The vanilloid (capsaicin) receptor: Receptor types and species differences

General Pharmacology

Volumn 25, Issue 2, 1994, Pages 223-243

  Szallasi, Arpad ^a  

^a Department of Pharmacology Menarini Richerche Sud Via Tito Speri 10 00040 Pomezia ^*

Author keywords

[No Author keywords available]

Indexed keywords

CAPSAICIN; CAPSAICIN DERIVATIVE; CAPSAZEPINE; DRUG RECEPTOR; RADIOISOTOPE; RECEPTOR SUBTYPE; RESINIFERATOXIN; VANILLOID RECEPTOR;

AIRWAY; BINDING AFFINITY; BLADDER; COLON; GUINEA PIG; HAMSTER; HUMAN; MOUSE; MUSCLE SPINDLE AFFERENT NERVE; NERVOUS SYSTEM; NONHUMAN; PAIN; PRIORITY JOURNAL; RABBIT; RAT; REVIEW; SPECIES DIFFERENCE;

ANIMAL; CAPSAICIN; HUMAN; RECEPTORS, DRUG; SPECIES SPECIFICITY;

EID: 0028175616     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/0306-3623(94)90049-3     Document Type: Review

References (181)

1. Selective modulation of NMDA responses by reduction and oxidation
2. 2+ and temperature
3. Ruthenium red as a capsaicin antagonist
4. The effects of locally applied capsaicin on conduction in cutaneous nerves of four mammalian species
5. Neurogenic hyperalgesia: the search for the primary cutaneous afferent fibers that contribute to capsaicin-induced pain and hyperalgesia
6. 1-acid glycoprotein binding
7. Capsazepine as a selective antagonist of capsaicin-induced activation of C-fibres in guinea-pig bronchi
8. Sensory neuron-specific actions of capsaicin: mechanisms and applications
9. Protons activate a cation conductance in a sub-population of rat dorsal root ganglion neurons
10. The mechanism of action of capsaicin—a sensory neurotoxin
11. Capsazepine: a competitive antagonist of the sensory neurone excitant capsaicin
12. Quantitative monitoring of acute experimental cutaneous pain and inflammatory vascular reactions
13. The effect of capsaicin on voltage-gated calcium currents and calcium signals in cultured dorsal root ganglion cells
14. The neuropharmacology of capsaicin: review of some recent observations
15. Relaxant innervation of the guinea-pig trachealis: demonstration of capsaicin-sensitive and -insensitive vagal pathways
16. Topical capsaicin in the treatment of cutaneous disorders
17. Differential inhibition of potassium currents in rat ventricular myocytes by capsaicin
18. To classify or not to classify that is the question
19. Opiate receptor: cooperativity of binding observed in brain slices
20. How does the B-afferent classification apply to vagal afferent neurons
21. Thermoregulatory effects of resiniferatoxin in the mouse: comparison with capsaicin
22. A spinal mechanism of action is involved in the antinociception produced by the capsaicin analogue olvanil
23. Capsaicin causes prolonged inhibition of voltage-activated calcium currents in adult rat dorsal root ganglion neurons in culture
24. Neurochemistry of visceral afferent neurons
25. Different biological targets for resiniferatoxin and phorbol 12-myristate 13-acetate
26. Specific binding of phorbol ester tumor promoters
27. Cytochemical and physiological properties of sensory and dorsal horn neurones that transmit cutaneous sensation
28. Neuropharmacological mechanisms of capsaicin and related substances
29. + channels in the frog node of Ranvier
30. Topical capsaicin therapy for neuropathic pain
31. Stress, symmetry, and psoriasis: possible role of neuropeptides
32. Equilibrium binding of acetylcholine to the membrane-bound acetylcholine receptor
33. Pain pathways
34. The involvement of neurokinin receptor subtypes in somatosensory processing in the superficial dorsal horn of the cat
35. A study of the acyl vanillylamides2
36. Intravesical capsaicin for neurogenic bladder dysfunction
37. Capsazepine inhibits low pH- and lactic acid-evoked release of calcitonin gene-related peptide from sensory nerves in guinea-pig heart
38. The human pharmacology of capsaicin
39. 1-acid glycoprotein (orosomucoid)
40. Glutamate, nitric oxide and cell-cell signaling in the nervous system
41. Biological disulfides: the third messenger
42. Acute toxicity of capsaicin in several animal species
43. Capsaicin prolongs action potential duration in cultured sensory neurones
44. The interaction of drugs and plasma proteins
45. 3H]resiniferatoxin binding to the vanilloid receptor
46. Topical capsaicin protects against trinitrobenzene sulfonic acid (TNB)-induced colitis in the rat: characterization of the vanilloid (capsaicin) receptor involved
