Protection by transfected glutathione S-transferase isozymes against carcinogen-induced alkylation of cellular macromolecules in human MCF-7 cells

Carcinogenesis

Volumn 15, Issue 6, 1994, Pages 1155-1160

  Fields, Wanda R ^a,b   Li, Ying ^a,b   Townsend, Alan J ^a,b  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b WAKE FOREST UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 NITROQUINOLINE 1 OXIDE; ANTINEOPLASTIC AGENT; CARCINOGEN; CELL DNA; ENZYME INHIBITOR; ETACRYNIC ACID; GLUTATHIONE TRANSFERASE; ISOENZYME; NUCLEIC ACID;

ALKYLATION; ARTICLE; CANCER CELL CULTURE; CELL CLONE; CELL STRAIN MCF 7; CLONOGENIC ASSAY; CONJUGATION; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME SUBSTRATE; GENETIC TRANSFECTION; GENOTOXICITY; HUMAN; HUMAN CELL; MACROMOLECULE; PRIORITY JOURNAL;

4-NITROQUINOLINE-1-OXIDE; ALKYLATION; BREAST NEOPLASMS; FEMALE; GLUTATHIONE TRANSFERASE; HUMAN; ISOENZYMES; NUCLEIC ACIDS; PROTEINS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0028176726     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/15.6.1155     Document Type: Article

References (35)

