The 5-HT3 antagonist, BRL 46470 does not attenuate m-chlorophenylpiperazine (mCPP)-induced changes in human volunteers

Biological Psychiatry

Volumn 36, Issue 5, 1994, Pages 309-316

  Silverstone, Peter H ^a   Cowen, Philip J ^a  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

5 HT3 anxiety; BRL 46470; cortisol; m Chlorophenylpiperazine; prolactin

Indexed keywords

(3 CHLOROPHENYL)PIPERAZINE; 1-(3-CHLOROPHENYL)PIPERAZINE; ANXIOLYTIC AGENT; BICYCLO COMPOUND; FUSED HETEROCYCLIC RINGS; HYDROCORTISONE; INDOLE DERIVATIVE; PIPERAZINE DERIVATIVE; PROLACTIN; RICASETRON; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR;

ADOLESCENT; ADULT; ANXIETY; ARTICLE; BLOOD; BRAIN; CHEMICALLY INDUCED DISORDER; CLASSIFICATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; MIDDLE AGED; ORAL DRUG ADMINISTRATION; PANIC; PATHOPHYSIOLOGY; PHYSIOLOGY; PREMEDICATION; RANDOMIZED CONTROLLED TRIAL; HUMAN EXPERIMENT; NORMAL HUMAN; PRIORITY JOURNAL;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; ANTI-ANXIETY AGENTS; ANXIETY; BICYCLO COMPOUNDS; BICYCLO COMPOUNDS, HETEROCYCLIC; BRAIN; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; HUMANS; HYDROCORTISONE; INDOLES; INFUSIONS, INTRAVENOUS; MALE; MIDDLE AGED; PANIC; PIPERAZINES; PREMEDICATION; PROLACTIN; RECEPTORS, SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS;

EID: 0028169962     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-3223(94)90628-9     Document Type: Article

References (35)

1. 3 receptor antagonists: an overview of their present status and future potential in cancer therapy-induced emesis
2. Neuroendocrine and behavioural effects of m-chlorophenylpiperazine administration in Rhesus monkeys
3. Different serotonin receptors mediate blood-pressure, heart rate, plasma catecholamine and prolactin responses to m-chlorophenylpiperazine in conscious rats
4. Serotonin agonists cause parallel activation of the sympathoadreno-medullary system and the hypothalamic-pituitary-adrenocortical axis in conscious rats
5. 3 receptor antagonists, on cognition in rodents and primates
6. 3 receptor antagonist
7. 3 receptor antagonist with anxiolytic-like activities
8. ACUTE ADMINISTRATION OF ONDANSETRON AND M-CPP IN HEALTHY VOLUNTEERS: BEHAVIORAL AND BIOLOGICAL RESULTS
9. Serotonin function in anxiety II: effects of the serotonin agonist MCPP in panic disorder patients and healthy subjects
10. Serotonin function in obsessive-compulsive disorder: a comparison of the effects of tryptophan and m-chlorophenylpiperazine in patients and healthy subjects
11. Memory enhancing effects of granisetron (BRL 43694) in a passive avoidance task
12. 3 receptors
13. Serotonin receptor subtypes: implications for psychopharmacology
14. Determination of m-chlorophenylpiperazine in plasma by high-performance liquid chromatography with coulometric detection
15. 3 receptor antagonist, BRL 46470, on the social behaviour or mice
16. 1-(m-chlorophenyl)piperazine (mCPP) interactions with neurotransmittter receptors in the human brain
17. Serotonergic function in obsessive-compulsive disorder: behavioural and neuroendocrine responses to oral m-chlorphenylpiperazine and fenfluramine in patients and healthy volunteers
18. 1 recognition sites
19. 1C receptors
20. 1C receptor antagonists
21. m-Chlorophenylpiperazine as a probe of serotonin function
22. Serotonin and anxiety revisited
23. Effects of serotonin antagonists on m-chlorophenylpiperazine-mediated responses in normal subjects
24. Effects of m-chlorophenylpiperazine in normal subjects: a dose-response study
25. A dose-response study of intravenous m-chlorophenylpiperazine in normal subjects
26. A preliminary study of the effects of intravenous m-chlorophenylpiperazine, a serotonin agonist, in elderly subjects
27. Neuroendocrine effects of m-chlorphenylpiperazine, a serotonin agonist, in humans
28. A new postsynaptic serotonin receptor agonist suitable for studies in humans
29. Further studies of the putative serotonin agonist, m-chlorophenylpiperazine: Evidence for a serotonin receptor mediated mechanism of action in humans
30. Comparative anxiogenic, neuroendocrine, and other physiologic effects of m-chlorphenylpiperazine given intravenously or orally to healthy volunteers
31. The anxiolytic activity of BRL 46470 in the cynomolgus monkey
32. Effects of ritanserin on the behavioural, neuroendocrine, and cardiovascular responses to meta-chlorophenylpiperazine in healthy human subjects
33. Serotonic responsivity in obsessive-compulsive disorder: comparison of patients and healthy controls