IFN-γ receptor-deficient mice generate antiviral Th1-characteristic cytokine profiles but altered antibody responses

Journal of Immunology

Volumn 153, Issue 5, 1994, Pages 2029-2037

  Schijns, Virgil E C J ^a   Haagmans, Bart L ^a   Rijke, Eric O ^b   Huang, Sui ^c   Aguet, Michel ^c   Horzinek, Marian C ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b INTERVET INTERNATIONAL BV   (Netherlands)

^c UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CONCANAVALIN A; GAMMA INTERFERON; INTERFERON RECEPTOR; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; VIRUS ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ANTIBODY TITER; ANTIGEN EXPRESSION; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; GENE TARGETING; IMMUNE DEFICIENCY; IMMUNOHISTOCHEMISTRY; IMMUNOMODULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PSEUDORABIES HERPETOVIRUS; SPLEEN; VIRUS ATTENUATION;

ANIMALS; ANTIBODIES, VIRAL; ANTIBODY FORMATION; CYTOKINES; FEMALE; HERPESVIRUS 1, SUID; INTERFERON TYPE II; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COOPERATION; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PSEUDORABIES; SPLEEN; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 0028169445     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. Trinchieri, G., and B. Perussia. 1985. Immune Interferon: a pleiotropic lymphokine with multiple effects. Immunol. Today 6:131.
2. Huang, S., W. Hendriks, A. Althage, S. Hemmi, H. Bluethmann, R. Kamijo, J. Vilček, R. M. Zinkernagel, and M. Aguet. 1993. Immune response in mice lacking the interferon-γ receptor. Science 259:1742.
3. Stanton, G. J., C. Jordan, A. Hart, H. Heard, M. P. Langford, and S. Baron. 1987. Nondetectable levels of interferon-gamma is a critical host defense during the first day of herpes simplex virus infection. Microb. Pathog. 3:179.
4. Karupiah, G., T. N. Fredrickson, K. L. Holmes, L. H. Khairallah, and R. M. L. Buller. 1993. Importance of interferons in recovery from mousepox. J. Virol. 67:4214.
5. Smith, A. L., S. W. Barthold, M. S. De Souza, and K. Bottomly. 1991. The role of interferon in infection of susceptible mice with murine coronavirus MHV-JHM. Arch. Virol. 121:89.
6. Lučin, P., I. Pavić, B. Polić, S. Jonić, and U. H. Koszinowski. 1992. Gamma-interferon-dependent clearance of cytomegalovirus infection in salivary glands. J. Virol. 66: 1977.
7. Leist, T. P., M. Eppler, and R. M. Zinkernagel. 1989. Enhanced virus replication and inhibition of lymphocytic choriomeningitis disease in anti-gamma-interferon-treated mice. J. Virol. 63:2813.
8. Wille, A., A. Gessner, H. Lother, and F. Lehmann-Grube. 1989. Mechanism of recovery from acute virus infection. VIII. Treatment of lymphocytic choriomeningitis virus-infected mice with anti-interferon-γ monoclonal Ab blocks generation of virus-specific cytotoxic T lymphocytes and virus elimination. Eur. J. Immunol. 19:1283.
9. Klavinskis, L. S., R. Geckeler, and M. B. A. Oldstone. 1989. Cytotoxic T lymphocyte control of acute lymphocytic choriomeningitis virus infection: interferon-γ, but not tumour necrosis factor a, displays antiviral activity in vivo. J. Gen. Virol. 70:3317.
10. Coutelier, J.-p., J. T. M. van der Logt, F. W. A. Heessen, G. Warmer, and J. Van Snick. 1987. IgG2a restriction of murine antibodies elicited by viral infections. J. Exp. Med. 165:64.
11. Coutelier, J.-p., P. G. Coulie, P. Wauters, H. Heremans, and J. T. M. van der Logt. 1990. In vivo polyclonal B-lymphocyte activation elicited by murine viruses. J. Virol. 64:5383.
12. Snapper, C. M., and W. E. Paul. 1987. Interferon-γ and B cell stimulatory factor-1 reciprocally regulate Ig isotype production. Science 236:944.