1. Weinstein, I.B. (1988) The origins of human cancer: molecular mechanisms of carcinogenesis and their implications for cancer prevention and treatment-Twenty-Seventh G.H.A. Clowes Memorial Lecture. Cancer Res., 48, 4135-4143
2. Harris, C. C. (1991) Chemical and physical carcinogenesis: Advances and perspectives for the 1990s. Cancer Res., 51, 5023s-5044s
3. Pitot, H. C. and Dragan, Y. P. (1991) Facts and theories concerning the mechanisms of carcinogenesis. FASEB J., 5, 2280 -2286
4. Coles, B. and Ketterer, B. (1990) The role of glutathione and glutathione transferases in chemical carcinogenesis. Crit. Rev. Biochem. Mol. Biol., 25, 47-70
5. Jakoby, W. B. (ed.) (1980) The Enzymatic Basis of Detoxification. Academic Press, New York, NY
6. Mannervik, B., Awasthi, Y.C al. (1992) Nomenclature for human glutathione transferases. Biochem. J., 282, 305 -306
7. Ketterer, B. (1988) Protective role of glutathione and glutathione transferases in mutagenesis and carcinogenesis. Mum. Res., 202, 343 -361
8. Black, S. M. and Wolf, C. R. (1991) The role of glutathione-dependent enzymes in drug resistance. Pharmacol. Ther., 51, 139-154
9. Morrow, C. S. and Cowan, K. H. (1990) Glutathione S-transferases and drug resistance. Cancer Cells, 2, 15 -17
10. Townsend, A J. and Cowan, K. H. (1989) Glutathione S-transferases and drug resistance (review). Cancer Bull., 41, 31-37
11. Hosting, L. K., Whelan, R., Shellard, S. A., Bedford, P. and Hill, B. T. (1990) An evaluation of the role of glutathione and its associated enzymes in the expression of differential sensitivities to antitumour agents shown by a range of human tumour cell lines. Biochem. Pharmacol., 40, 1833-1842
12. Yusa, K., Hamada, H. and Tsuruo, T. (1988) Comparison of glutathione S-transferase activity between drag-resistant and -sensitive human tumor cells: Is glutathione S-transferase associated with multidrag resistance? Cancer Chemother. Pharmacol., 22, 17 -20
13. Moscow J. A., Townsend, A. J. and Cowan, K. H. (1989) Elevation of pi class glutathione S-transferase activity in human breast cancer cells by transfection of the GST[pi] gene and its effect on sensitivity to toxins. MoL Pharmacol., 36, 22-28
14. Leyland-Jones, B., Townsend, A. J., Tu, C. P., Cowan, K. H. and Goldsmith, M. E. (1991) Antineoplastic drag sensitivity of human MCF-7 breast cancer cells stably transfected with a human alpha class glutathione S-transferase gene. Cancer Res., 51, 587 -594
15. Townsend, A.J., Tu, C. P. and Cowan, K. H. (1992) Expression of human mu or alpha class glutathione S-transferases in stably transfected human MCF-7 breast cancer cells: Effect on cellular sensitivity to cytotoxic agents. Mol. Pharmacol., 41, 230 -236
16. Ciaccio, P. J., Tew, K. D. and LaCreta, F. P. (1991) Enzymatic conjugation of chlorambucil with glutathione by human glutathione S-transferases and inhibition by ethacrynic acid. Biochem. Pharmacol., 42, 1504-1507
17. Meyer, D J., Gilmore, K. S., Harris, J.M., Hartley, J.A. and Ketterer, B. (1992) Chlorambucil-monoglutathkmyl conjugate is sequestered by human alpha class glutathione S-transferases. Br. J. Cancer, 66, 433-438
18. Nagao, M. and Sugimura, T. (1976) Molecular biology of the carcinogen, 4-nitroquinoline-l-oxide. Adv. Cancer Res., 23, 131-169
19. Bailleul, B., Daubersies, P., Galiegue, Z. S. and Loucheux, L. M. (1989) Molecular basis of 4-nitroquinoline 1-oxide carcinogenesis. Jpn. J. Cancer Res., 80, 691-697
20. Goth, G. R., Tinckne, U.B.P. and Hughes, M. (1984) Toxicity of 4-nitroquinoline 1-oxide in Chinese hamster ovary cells: Influence of cell density and of position in the cell cycle. Mum. Res., 140, 209-213
21. Tsuda, H. (1990) Role of DT diaphorase in the cytotoxicity of menadione and 4-nitroquinoline-l-oxide in cultured mammalian fibroblastic cells. Cancer Lett., 55, 195-199
22. Stanley, J.S. and Benson, A.M. (1988) The conjugation of 4-nitroquinoline 1-oxide, a potent carcinogen, by mammalian glutathione transferases.Nitroquinoline 1-oxide conjugation by human, rat and mouse liver cytosols, extrahepatic organs of mice and purified mouse glutathione transferase isoenzymes. Biochem. J., 256, 303 -306
23. Townsend, A. J., Goldsmith, M. E., Pickett, C.B. and Cowan, K. H. (1989) Isolation, characterization, and expression in Escherichia coli of two murine mu class glutathione S-transferase cDNAs homologous to the rat subunits 3 (Ybl) and 4 (Yb2). J. Biol. Chem., 264, 21582 -21590
24. Habig, W.H. and Jakoby, W.B. (1981) Assays for differentiation of glutathione transferases. Methods Enzymol., Tl, 398-405
25. Townsend, A.J. and Cowan, K.H. (1990) Expression in E. coli and characterization of two murine mu class glutathione S-transferase isoenzymes homologous to rat subunits 3 (Ybl) and 4 (Yb2). Proc. Am. Assoc. Cancer Res., 31, 31
26. Whelan, R.D., Hosking, L.K., Townsend, A.J., Cowan, K.H. and Hill, B.T. (1989) Differential increases in glutathione S-transferase activities in a range of multidrug resistant human tumor cell lines. Cancer Common., 1, 359 -365
27. Tew, K.D., Pickett, C.B., Mantle, T.J., Mannervik, B. and Hayes, J.D. (eds) (1993) Structure and Function of Glutathione Transferases. CRC Press, Boca Raton, FL
28. Tahir, M.K. and Mannervik, B. (1986) Simple inhibition studies for distinction between bomodimeric and heterodimeric isoenzymes of glutathione transferase. Biochem. J., 261, 1048-1051
29. Kensler, T.W., Egner, P.A., Davidson, N.E., et aL (1986) Modulation of aflatoxin metabolism, aflaloxin-N7-guanine formation, and hepatic tumorigenesis in rats fed ethoxyquin: role of induction of glutathione S-transferases. Cancer Res., 46, 3924 -3931
30. Bell, D.A., Taylor, J.A., Paulson, D.F., et al. (1993) Genetic risk and carcinogen exposure: A common inherited defect of the carcinogen-metabolism gene glutathione S-transferase Ml (GSTM1) that increases susceptibility to bladder cancer. J. Natl Cancer Inst., 85, 1159-1164
31. Seidegird, J., Peto, R.W., Markowitz, M.M., et al. (1990) Isoenzyme(s) of glutathione transferase (class Mu) as a marker for the susceptibility to lungcancer: A follow up study. Carcinogenesis, 11, 33-36
32. Wooley, P.V., Tew, K.D. and Carter, S.K. (1988) Mechanisms of Drug Resistance in Neoplastic Cells (Bristol-Myers Symposia Vol. 9). Academic Press, New York, NY
33. Smith, M.T., Evans, C.G., Doane, S.P., et al. (1989) Denitrosation of l, 3-bis(2-chloroethyI)-l-nitrosourea by class mu glutathione transferases and its role in cellular resistance in rat brain tumor cells. Cancer Res., 49, 2621-2625
34. Bolton, M.G., Colvin, O.M. and Hilton, J. (1991) Specificity of isoenzymes of murine hepatic glutathione S-transferase for the conjugation of glutathione with L-phenylalanine mustard. Cancer Res., 51, 2410-2415
35. Stanleyj, S., York, J.L., Benson, A.M. (1992). Nitroreductases and glutathione transferases that act on 4-nitroquinoline 1-oxide and their differential induction by butylaled hydroxyanisole in mice. Cancer Res. 52, 58-63