47. Resiniferatoxin-induced loss of vanilloid receptors is reversible in the urinary bladder but not the spinal cord of the rat
48. Tachykinin receptor types: classification and membrane signalling mechanisms
49. Evidence for spinal N-methyl-D-aspartate receptor involvement in prolonged chemical nociception in the rat
50. The effects of a series of capsaicin analogs on nociception and body temperature in the rat
51. Resiniferatoxin and other esters of novel polyfunctional diterpenes from Euphorbia resinifera and unispina
52. Changes in features of degenerating primary sensory neurons with time after capsaicin treatment
53. Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides
54. Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons
55. Beitrage zur physiologischen Wirkung der Bestandteile des Capsicum annuum
56. Long-lasting agonist activity produced by a capsaicin-like photoaffinity probe
57. 3H]resiniferatoxin to capsaicin-sensitive sensory neurons: regulation by nerve growth factor
58. Role of the nerve terminals in the mechanisms of inflammatory reactions
59. Desensitization with capsaicin and related acylamides as a tool for studying the function of pain receptors
60. Pain and inflammation induced by nicotine acetylcholine and structurally-related compounds and their prevention by desensitizing agents
61. B-afferents a system of capsaicin-sensitive primary sensory neurons
62. Possible use of capsaicin in pain therapy
63. Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones
64. Neurotoxin induced nerve cell degeneration: possible involvement of calcium
65. Selective degeneration by capsaicin of a subpopulation of primary sensory neurons in the adult rat
66. J. Physiol. (London)
67. Capsaicin-induced depletion of substance P from primary sensory neurons
68. Excitatory transmission in the dorsal horn is in part mediated through APV-sensitive NMDA receptors
69. Mitochondrial alterations in the spinal ganglion cells of the rat accompanying the long-lasting sensory disturbance induced by capsaicin
70. 1-acid glycoprotein infusion in the rat
71. Visceral autonomic or just plain small dark neurones
72. Neonatal capsaicin is not specific neurotoxin for sensory C-fibers or small dark cells in rat dorsal root ganglia
73. Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complex
74. Classification of peripheral neurones
75. Redox modulation of NMDA receptor-mediated toxicity in mammalian central neurons
76. Nerve growth factor regulates expression of neuropeptide genes in adult sensory neurons
77. Size of the acetylcholine receptors in the membrane
78. Inhibition of low pH evoked activation of airway sensory nerves by capsazepine, a novel capsaicin-receptor antagonist
79. Capsaicin-induced desensitization of airway mucosa to cigarette smoke, mechanical and chemical irritants
80. Capsaicin: actions on nociceptive C-fibers and therapeutic potential
81. β-Adrenergic receptors of brain cells
82. Glial and neuronal opioid receptors: apparent positive cooperativity observed in intact cultured cells
83. Can capsaicin be used to discriminate between subpopulations of B-afferents
84. Capsaicinand primary afferent neurons: from basic science to human therapy
85. Therapeutic potential of capsaicin-like molecules: studies in animals and humans
86. The sensory-efferent function of capsaicin-sensitive sensory neurons
87. Species-related variations in the effects of capsaicin on urinary bladder functions: relation to bladder content of substance P-like immunoreactivity
88. Cystometric evidence that capsaicin-sensitive nerves modulate the afferent branch of micturition reflex in humans
89. Similarities and differences in the action of resiniferatoxin and capsaicin on central and peripheral endings of primary sensory neurons
90. A comparison of capsazepine and ruthenium red as capsaicin antagonists in the rat isolated urinary bladder and vas deferens
91. Tachykinin receptors and tachykinin receptor antagonists
92. Regulation of the NMDA receptor by redox phenomena: inhibitory role of ascorbate
93. Receptor binding sites for substance P but not substance K or neuromedin K are expressed in high concentrations by arterioles, venules and lymph nodules in surgical specimens obtained from patients with ulcerative colitis and Crohn disease
