Low-dose α-tocopherol improves and high-dose α-tocopherol worsens endothelial vasodilator function in cholesterol-fed rabbits

Journal of Clinical Investigation

Volumn 93, Issue 2, 1994, Pages 844-851

  Keaney Jr , John F ^a   Gaziano, J Michael ^a   Xu, Aiming ^a   Frei, Balz ^b   Curran Celentano, Joanne ^c   Shwaery, Glenn T ^c   Loscalzo, Joseph ^a   Vita, Joseph A ^a,d  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c UNIVERSITY OF NEW HAMPSHIRE   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

antioxidants; endothelium derived relaxing factor; hypercholesterolemia; low density lipoproteins; vitamin E

Indexed keywords

ACETYLCHOLINE; ALPHA TOCOPHEROL; ANTIOXIDANT; CALCIMYCIN; CHOLESTEROL; COPPER; ENDOTHELIUM DERIVED RELAXING FACTOR; LOW DENSITY LIPOPROTEIN; NITROPRUSSIDE SODIUM; NORADRENALIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY INTIMA PROLIFERATION; ARTICLE; ATHEROSCLEROSIS; BLOOD VESSEL REACTIVITY; BLOOD VESSEL TONE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL INTAKE; CONTROLLED STUDY; HYPERCHOLESTEROLEMIA; LIPID OXIDATION; LIPOPROTEIN BLOOD LEVEL; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; VASCULAR ENDOTHELIUM; VASODILATATION;

EID: 0028177038     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI117039     Document Type: Article

References (54)

