Redistribution of a rab3-like GTP-binding protein from secretory granules to the Golgi complex in pancreatic acinar cells during regulated exocytosis

Journal of Cell Biology

Volumn 124, Issue 1-2, 1994, Pages 43-53

  Jena, Bhanu P ^a   Gumkowski, Francine D ^a   Konieczko, Elisa M ^a   Von Mollard, Gabriele Fischer ^a   Jahn, Reinhard ^a   Jamieson, James D ^a,b  

^a YALE UNIVERSITY   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBACHOL; ENZYME PRECURSOR; GUANINE NUCLEOTIDE BINDING PROTEIN; MONOCLONAL ANTIBODY; RAS PROTEIN;

ACINAR CELL; ANIMAL CELL; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; ENZYME INDUCTION; EXOCYTOSIS; GOLGI COMPLEX; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN LOCALIZATION; PROTEIN TARGETING; RAT; SECRETORY GRANULE; SYNAPSE VESICLE;

ANIMALIA;

EID: 0028177963     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.124.1.43     Document Type: Article

References (35)

1. Amsterdam, A., T. E. Solomon, and J. D. Jamieson. 1978. Sequential dissociation of the exocrine pancreas into lobules, acini, and individual cells. Methods Cell Biol. 20:361-378.
2. Araki, S., A. Kikuchi, Y. Hata, M. Isoaura, and Y. Takai. 1990. Regulation of reversible binding of smgp25A, a ras p21-like GTP-binding protein, to synaptic plasma membranes and vesicles by its specific regulatory protein, GDP dissociation inhibitor. J. Biol. Chem. 265:13007-13015.
3. Arvan, P., and J. D. Castle. 1987. Phasic release of newly synthesized secretory proteins in the unstimulated rat exocrine pancreas. J. Cell Biol. 104: 243-252.
4. Balch, W. E. 1990. Small GTP-binding proteins in vesicular transport. Trends Biochem. Sci. 15:473-477.
5. Baldini, G., T. Hohl, H. Y. Lin, and H. F. Lodish. 1992. Cloning of a rab3 isotype predominantly expressed in adipocytes. Proc. Natl. Acad. Sci. USA. 89:5049-5052.
6. Burgess, T. L., and R. B. Kelly. 1987. Constitutive and regulated secretion of proteins. Annu. Rev. Cell Biol. 3:243-293.
7. Cameron, R. S., P. L. Cameron, and J. D. Castle. 1986. A common spectrum of polypeptides occurs in secretion granule membranes of different exocrine glands. J. Cell Biol. 103:1299-1313.
8. Chavrier, P., R. G. Parton, H. P. Hauri, K. Simons, and M. Zerial. 1990a. Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments. Cell. 62:317-329.
9. Chavrier, P., M. Vingron, C. Sander, K. Simon, and M. Zerial. 1990b. Molecular cloning of YPT1/SEC4-related cDNAs from an epithelial cell line. Mol. Cell. Biol. 10:6578-6585.
10. Cornell-Bell, A. H., L. R. Otake, K. Sadler, P. G. Thomas, S. Lawrence, K. Olsen, F. Gumkowski, J. R. Peterson, and J. D. Jamieson. 1993. Membrane glycolipid trafficking in living, polarized pancreatic acinar cells: assessment by confocal microscopy. Methods Cell Biol. 38:221-240.
11. DeCamilli, P., S. M. Harris, W. B. Huttner, and P. Greengard. 1983. Synapsin I (protein I), a nerve terminal specific phosphoprotein II. Its specific association with synaptic vesicles demonstrated by immunocytochemistry in agarose-embedded synaptosomes. J. Cell Biol. 96:1355-1373.
12. Fischer von Mollard, G., G. A. Mignery, M. Baumert, M. S. Perin, T. J. Hanson, P. M. Burger, R. Jahn, and T. C. Südhof. 1990. rab3 is a small GTP-binding protein exclusively localized to synaptic vesicles. Proc. Natl. Acad. Sci. USA. 87:1988-1992.
13. Fischer von Mollard, G., T. C. Südhof, and R. Jahn. 1991. A small GTP-binding protein dissociates from synaptic vesicles during exocytosis. Nature (Lond.). 349:79-81.
14. Gomperts, B. D. 1990. GE: A GTP-binding protein mediating exocytosis. Annu. Rev. Physiol. 52:591-606.
15. Hall, A. 1990. The cellular functions of small GTP-binding proteins. Science (Wash. DC). 249:635-640.
