Coenzyme Q10 and nicotinamide block striatal lesions produced by the mitochondrial toxin malonate

Annals of Neurology

Volumn 36, Issue 6, 1994, Pages 882-888

  Beal, M Flint ^a   Henshaw, D Ross ^a   Jenkins, Bruce G ^b   Rosen, Bruce R ^b   Schulz, Jourg B ^a  

^a Nuclear Magnetic Resonance Center   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG DERIVATIVE; MALONIC ACID; MALONIC ACID DERIVATIVE; NICOTINAMIDE; UBIDECARENONE; UBIQUINONE; ADENOSINE TRIPHOSPHATE; EXCITOTOXIN; LACTIC ACID; N ACETYLASPARTIC ACID; RIBOFLAVIN; UNCLASSIFIED DRUG; VITALINE;

ANIMAL; ARTICLE; CORPUS STRIATUM; DOSE RESPONSE; DRUG EFFECT; MALE; METABOLISM; MITOCHONDRION; NUCLEAR MAGNETIC RESONANCE IMAGING; RAT; RAT STRAIN; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BRAIN INJURY; BRAIN PROTECTION; CONTROLLED STUDY; INTRAPERITONEAL DRUG ADMINISTRATION; MITOCHONDRIAL RESPIRATION; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RESPIRATORY CHAIN; STRIATE CORTEX; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMAL; CORPUS STRIATUM; DOSE-RESPONSE RELATIONSHIP, DRUG; MAGNETIC RESONANCE IMAGING; MALE; MALONATES; MITOCHONDRIA; NIACINAMIDE; RATS; RATS, SPRAGUE-DAWLEY; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; UBIQUINONE;

EID: 0028173480     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.410360613     Document Type: Article

References (39)

1. Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?
2. Alternative excitotoxic hypotheses
3. Glutamate becomes neurotoxic via the N‐methyl‐D‐aspartate receptor when intracellular energy levels are reduced
4. Aminooxyacetic acid results in excitotoxin lesions by a novel indirect mechanism
5. 1‐Methyl‐4‐phenylpyridinium produces excitotoxic lesions in rat striatum as a result of impairment of oxidative metabolism
6. Age‐dependent striatal excitotoxic lesions produced by the endogenous mitochondrial inhibitor malonate
7. Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3‐nitropropionic acid
8. Age‐dependent vulnerability of the striatum to the mitochondrial toxin 3‐nitropropionic acid
9. Both local and systemic administration of the mitochondrial toxin sodium azide result in striatal lesions by an excitotoxic mechanism
10. Inhibition of succinate dehydrogenase by malonic acid produces an excitotoxic lesion in rat striatum
11. Malonate produces striatal lesions by indirect NMDA receptor activation
12. 10
13. 31P NMR study
14. 10 and idebenone
15. Spontaneous Kearns/sayre/chronic external ophthalmoplegia plus syndrome associated wit a mitochondiral DNA deletion: a slip‐replication model and metabolic therapy
16. Marked reduction in CSF lactate and pyruvate levels after CoQ therapy in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke‐like episodes (MELAS)
17. 31P magnetic resonance spectroscopy during treatment with nicotinamide and riboflavin
18. The enzymatic measurements of adenine nucleotides and P‐creatinine in picomole amounts
19. Fluorometric assays of proteins in the nanogram range
20. Localized proton NMR spectroscopy in different regions of the human brain in vivo. Relaxation times and concentrations of cerebral metabolites
21. Therapy of mitochondrial disorders
22. Ubiquinol‐10 is an effective lipidsoluble antioxidant at physiological concentrations
23. Transfer of exogenous coenzyme Q to inner membrane of heart mitochondria in rats
24. Lateral diffusion of ubiquinone during electron transfer in phospholipid‐ and ubiquinone‐enriched mitochondrial membrane
25. 10 on ischemia and reperfusion of the isolated perfused rat heart
26. Ubiquinone protects cultured neurons against spontaneous and excitotoxininduced degeneration
27. 10 with multiple vitamins is generally ineffective in treatment of mitochondrial disease
28. Improved brain and muscle energy metabolism in patients with mitochondrial cytopathies treated with coenzyme
29. Localized proton MR spectroscopy of metabolic brain disorders in children
30. Treatment of complex I deficiency with riboflavin
31. 10 in the rat following its oral and intraperitoneal administration
32. Involvement of free radicals in excitotoxicity in vivo
33. Effect of high doses of dietary vitamin E on the concentrations of vitamin E in several brain regions, plasma, liver, and adipose tissue in rats
34. Hydrogen peroxide‐induced injury of cells and its prevention by inhibitors of poly(ADP‐ribose) polymerase
35. Nitric oxide activation of poly(ADP‐ribose) synthetase in neurotoxicity
36. Ubiquinone lowers occipital lactate levels in patients with Huntington's disease
37. Selective blockade of N‐methyl‐D‐aspartate (NMDA)‐induced convulsions by NMDA antagonists and putative glycine antagonists: relationship with phencyclidinelike behavioral effects
38. Selective impairment of learning and blockade of LTP by an NMDA receptor antagonist AP5