin block actin filament elongation by binding to high affinity sites associated with F-actin. J. Biol. Chem. 255:835.
61. Labro, M. T., J. El Benna, and A. Jemni. 1992. Synergy between Cefdinir (CI-983, FK-482) and human neutrophils for bactericidal activity in-vitro (Abstract 33). In Program and Abstracts of 10th Meeting of Future Trends in Chemotherapy. BioScience Ediprint, Geneva.
62. McDonald, P. J., H. Pruul, and K, Daley. 1992. Synergy of Cefdinir (CI-983, FK-482) with phagocytic killing systems: interactions of serum and neutrophils with Cefdinir-exposed Escherichia coli and Staphylococcus aureus (Abstract 61). In Program and Abstracts of the 17th International Congress of Chemotherapy. Futuramed Verlagsgesellschaft mbH, München.
63. Ahlstedt, S. 1981. The antibacterial effects of low concentration of antibiotics and host defence factors: a review. J. Antimicrob. Chemother. 8(Suppl. C):59.
64. Home, D., and A. Tomasz. 1981. Hypersusceptibility of penicillin-treated group B streptococci to bactericidal activity of human polymorphonuclear leukocytes. Antimicrob. Agents Chemother. 19:745.
65. Lorian, V. 1985. Low concentration of antibiotics. J. Antimicrob. Chemother. 15(Suppl. A):15.