1. Furchgott, R. F., and J. V. Zawadzki. 1980. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature (Lond.). 288:373-376.
2. Kelm, M., and J. Schrader. 1990. Control of coronary vascular tone by nitric oxide. Circ. Res. 66:1561-1575.
3. Azuma, H., M. Ishikawa, and S. Sekizaki. 1986. Endothelium-dependent inhibition of platelet aggregation. Br. J. Pharmacol. 88:411-415.
4. Vita, J. A., C. B. Treasure, E. G. Nabel, J. M. McLenachan, R. D. Fish, A. C. Yeung, V. I. Vekshtein, A. P. Selwyn, and P. Ganz. 1990. Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease. Circulation. 81:491-497.
5. Kugiyama, K., S. A. Kerns, J. D. Morrisett, R. Roberts, and P. D. Henry. 1990. Impairment of endothelium-dependent arterial relaxation by lysolecithin in modified low-density lipoproteins. Nature (Lond.). 344:160-162.
6. Bossaller, C., G. B. Habib, H. Yamamoto, C. Williams, S. Wells, and P. D. Henry. 1987. Impaired muscarinic endothelium-dependent relaxation and cyclic guanosine 5′-monophosphate formation in atherosclerotic human coronary artery and rabbit aorta. J. Clin. Invest. 79:170-174.
7. Chin, J. H., S. Azhar, and B. B. Hoffman. 1992. Inactivation of endothelium-derived relaxing factor by oxidized lipoproteins. J. Clin, Invest. 89:10-18.
8. Inoue, N., K. Hirata, M. Yamada, Y. Hamamori, Y. Matsuda, H. Akita, and M. Yokoyama. 1992. Lysophosphatidylcholine inhibits bradykinin-induced phosphoinositide hydrolysis and calcium transients in cultured bovine aortic endothelial cells. Circ. Res. 71:1410-1421.
9. Morel, D. W., G. M. Hessler, and G. M. Chisolm. 1983. Low density lipoprotein cytotoxicity induced by free radical peroxidation of lipid. J. Lipid Res. 24:1070-1076.
10. Quinn, M. T., S. Parthasarathy, L. G. Fong, and D. Steinberg. 1987. Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherogenesis. Proc. Natl. Acad. Sci. USA. 84:2995-2998.
11. Gryglewski, R. J., R. M. Palmer, and S. Moncada. 1986. Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor. Nature (Lond.). 320:454-456.
12. Minor, R. L., Jr., P. R. Myers, R. Guerra Jr., J. N. Bates, and D. G. Harrison. 1990. Diet-induced atherosclerosis increases the release of nitrogen oxides from rabbit aorta. J. Clin. Invest. 86:2109-2116.
13. Burton, G. W., A. Joyce, and K. U. Ingold. 1983. Is vitamin E the only lipid-soluble, chain-breaking antioxidant in human plasma and erythrocyte membranes? Arch. Biochem. Biophys. 221:281-290.
14. Steinbrecher, U. P., S. Parthasarathy, D. S. Leake, J. L. Witztum, and D. Steinberg. 1984. Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids. Proc. Natl. Acad. Sci. USA. 81:3883-3887.
15. Dieber-Rotheneder, M., H. Puhl, H. Waeg, G. Streigl, and H. Esterbauer, 1991. Effect of oral supplementation with D-α-tocopherol on the vitamin E content of human low density lipoproteins and resistance to oxidation. J. Lipid Res. 32:1325-1332.
16. Riemersma, R. A., D. A. Wood, C. C. H. Macintyre, R. A. Elton, K. F. Gey, and M. F. Oliver, 1991. Risk of angina pectoris and plasma concentrations of vitamins A, C, E, and carotene. Lancet. 337:1-5.
17. Riemersma, R. A., D. A. Wood, C. C. H. Macintyre, R. A. Elton, K. F. Gey, and M. F. Oliver. 1989. Low plasma vitamin E and C and increased risk of angina in Scottish men. Ann. N. Y. Acad. Sci. 570:291-295.
18. Rimm, E. B., M. J. Stampfer, A. Ascherio, E. Giovannucci,G. A. Colditz, and W. C. Willett. 1993. Vitamin E consumption and the risk of coronary heart disease in men. N. Engl. J. Med. 328:1450-1456.
19. Stampfer, M. J.,C. H. Hennekens, J. E. Manson,G. A. Colditz, B. Rosner, and W. Willett. 1993. Vitamin E consumption and the risk of coronary disease in women. N. Engl. J. Med. 328:1444-1449.
20. Allain, C. C., L. S. Poon, C. S. Chen, W. Richmond, and P. C. Fu. 1974. Enzymatic determination of total serum cholesterol. Clin. Chem. 20:470-475.
21. Bucolo, G., and H. David. 1973. Quantitative determinations of serum triglycerides by the use of enzymes. Clin. Chem. 19:476-482.
22. 2. Clin. Chem. 29:2026-2030.
23. Retsky, K. L., M. W. Freeman, and B. Frei. 1993. Ascorbic acid oxidation product(s) protect human low density lipoprotein against atherogenic modification: Anti- rather than prooxidant activity of vitamin C in the presence of transition metal ions. J. Biol. Chem. 268:1304-1309.
24. Chung, B. H., J. P. Segrest, M. J. Ray, J. D. Brunzell, J. E. Hokanson, R. M. Krauss, K. Beaudrie, and J. T. Cone. 1986. Single vertical spin density gradient ultracentrifugation. Methods Enzym. 128:181-209.
25. Lowry, O. H., N. J. Rosebrough, A. L. Farr, and R. J. Randall. 1951. Protein measured with the folin phenol reagent. J. Biol. Chem. 193:265-275.
26. Esterbauer, H., H. Striegl, H. Puhl, and M. Rotheneder. 1989. Continuous monitoring of in vitro oxidation of human low density lipoprotein. Free Radical Res. Commun. 6:67-75.
27. Stocker, R., V. W. Bowry, and B. Frei. 1991. Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol. Proc. Natl. Acad. Sci. USA. 88:1646-1650.
