1,25-dihydroxy-24-oxo-16ene-vitamin d3, a renal metabolite of the vitamin d analog 1,25-dihydroxy-16ene-vitamin d3, exerts immunosuppressive activity equal to its parent without causing hypercalcemia in vivo

Endocrinology

Volumn 135, Issue 6, 1994, Pages 2818-2821

  Lemire, Jacques M ^a   Archer, D Clay ^a   Reddy, C Satyanarayana ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b WOMEN AND INFANTS HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1ALPHA,3BETA,25 TRIHYDROXY 9,10 SECOCHOLESTA 5,7,10(19),16 TETRAEN 24 ONE; CALCITRIOL; CALCITRIOL DERIVATIVE; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ARTICLE; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; HYPERCALCEMIA; IMMUNOREGULATION; IMMUNOSUPPRESSIVE TREATMENT; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANIMAL; CALCITRIOL; CALCIUM; ENCEPHALOMYELITIS, EXPERIMENTAL AUTOIMMUNE; HYPERCALCEMIA; MICE; SUPPORT, U.S. GOV'T, P.H.S.; VITAMIN D;

EID: 0028172166     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/endo.135.6.7988477     Document Type: Article

References (14)

1. 3. J Cell Biochem 49:26-31.
2. Reichel H, Koe filer, H P, Tobler A, Norman AW 1987 la,25-Dihydroxyvitamin D3 inhibits y-interferon synthesis by normal human peripheral blood lymphocytes. Proc Natl Acad Sci USA 84:3385-3389.
3. 3suppresses human helper,'Inductor lymphocyte activity in vitro. J Immunol 34:2032-2035.
4. 3 prevents the in vivo induction of murine experimental autoimmune encephalomyelitis. J Clin Invest 87:1103-1107.
5. 3 attenuates the expression of experimental murine lupus of MRL/1 mice. Autoimmunity 12:143-148.
6. 3 on the induction of experimental autoimmune thyroiditis. Gin Immun Immunopath 54:53-63.
7. Mathieu C, Laureys J, Sobis H, Vandeputte M, Waer M, Bouillon R 1992 1,25-Dihyroxyvitamin-Dj prevents insulitis in NOD mice. Diabetes 41:1491-1495.
8. Lemire JM, Archer DC, Khulkami A, I nee A, Uskokovic MR, Stephkowski S 1992 The vitamin D3 analogue, 1.25- Dihyroxy-A16-cholecalciferol prolongs the survival of murine cardiac allografts. Transplantation 54:762-763.
9. 3 is a potent antileukemic agent with low potential to cause hypercalcemia. Leuk Res 18:453-463.
10. Reddy GS, Clark JW, Tsemg KY, Uskokovic MR, McLane JA 1993 Metabolism of l,25-(OH)216ene D3 in kidney: influence of structural modification of D-ring on side chain metabolism. Bioorg Med Chem Lett 3:1879-1884.
11. Tuohy VK, Lu Z, Sobel RA, Laursen RA, Lees MB 1989 Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice. J Immunol 142:1523-1527.
12. Uskokovic MR, Baggiolini E, Shiuey SJ, Iacobelli J, Hennessy B, Kiegiel J, Daniewski AR, Pizzolato G, Courtney LF, Horst RL 1991 The 16-ene analogs of 1.25- Dihydroxycholecalciferol. Synthesis and biological activity. In: Norman AW, Bouillon R, Thomasset M (eds.) Vitamin D. Gene regulation. Structure-function analysis and clinical application. Walter de Gruyter, Berlin, pp 139-145.
13. Lemire JM 1994 The role and mechanism of vitamin D analogs in immunosupression. In: Norman AW, Bouillon R, Thomasset M (eds.) Vitamin D. Vitamin D, a pluripotent steroid hormone: structural studies, molecular endocrinology and clinical applications. Walter de Gruyter, Berlin, (in press).
14. 3through C-24 oxidation pathway. Biochemistry 28:1763-1769.