13. Finkelman, F., I. M. Katona, T. R. Mosmann, and R. L. Coffman. 1988. IFN-γ regulates the isotypes of Ig secreted during in vivo humoral immune responses. J. Immunol. 140:1022.
14. Graham, M. B., D. Dalton, D. Giltinan, V. L. Braciale, T. A. Stewart, and T. J. Braciale. 1993. Response to influenza infection in mice with a targeted disruption in the interferon-γ gene. J. Exp. Med. 178:1725.
15. Scott, P., and S. H. E. Kaufman. 1991. The role of T-cell subsets and cytokines in the regulation of infection. Immunol. Today 12:346.
16. Maggi, E., P. Parronchi, R. Manetti, C. Simonelli, M.-p. Piccinni, F. S. Rigiu, M. De Carli, M. Ricci, and S. Romangnani. 1992. Reciprocal regulatory effects of IFN-γ and IL-4 on the in vitro development of human Th1 and Th2 clones. J. Immunol. 148:2142.
17. Gajewski, T. F., and F. W. Fitch. 1988. Anti-proliferative effect of IFN-γ in immune regulation. I. IFN-γ inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones. J. Immunol. 140:4245.
18. Scott, P. 1991. IFN-γ modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasis. J. Immunol. 147:3149.
19. + αβ-TCR transgenic T cells is macrophage dependent. Int. Immunol. 5:371.
20. Buchmeier, N. A., and R. D. Schreiber. 1985. Requirement for endogenous interferon-γ production for resolution of Listeria monocytogenes infection. Proc. Natl. Acad. Sci. USA 82:7404.
21. Dalton, D. K., S. Pitts-Meek, S. Keshav, I. S. Figari, A. Bradley, and T. A. Stewart. 1993. Multiple defects of immune cell function in mice with disrupted interferon-γ genes. Science 259:1739.
22. + effector cells default to the Th2 pathway in interferon-γ-deficient mice infected with Leishmania major. J. Exp. Med. 179:1367.
23. Van Oirschot, J. T., R. J. M. Moorman, A. J. M. Berns, and A. L. J. Gielkens. 1991. Efficacy of pseudorabies virus vaccine based on deletion mutant strain 783 that does not express thymidine kinase and glycoprotein I. Am. J. Vet. Res. 52:1056.
24. Fuchs, W., H.-j. Rziha, N. Lukacs, I. Braunschweiger, N. Visser, D. Lütticken, C. S. Schreurs, H.-j. Thiel, and T. C. Mettenleiter. 1990. Pseudorabies virus glycoprotein gI: in vitro and in vivo analysis of immunorelevant epitopes. J. Gen. Virol. 71:1141.
25. Van der Meide, P. H., A. H. Borman, H. G. Beljaars, M. A. Dubbeld, C. A. D. Botman, and H. Schellekens. 1989. Isolation and characterization of monoclonal antibodies directed to rat interferon-γ. Lymphokine Res. 8:439.
26. Gillis, S., M. M. Ferm, W. Ou, and K. A. Smith. 1978. T cell growth factor: parameters of production and qualitative microassay for activity. J. Immunol. 120:2027.
27. Van den Eertwegh, A. J. M., H. J. Fasbender, M. M. Schellekens, A. Van Oudenaren, W. J. A. Boersma, and E. Claassen. 1991. In vivo kinetics and characterization of IFN-γ producing cells during a thymus independent immune response. J. Immunol. 147:439.
28. Zuckermann, F. A., L. Zsak, T. C. Mettenleiter, and T. Ben-Porat. 1990. Pseudorabies virus glycoprotein gIII is a major target antigen for murine and swine virus-specific cytotoxic T lymphocytes. J. Virol. 64:802.
29. Murray, J. S., J. Madri, T. Pasqualini, and K. Bottomly. 1993. Functional CD4 T cell subset interplay in an intact immune system. J. Immunol. 150:4270.
30. Snapper, C. M., and J. J. Mond. 1993. Towards a comprehensive view of immunoglobulin class switching. Immunol. Today 14:15.
31. Jacob, C. O., P. H. Van der Meide, and H. O. McDevitt. 1987. In vivo treatment of (NZB × NZW)F1 lupus-like nephritis with monoclonal Ab to interferon-γ. J. Exp. Med. 166:798.
32. + cells, and antibodies required for immunity to malaria sporozoites. Nature 330:664.
33. Marchioli, C., R. J. Janecy, J. G. Timmins, L. E. Post, B. R. Young, and D. A. Povendo. 1988. Protection of mice and swine from pseudorabies virus-induced mortality by administration of pseudorabies virus-specific mouse monoclonal antibodies. Am. J. Vet. Res. 49:860.