28. Godfried, S. L., G. F. Combs, J. M. Saroka, and L. A. Dillingham. 1989. Potentiation of atherosclerotic lesions in rabbits by a high dietary level of vitamin E. Br. J. Nutr. 61:607-617.
29. Mangin, E. L., Jr., K. Kugiyama, J. H. Nguy, S. A. Kerns, and P. D. Henry. 1993. Effects of lysolipids and oxidatively modified low density lipoprotein on endothelium-dependent relaxation of rabbit aorta. Circ. Res. 72:161-166.
30. 2 activity of apoprotein B-100. Proc. Natl. Acad. Sci. USA. 87:9741-9745.
31. Steinbrecher, U. P., and P. H. Pritchard. 1989. Hydrolysis of phosphatidylcholine during LDL oxidation is mediated by platelet-activating factor acetylhydrolase. J. Lipid Res. 30:305-315.
32. Yokoyama, M., K. Hirata, R. Miyake, H. Akita, Y. Ishikawa, and H. Fukazaki. 1990. Lysophosphatidylcholine: essential role in the inhibition of endothelium-dependent vasorelaxation by oxidized low density lipoprotein. Biochem. Biophys. Res. Commun. 168:301-307.
33. Witztum, J. L., and D. Steinberg. 1991. Role of oxidized low density lipoprotein in atherogenesis. J. Clin. Invest. 88:1785-1792.
34. Navab, M., S. S. Imes, S. Y. Hama, G. P. Hough, L. A. Ross, R. W. Bork, A. J. Valente, J. A. Berliner, D. C. Drinkwater, H. Laks, et al. 1991. Monocyte transmigration induced by modification of low density lipoprotein in cocultures of human aortic wall cells is due to induction of monocyte chemotactic protein 1 synthesis and is abolished by high density lipoprotein. J. Clin. Invest. 88:2039-2046.
35. Fantone, J. D., and P. A. Ward. 1982. Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions. Am. J. Pathol. 107:397-403.
36. Ignarro, L. J., G. M. Buga, K. S. Wood, R. E. Byrns, and G. Chaudhuri. 1987. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc. Natl. Acad. Sci. USA. 84:9265-9269.
37. Myers, P. R., R. L. Minor, Jr., R. Guerra, Jr., J. N. Bates, and D. G. Harrison. 1990. Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocysteine than nitric oxide. Nature (Lond.). 345:161-163.
38. Stamler, J. S., D. J. Singel, and J. Loscalzo. 1992. Biochemistry of nitric oxide and its redox-activated forms. Science. 258:1898-1902.
39. 2. Implications for the action of endothelium-derived relaxing factor (EDRF). Free. Radical Res. Commun. 10:221-226.
40. Beckman, J. S., T. W. Beckman, J. Chen, P. A. Marshall, and B. A. Freeman. 1990. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc. Natl. Acad. Sci. USA. 87:1620-1624.
41. Ohara, Y., T. E. Peterson, and D. G. Harrison. 1993. Hypercholesterolemia increases endothelial superoxide anion production. J. Clin. Invest. 91:2546-2551.
42. Mugge, A., J. H. Elwell, T. E. Peterson, T. G. Hofmeyer, D. D. Heistad, and D. G. Harrison. 1991. Chronic treatment with polyethylene-glycolated superoxide dismutase partially restores endothelium-dependent vascular relaxations in cholesterol-fed rabbits. Circ. Res. 69:1293-1300.
43. Westrope, K. L., R. L. Miller, and R. B. Wilson. 1982. Vitamin E in a rabbit model of endogenous hypercholesterolemia and atherosclerosis. Nutr. Rep. Int. 25:83-88.
44. Williams, R. J., J. M. Motteram, C. H. Sharp, and P. J. Gallagher. 1992. Dietary vitamin E and the attenuation of early lesion development in modified Watanabe rabbits. Atherosclerosis. 94:153-159.
45. Wilson, R. B., C. C. Middleton, and G. Y. Sun. 1978. Vitamin E. antioxidants and lipid peroxidation in experimental atherosclerosis on rabbits. J. Nutr. 108:1858-1867.
46. Dam, H. 1944. Ineffectiveness of vitamin E in preventing cholesterol deposition in the aorta. J. Nutr. 28:289-295.
47. Frei, B., L. England, and B. N. Ames. 1989. Ascorbate is an outstanding antioxidant in human blood plasma. Proc. Natl. Acad. Sci. USA. 86:6377-6381.
48. Ames, B. N., R. Cathcart, E. Schwiers, and P. Hochstein. 1981. Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis. Proc. Natl. Acad. Sci. USA. 78:6858-6862.
49. Steinberg, D., S. Parthasarathy, T. E. Carew, J. C. Khoo, and J. L. Witztum. 1989. Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. N. Engl. J. Med. 320:915-924.
50. Parthasarathy, S., S. G. Young, J. L. Witztum, R. C. Pittman, and D. Steinberg. 1986. Probucol inhibits oxidative modification of low density lipoprotein. J. Clin. Invest. 77:641-644.
51. Parthasarathy, S. 1992. Evidence for an additional intracellular site of action of probucol in the prevention of oxidative modification of low density lipoprotein: Use of a new water-soluble probucol derivative. J. Clin. Invest. 89:1618-1621.
52. Bowry, V., K. U. Ingold, and R. Stocker. 1992. Vitamin E in human low-density lipoprotein, when and how this antioxidant becomes a pro-oxidant. Biochem. J. 288:341-344.
53. de Groot, H., U. Hegi, and H. Sies. 1993. Loss of alpha-tocopherol upon exposure to nitric oxide or the sydnonimine SIN-1. FEBS. Lett. 315:139-142.
54. Cooney, R. V., A. A. Franke, P. J. Harwood, V. Hatch-Pigott, L. J. Cuater, and L. J. Mordan. 1993. Gamma-tocopherol detoxification of nitrogen dioxide: superiority to alpha-tocopherol. Proc. Natl. Acad. Sci. USA. 90:1771-1775.