Clozapine is a potent and selective muscarinic M4 receptor agonist

European Journal of Pharmacology: Molecular Pharmacology

Volumn 269, Issue 3, 1994, Pages

  Zorn, Stevin H ^a   Jones, Shawn B ^a   Ward, Karen M ^a   Liston, Dane R ^a  

^a PFIZER INC   (United States)

Author keywords

Clozaril; Human; Neuroleptic

Indexed keywords

CARBACHOL; CLOZAPINE; CYCLIC AMP; FORSKOLIN; INOSITOL PHOSPHATE; ISOBUTYLMETHYLXANTHINE; METHYLSCOPOLAMINE; MUSCARINIC AGENT; MUSCARINIC M4 RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; NEUROLEPTIC AGENT; RADIOLIGAND; RECEPTOR SUBTYPE;

ANIMAL CELL; ARTICLE; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG POTENCY; DRUG SELECTIVITY; GENE EXPRESSION; HUMAN; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL;

ANIMAL; CARBACHOL; CHO CELLS; CLOZAPINE; CRICETULUS; CYCLIC AMP; FORSKOLIN; HAMSTERS; HUMAN; HYDROLYSIS; MUSCARINIC AGONISTS; N-METHYLSCOPOLAMINE; PARASYMPATHOLYTICS; PHOSPHATIDYLINOSITOLS; SALIVATION; SCOPOLAMINE DERIVATIVES;

EID: 0028172955     PISSN: 09224106     EISSN: None     Source Type: Journal    
DOI: 10.1016/0922-4106(94)90047-7     Document Type: Article

References (8)

1. Clozapine is a potent and selective muscarinic antagonist at the five cloned human muscarinic acetylcholine receptors expressed in CHO-K1 cells
2. The striatum and cerebral cortex express different muscarinic receptor mRNAs
3. Immunological detection of muscarinic receptor subtype proteins (m1-m5) in rabbit peripheral tissues
4. Effect of scopolamine on the efflux of dopamine and its metabolites after clozapine, haloperidol or thioridazine
5. Antimuscarinic properties of neuroleptics and drug-induced Parkinsonism
6. Muscarinic antagonists attenuate the increase in accumbens and striatum dopamine metabolism produced by clozapine but not by haloperidol
7. Antipsychotic drugs and brain cholinergic receptors: affinity for muscarinic sites predicts extrapyramidal effects
8. Neuropharmacologic basis for clozapine's unique profile