94. Receptors for sensory neuropeptides in human inflammatory diseases: implications for the effector role of sensory neurons
95. Novel classes of nociceptors: beyond Sherrington
96. Pharmacological and neurochemical evidence for the activation of capsaicin-sensitive nerves by lipoxin A4 in guinea pig bronchus
97. Glutathione
98. Nitric oxide (NO) and nociceptive processing in the spinal cord
99. Neonatal capsaicin treatment prevents the development of the thermal hyperalgesia produced in a model of neuropathic pain in the rat
100. The binding of drugs by plasma proteins
101. Capsaicinoid-induced local and systemic antinociception without substance P depletion
102. Regulation of substance P by nerve growth factor: disruption by capsaicin
103. Interactions of capsaicinoids with drug-metabolizing systems: relationship to toxicity
104. Capsaicin—a literature survey
105. Methods for analyzing and interpreting cooperativity in dose-response curves—I. Antagonist effects on angiotensin receptors in smooth muscle
106. Capsaicin's action on the nervous system
107. Dose-dependent effects of capsaicin on primary sensory neurons in the neonatal rat
108. The role of neurokinin and N-methyl-d-aspartate receptors in synaptic transmission from capsaicin-sensitive primary afferents in the rat spinal cord in vitro
109. Interactions between visceral and cutaneous nociception in the rat. I. Noxious cutaneous stimuli inhibit visceral nociceptive neurons and reflexes
110. Interactions between visceral and cutaneous nociception in the rat. II. Noxious visceral stimuli inhibit cutaneous nociceptive neurons and reflexes
111. The role of protein kinase C in cell surface signal transduction and tumor promotion
112. Nerve growth factor antagonizes the neurotoxic action of capsaicin on primary sensory neurons
113. Capsaicin-induced relaxation in the isolated rat external urethral sphincter: characterization of the vanilloid receptor and mediation by CGRP
114. Further evidence for the existence of long ascending unmyelinated primary afferent fibers within the dorsal funiculus: effects of capsaicin
115. Capsazepine reversal of the antinociceptive action of capsaicin in vivo
116. NK1 receptor gene expression is increased in asthmatic lung and reduced by corticosteroids
117. The effect of capsaicin on afferent nerves and temperature regulation of mammals and birds
118. B-afferents: a fundamental division of the nervous system mediating homeostasis?
119. Neurons that subserve sensory-discriminative aspects of pain
120. A cytoarchitectonic atlas of the spinal cord
121. Capsaicin-sensitivity and the sensory vagus do these exceptions prove or disprove the B-neuron rule for autonomic afferents?
122. Capsaicin: a probe for studying specific neuronal populations in brain and retina
123. Topical capsaicin in dermatologic and peripheral pain disorders
124. Acetylcholine receptor enriched membranes: acetylcholine binding and excitability after reduction in vitro
125. Investigations into the skin-irritant properties of resiniferonol ortho esters
126. Effect of exposure to anti-NGF on sensory neurons of adult rats and guinea pigs
127. Capsaicin and its analogs inhibit the activity of NADH-Coenzyme Q oxidoreductase of the mitochondrial respiratory chain
128. A-fibers mediate mechanical hyperesthesia and allodynia and C-fibers mediate thermal hyperalgesia in a new model of causalgiform pain disorders in rats
129. Early and late effects of prolonged topical capsaicin on cutaneous sensibility and neurogenic vasodilatation in humans
130. The effects of capsaicin on human skin, liver and epidermal lysosomes
131. Nitric oxide as a neuronal messenger
132. resiniferatoxin, a phorbol-related diterpene, acts as an ultrapotent analog of capsaicin, the irritant constituent in red pepper
133. Specific binding of resiniferatoxin, an ultrapotent capsaicin analog, by dorsal root ganglion membranes
134. Resiniferatoxin and its analogs provide novel insights into the pharmacology of the vanilloid (capsaicin) receptor
135. Molecular target size of the vanilloid (capsaicin) receptor in pig dorsal root ganglia
136. Characterization of vanilloid receptors in the dorsal horn of pig spinal cord
137. Vanilloid receptor loss in rat sensory ganglia associated with long term desensitization to resiniferatoxin
138. Resiniferatoxin