16. Jamieson, J. D., and G. E. Palade. 1971a. Condensing vacuole conversion and zymogen granule discharge in pancreatic exocrine cells: metabolic studies. J. Cell Biol. 48:503-522.
17. Jamieson, J. D., and G. E. Palade. 1971b. Synthesis, intracellular transport, and discharge of secretory proteins in stimulated pancreatic exocrine cells. J. Cell Biol. 50:135-158.
18. 2+-dependent amylase secretion from pancreatic acini. J. Biol. Chem. 266:17744-17746.
19. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond.). 227:680-685.
20. Lambert, M., N.-D. Bui, and J. Christophe. 1990. Novel GTP-binding proteins in plasma membranes and zymogen granule membranes from rat pancreas and in pancreatic AR 4-2J cell membranes. FEBS (Fed. Eur. Biochem. Soc.) Lett. 271:19-22.
21. Lapetina, E. G., and B. R. Reep. 1987. Specific binding of [α-32P]GTP to cytosolic and membrane-bound proteins of human platelets correlates with the activation of phospholipase C. Proc. Natl. Acad. Sci. USA. 84:2261-2265.
22. Matteoli, M., K. Takei, R. Cameron, P. Hurlbut, P. A. Johnston, T. C. Südhof, R. Jahn, and P. De Camilli. 1991. Association of Rab3A with synaptic vesicles at late stages of the secretory pathway. J. Cell Biol. 115:625-633.
23. Mizoguchi, A., S. Kim, T. Ueda, and Y. Takai. 1989. Tissue distribution of smg p25a, a ras p21-like GTP-binding protein, studied by use of a specific monoclonal antibody. Biochem. Biophys. Res. Commun. 162:1438-1445.
24. Novick, P., B. Goud, A. Salminen, N. C. Walworth, J. Nair, and M. Potenza. 1988. Regulation of vesicular traffic by a GTP-binding protein on the cytoplasmic surface of secretory vesicles in yeast. Cold Spring Harb. Symp. Quant. Biol. 53:637-647.
25. Padfield, P. J., and J. D. Jamieson. 1991. Low molecular weight GTP-binding proteins associated with zymogen granule membranes from rat pancreas. Biochem. Biophys. Res. Commun. 174:600-605.
26. Padfield, P. J., W. E. Balch, and J. D. Jamieson. 1992. A synthetic peptide of the rab3a effector domain stimulates amylase release from permeabilized pancreatic acini. Proc. Natl. Acad. Sci. USA. 89:1656-1660.
27. Pfeffer, S. R. 1992. GTP-binding proteins in intracellular transport. Trends Cell Biol. 2:41-46.
28. Regazzi, R., A. Kikuchi, Y. Takai, and C. B. Wollheim. 1992. The small GTP-binding proteins in the cytosol of insulin-secreting cells are complexed to GDP dissociation inhibitor proteins. J. Biol. Chem. 267:17512-17519.
29. Schnefel, S., P. Zimmermann, A. Pröfrock, R. Jahn, K. Aktories, S. Zeuzem, W. Haase, and I. Schulz. 1992. High- and small-molecular-weight GTP-binding proteins in zymogen granule membranes of rat pancreatic acinar cells. Cell Physiol. Biochem. 2:77-89.
30. Takai, Y., K. Kaibuchi, A. Kikuchi, and M. Kawata. 1992. Small GTP-binding proteins. Int. Rev. Cytol. 133:187-222.
31. Tooze, J., H. F. Kern, S. D. Fuller, and K. E. Howell. 1989. Condensation-sorting events in the rough endoplasmic reticulum of exocrine pancreatic cells. J. Cell Biol. 109:35-50.
32. Touchot, N., P. Chardin, and A. Tavitian. 1987. Four additional members of the ras gene superfamily isolated by an oligonucleotide strategy: molecular cloning of YPT-related cDNAs from a rat brain library. Proc. Natl. Acad. Sci. USA. 84:8210-8214.
33. Walworth, N. C., B. Goud, A. Kabcenell, and P. J. Novick. 1989. Mutational analysis of SEC4 suggests a cyclical mechanism for the regulation of vesicular traffic. EMBO (Eur. Mol. Biol. Organ.) J. 8:1685-1693.
34. Weibel, E. R., and R. P. Bolender. 1973. Stereological techniques for electron microscopy. In Principles and Techniques of Electron Microscopy. M. A. Hayat, editor. Van Nostrand Reinhold, New York. 237-296.
35. Zahraoui, A., N. Touchot, P. Chardin, and A. Tavitian. 1989. The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion. J. Biol. Chem. 264:12394-12401.