Genotoxicity of the alkenylbenzenes α- and β-asarone, myristicin and elemicin as determined by the UDS assay in cultured rat hepatocytes

Food and Chemical Toxicology

Volumn 32, Issue 3, 1994, Pages 223-231

  Hasheminejad, G ^a   Caldwell, J ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ASARONE; BENZENE DERIVATIVE; BETA ASARONE; CIMETIDINE; ELEMICIN; MYRISTICIN; PENTACHLOROPHENOL;

ANIMAL CELL; ARTICLE; BIOTRANSFORMATION; CONTROLLED STUDY; GENOTOXICITY; LIVER CELL CULTURE; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; UNSCHEDULED DNA SYNTHESIS;

ALKYLATION; ANIMAL; ANISOLES; BIOTRANSFORMATION; CELLS, CULTURED; CIMETIDINE; DIOXOLANES; DNA; DNA DAMAGE; DNA REPAIR; LACTATE DEHYDROGENASE; LIVER; MALE; PENTACHLOROPHENOL; PYROGALLOL; RATS; RATS, INBRED F344; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T;

EID: 0028178150     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/0278-6915(94)90194-5     Document Type: Article

References (34)

1. Chemical quantification of UDS in cultured hepatocytes as assay for the rapid screening of potential chemical carcinogens
2. Chemical carcinogenesis: too many rodent carcinogens.
3. Metabolism of estragole in rat and mouse and influence of dose size on excretion of the proximate carcinogen 1'-hydroxyestragole
4. Comparative studies on the metabolism of food additives: case samples in the safety evaluation of the allylbenzene natural flavors
5. Comparative induction of unscheduled DNA synthesis in cultured rat hepatocytes by allylbenzenes and their 1'-hydroxy metabolites
6. Selective inhibition of rat hepatic microsomal cytochrome P450
7. The inhibition of DNA repair in UV-irradiated human cells
8. Stereoselectivity of the aliphatic hydroxylation of 6-n-propylchrome-2-carboxylic acid in rat and guinea pig
9. Report of a comparative study of DNA damage and repair assays in primary rat hepatocytes chemicals with five coded chemicals
10. The in vitro unscheduled DNA synthesis (UDS) assay in rat primary hepatocytes: validation of improved methods for primary culture including data in the lack of effect of ionizing radiation
11. Induction of unscheduled DNA synthesis in rat and hamster hepatocytes by cooked food mutagens
12. Structure-specificity of the genotoxicity of some naturally occurring alkenylbenzenes determined by the unscheduled DNA synthesis assay in rat hepatocytes
13. Use of scintillometric quantitation of unscheduled DNA synthesis in isolated rat hepatocytes for the screening of genotoxic agents
14. Trypan blue dye uptake and LDH leakage in adult rat hepatocyte—freshly isolated cells, cell suspensions and primary monolayer cultures
15. The fluorimetric measurement of deoxyribonucleic acid in animal tissues with special reference to the CNS
16. The validity of the autoradiographic method for detecting DNA repair synthesis in rat hepatocytes in primary culture
17. Influence of modulators of epoxide metabolism in the cytotoxicity of trans-anethole in freshly isolated rat hepatocytes
18. The cytotoxicity and genotoxicity of anethole 1,2-epoxide, a primary metabolite of the food flavour trans-anethole
19. Some current perspectives on chemical carcinogenesis in humans and experimental animals: Presidential Address
20. Structure-activity studies of the carcinogenicity in the mouse and rat of some naturally occurring and synthetic alkenylbenzene derivative related to safrole and estragole
21. A method for rapid, sensitive quantitation of short-patch DNA repair in cultured rat hepatocytes
22. Determinants of cytochrome P450 in liver cell culture
23. Chemically-induced UDS in primary rat hepatocyte cultures: a comparison with bacterial mutagenicity using 218 compounds
24. Mutagenicity and DNA-damaging activity of calamus oil, asarone isomers and dimethoxy propenyl benzene analogues
25. The dose-dependent disposition of anethole, estragole and p-propylanisole in relation to their safety evaluation
26. 14C]-labelled trans-anethole, estragole and p-propylanisole in human volunteers
27. Cytotoxicity and reduced glutathione (GSH) depletion by cinnamaldehyde in rat hepatocytes
28. Toxicity of Oil of Calamus (Jammu variety)
29. Mutagenicity of trans-anethole, estragole, eugenol and safrole in the Ames Salmonella typhimurium assay
30. The predictive value of rodent carcinogenicity tests in the evaluation of human risks
31. DNA repair tests in cultured mammalian cells
32. 1 mice
33. Principles for the Safety Assessment of Food Additives and Contaminants in Food