139. 3H]resiniferatoxin binding by the vanilloid receptor: species-related differences, effects of temperature and sulfhydryl reagents
140. Mechanisms and therapeutic potential of vanilloids (capsaicin-like molecules)
141. Structure-activity analysis of resiniferatoxin analogs
142. Duration of desensitization and ultrastructural changes in dorsal root ganglia in rats treated with resiniferatoxin, an ultrapotent capsaicin analog
143. Permanent effects of neonatally administered resiniferatoxin in the rat
144. 3H]resiniferatoxin binding to rat dorsal root ganglion membranes as a novel approach in evaluating compounds with capsaicin-like activity
145. 1-acid glycoprotein (orosomucoid) as a major vanilloid-binding protein in serum
146. 3H]resiniferatoxin binding to central (dorsal root ganglia, spinal cord) and peripheral (urinary bladder, airways) vanilloid (capsaicin) receptors in the rat
147. Vanilloid (capsaicin) receptor in the rat: positive cooperativity of resiniferatoxin binding and its modulation by reduction and oxidation
148. Characterization of a peripheral vanilloid (capsaicin) receptor in the rat urinary bladder
149. Vanilloid receptors in the urinary bladder: regional distribution, localization on sensory nerves, and species-related differences
150. 3H]resiniferatoxin binding of vanilloid (capsaicin) receptors in guinea pig airways: regional differences, and affinity for capsazepine
151. Effects of subacute capsaicin treatment on local cerebral glucose utilization in the rat
152. A pharmacological approach to the elucidation of the role of different nerve fibers and receptor endings in mediation of pain
153. Capsaicin type pungent agents producing pyrexia
154. Capsaicin-sensitive chemoceptive neural system with dual sensory-efferent function
155. Effect of capsaicin, resiniferatoxin and piperine on ethanol-induced gastric ulcer of the rat
156. Capsaicin-sensitive chemoceptive B-afferents a neural system with dual sensory-efferent function
157. Perspectives of capsaicin-type agents in pain therapy and research
158. Sensory effects of capsaicin congeners. I. Relationship between chemical structure and pain-producing potency
159. Sensory effects of capsaicin congeners. II. Importance of chemical structure and pungency in desensitizing activity of capsaicin-type compounds
160. Capsaicin-sensitive non-cholinergic excitatory innervation of the guinea pig tracheobronchial smooth muscle
161. Mitochondrial changes in preoptic neurones after capsaicin desensitization of the hypothalamic thermodetectors in rats
162. Resiniferatoxin, an ultrapotent selective modulator of capsaicin-sensitive primary afferent neurons
163. Resiniferatoxin a selective neurotoxin of capsaicin-sensitive neurons
164. Capsaicin-sensitive bronchopulmonary receptors with dual sensory-efferent function: mode of action of capsaicin antagonists
165. Long lasting inhibition of horseradish peroxidase (HPR) transport in sensory nerves induced by capsaicin treatment of the receptive field
166. Capsaicin-induced inhibition of axoplasmic transport is prevented by nerve growth factor
167. Effects of capsaicin on rat liver S9-mediated metabolism and DNA binding of aflatoxin
168. The binding of drugs to blood plasma macromolecules: recent advances and therapeutic significance
169. Pharmacologic actions of capsaicin: apparent involvement of substance P and serotonin
170. Respiratory reflexes
171. Nerve growth factor (NGF) regulates adult rat cultured dorsal root ganglion neuron responses to the excitotoxin capsaicin
172. Cellular mechanism of action of resiniferatoxin: a potent sensory neuron excitotoxin
173. Capsaicin-induced ion fluxes in dorsal root ganglion cells in culture
174. Immunochemical detection of photoaffinity-labelled capsaicin-binding proteins from sensory neurons
175. Effects of intrathecal capsaicin and an NK-1 antagonist, CP, 96345, on the thermal hyperalgesia observed following unilateral constriction of the sciatic nerve in the rat
176. Conduction block induced by capsaicin in crayfish giant axon
177. Inhibition by capsaicin of NADH-quinone oxidoreductases is correlated with the presence of energy-coupling site 1 in various organisms
178. Capsaicin desensitization in rat dorsal root ganglion neurones is due to activation of calcineurin
179. Possible mode of action of capsaicin in heart and uterus
180. Tumor initiators and promoters in the induction of Epstein-Barr virus