Modulation of adriamycin® accumulation and efflux by flavonoids in HCT-15 colon cells. Activation of P-glycoprotein as a putative mechanism

Biochemical Pharmacology

Volumn 48, Issue 7, 1994, Pages 1437-1445

  Critchfield, James W ^a   Welsh, Clement J ^a   Phang, James M ^a   Chao Yeh, Grace ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Adriamycin; flavonoids; HCT 15 cells; P glycoprotein; quercetin

Indexed keywords

BUTYRIC ACID; BUTYRIC ACID DERIVATIVE; DOXORUBICIN; DRUG DERIVATIVE; FLAVONE DERIVATIVE; GALANGIN; GLYCOPROTEIN P; KAEMPFEROL; QUERCETIN; VERAPAMIL; VINBLASTINE; APIGENIN; CHALCONE DERIVATIVE; CHRYSIN; DIOSMIN; FISETIN; FLAVANOL DERIVATIVE; FLAVANONE DERIVATIVE; FLAVONE; FLAVONOID; FLAVONOL DERIVATIVE; ISOFLAVONE DERIVATIVE; MORIN; MYRICETIN; QUINIDINE; RADIOISOTOPE; RHOIFOLIN; RUTOSIDE; TAXIFOLIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CELL DIVISION; CELL LINE; CELL SURVIVAL; DIET; DOSE RESPONSE; DRUG EFFECT; DRUG INTERACTION; HUMAN; METABOLISM; STRUCTURE ACTIVITY RELATION; ANTINEOPLASTIC ACTIVITY; CANCER CELL CULTURE; COLON CARCINOMA; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACCUMULATION; DRUG ANTAGONISM; DRUG TRANSPORT; FOOD; HUMAN CELL; HYDROPHOBICITY; MULTIDRUG RESISTANCE; PHOTOAFFINITY LABELING; PLANT; PRIORITY JOURNAL;

BUTYRIC ACID; BUTYRIC ACIDS; CELL DIVISION; CELL LINE; CELL SURVIVAL; DIET; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; DRUG INTERACTIONS; FLAVONES; HUMAN; P-GLYCOPROTEIN; QUERCETIN; STRUCTURE-ACTIVITY RELATIONSHIP; VERAPAMIL; VINBLASTINE;

EID: 0028172728     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(94)90568-1     Document Type: Article

References (32)

1. P-glycoprotein: Multidrug-resistance and a superfamily of membrane-associated transport proteins
2. The multidrug resistance phenotype in human cancer
3. The function of Gp170, the multidrug-resistance gene product, in the brush border of rat intestinal mucosa
4. Possible link between the intrinsic drug resistance of colon tumors and a detoxification mechanism of intestinal cells.
5. Multidrug resistance gene family and chemical carcinogens
6. A new functional role for P-glycoprotein: Efflux pump for benzo(a)pyrene in human breast cancer MCF-7 cells
7. Flavonol-stimulated efflux of 7,12-dimethylbenz(a)anthracene in multidrug-resistant breast cancer cells
8. Effect of buthionine sulfoximine on toxicity of verapamil and doxorubicin to multidrug resistant cells and to mice
9. Modulation of resistance to alkylating agents in cancer cell by gossypol enantiomers
10. Physical-chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells
11. Chloroquine enhancement of anticancer drug cytotoxicity in multiple drug resistant human leukemic cells
12. Modulation of the expression of a multidrug resistance gene (mdr-1/P-glycoprotein) by differentiating agents
13. Expression of a drug resistance gene in human neuroblastoma cell lines: Modulation by retinoic acid-induced differentiation
14. Heat shock and arsenite increase expression of the multidrug resistance (MDR1) gene in human renal carcinoma cells
15. Heat-shock responsive elements in the induction of the multidrug resistance gene (MDR1)
16. The direct activation of human multidrug resistance gene (MDR1) by anticancer agents
17. Modulation of P-glycoprotein phosphorylation and drug transport by sodium butyrate
18. Flavonoids in the human diet
19. Flavonoids, a class of natural products of high pharmacologic potency
20. Inhibition of transformation in cultured rat tracheal epithelial cells by potential chemopreventive agents
21. New colorimetric cytotoxicity assay for anticancer-drug screening
22. Azidopine photoaffinity labeling of multidrug resistance-associated glycoproteins
23. Kaempferol stimulates the Pgp-mediated efflux of adriamycin (ADR) and dimethylbenzanthracene (DMBA) in multi-drug resistant MCF-7 cells by a redox-dependent mechanism
24. Establishment of multidrug resistant human colorectal carcinoma HCT-15 cell lines and their properties
25. Enhanced anti-proliferative action of busulphan by quercetin on the human leukaemia cell line K562
26. Enhancement of the antiproliferative activity of cis-diamminedichloroplatinum(II) by quercetin
27. The combination of quercetin and cytosine arabinose synergistically inhibits leukemic cell growth
28. Flavonoids as antioxidants: Determination of radical-scavenging efficiencies
29. Genistein, a specific inhibitor of tyrosine-specific protein kinases.
30. Protein kinase C inhibition by plant flavonoids. Kinetic mechanisms and structure-activity relationships
31. The inhibition of phosphatidylinositol 3-kinase by quercetin and analogs
32. Changing the American diet. Impact on cancer prevention policy recommendations and program implications for the American Cancer Society