34. Flynn, J. A., J. Chan, K. J. Triebold, D. K. Dalton, T. A. Stewart, and B. R. Bloom. 1993. An essential role for interferon-γ in resistance to Mycobacterium tuberculosis infection. J. Exp. Med. 178: 2249-2254.
35. + T cells through IL-12 produced by Listeria-mduced macrophages. Science 260:547.
36. Manetti, R., P. Parronchi, G. Giudizi, M.-p. Piccinni, E. Maggi, G. Trinchieri, and S. Romagnani. 1993. Natural killer cell stimulatory factor (interleukin 12, IL-12) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of 1L-4-producing Th cells. J. Exp. Med. 177:1199.
37. + T cells to enhance priming for interferon-γ production and diminishes interleukin 4 inhibition of such priming. Proc. Natl. Acad. Sci. USA 90:10188.
38. McKnight, A. J., G. J. Zimmer, I. Fogelman, S. F. Wolf, and A. K. Abbas. 1994. Effects of IL-12 on helper T cell-dependent immune responses in vivo. J. Immunol. 152:2172.
39. Liew, F. Y., Y. Li, D. M. Yang, A. Severn, and F. E. G. Cox. 1991. TNF-α reverses the disease-exacerbating effect of subcutaneous immunization against murine cutaneous leishmaniasis. Immunology 74: 304.
40. Romagnani, S. 1992. Induction of Th1 and Th2 responses: a key role for the 'natural' immune response? Immunol. Today 13:379.
41. Finkelman, F. D., A. Svetic, I. Gresser, C. Snapper, J. Holmes, P. P. Trotta, I. M. Katona, and W. G. Gause. 1991. Regulation by interferon-α of immunoglobulin isotype selection and lymphokine production. J. Exp. Med. 174:1179.
42. De Maeyer, E., M.-c. Hoyez, J. De Maeyer-Guignard, and D. W. Bailey. 1979. Effect of mouse genotype on Interferon production. III. Expression of IF-1 by peritoneal macrophages. Immunogenetics 8:257.
43. + T cells. J. Immunol. 146:577.
44. Noble, A., D. Z. Staynov, and D. M. Kemey. 1993. Generation of rat Th-2-like cells in vitro is interleukin-4-dependent and inhibited by interferon-γ. Immunology 79:562.
45. Schijns, V. E. C. J., T. H. Borman, H. Schellekens, and M. C. Horzinek. 1988. Antiviral activity of recombinant rat interferon-gamma in immunologically impaired and immunosuppressed rats. J. Gen. Virol. 69:1979.
46. Schijns, V. E. C. J., R. Van der Neut, B. L. Haagmans, D. R. Bar, H. Schellekens, and M. C. Horzinek. 1991. Tumour necrosis factor-α, interferon-γ and interferon-β exert antiviral activity in nervous tissue cells. J. Gen. Virol. 72:809.
47. Gajewski, T. F., and F. W. Fitch. 1988. Anti-proliferative effect of IFN-γ in immune regulation. I. IFN-γ inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones. J. Immunol. 140:4245.
48. Liu, Y., and C. A. Janeway, Jr. 1990. Interferon-γ plays a critical role in induced cell death of effector T cell: a possible third mechanism of self-tolerance. J. Exp. Med. 172:1735.
49. Leibson, H. J., M. Gefter, A. Zlotnik, P. Marrack, and J. W. Kappler. 1984. Role of γ-interferon in antibody-producing responses. Nature 309:799.
50. Sidman, C. L., J. D. Marshall, L. D. Shultz, P. W. Gray, and H. M. Johnson. 1984. γ-Interferon is one of several direct B cell-maturing lymphokines. Nature 309:801.
51. Schijns, V. E. C. J., I. J. Th. M. Claassen, A. A. Vermeulen, M. C. Horzinek, and A. D. M. E. Osterhaus. 1994. Modulation of antiviral immune responses by exogenous cytokines: effects of tumour necrosis factor-α, interleukin-1α, interleukin-2 and interferon-γ on the immunogenicity of an inactivated rabies virus vaccine. J. Gen. Virol. 75:55.
52. Snapper, C. M., T. M. Intyre, R. Mandler, L. M. Pecanha, F. D. Finkelman, A. Lees, and J. J. Mond. 1992. Induction of IgG3 secretion by interferon-γ: a model for T cell-independent class switching in response to T cell-independent type 2 antigens. J. Exp. Med. 175: 1367.