The 1,25-dihydroxyvitamin D3 (VD) analogues MC903, EB1089 and KH1060 activate the VD receptor: Homodimers show higher ligand sensitivity than heterodimers with retinoid X receptors

Journal of Steroid Biochemistry and Molecular Biology

Volumn 51, Issue 3-4, 1994, Pages 137-142

  Carlberg, Carsten ^a   Mathiasen, Ida S ^b   Saurat, Jean Hilaire ^a   Binderup, Lise ^b  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^b LEO PHARMA A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIPOTRIOL; CALCITRIOL; CELL NUCLEUS RECEPTOR; LEXACALCITOL; OSTEOPONTIN; RETINOIC ACID; RETINOID X RECEPTOR; SEOCALCITOL; TRANSCRIPTION FACTOR; VITAMIN D RECEPTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; HUMAN; HUMAN CELL; NONHUMAN; RECEPTOR BINDING; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMAL; BASE SEQUENCE; CALCITRIOL; DNA; GENE EXPRESSION REGULATION; HUMAN; LIGANDS; MICE; MOLECULAR SEQUENCE DATA; RECEPTORS, CALCITRIOL; RECEPTORS, RETINOIC ACID; SUPPORT, NON-U.S. GOV'T; TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0028170822     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-0760(94)90086-8     Document Type: Article

References (30)

1. Vitamin D: New actions, new analogues, new therapeutic potential
2. 3 receptors: structure and function in transcription
3. The steroid and thyroid hormone receptor superfamily
4. 3 receptors: gene regulation and genetic circuitry
5. Transcriptional regulation by the nuclear receptor superfamily
6. Steroid and related receptors
7. A 55-kilodalton accessory factor facilitates vitamin D receptor DNA binding of rat
8. 3 receptor to its response elements
9. RXRβ: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements
10. 3 signalling
11. 3 receptors
12. 3 enhancement of mouse secreted phosphoprotein 1 (Spp-1 or osteopontin) gene expression
13. Two nuclear signalling pathways for vitamin D
14. 3
15. 1,25-dihydroxyvitamin D-responsive element and glucocorticoid repression in the osteocalcin gene
16. RXR-independent action of the receptors for thyroid hormone, retinoic acid, and vitamin D on inverted palindromes
17. Promiscuous liaisons
18. The mechanisms of vitamin D toxicity
19. Origin of the use of calcipotriol in psoriasis treatment
20. Immunological properties of vitamin D analogues and metabolites
21. EB1089, a novel vitamin D analogue, has strong antiproliferative and differentiation inducing effects on cancer cells
22. CAT construction with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements
23. Cell lines derived from late embryonic stages of Drosophila melanogaster
24. An improved CAT assay for promoter analysis in either transgenic mice or tissue culture cells
25. 9-cis retinoic acid is a natural antagonist for the retinoic acid receptor response pathway
26. Interaction between retinoic acid and vitamin D signalling pathways
27. RXR-dependent and RXR-independent transactivation by retinoic acid receptors
28. 3 analogues: a novel class of potent regulators of cell growth and immune responses
29. Specificity and flexibility of vitamin D signaling
30. 3-thyroid hormone receptor heterodimer polarity directs ligand sensitivity of transactivation