Three NF-κB binding sites in the human E-selectin gene required for maximal tumor necrosis factor alpha-induced expression

Molecular and Cellular Biology

Volumn 14, Issue 9, 1994, Pages 5820-5831

  Schindler, Ulrike ^a   Baichwal, Vijay R ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERLEUKIN 1; RECOMBINANT PROTEIN; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BINDING SITE; CONTROLLED STUDY; ENDOTHELIUM CELL; GENE EXPRESSION REGULATION; GENE INDUCTION; HUMAN; HUMAN CELL; LEUKOCYTE ADHERENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; TRANSCRIPTION REGULATION; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

EID: 0028168798     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/mcb.14.9.5820     Document Type: Article

References (40)

1. Baeuerle, P. A., and T. Henkel. 1994. Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12:141-179.
2. Becker-Andre, M., R. Hooft van Huijsduijnen, C. Losberger, J. Whelan, and J. F. DeLamarter. 1992. Murine endothelial leukocyte-adhesion molecule 1 is a close structural and functional homologue of the human protein. Eur. J. Biochem. 206:401-411.
3. Beg, A. A., and A. S. Baldwin, Jr. 1993. The IkB proteins: multifunctional regulators of Rel/NF-κB transcription factors. Genes Dev. 7:2064-2070.
4. Beg, A. A., T. S. Finco, P. V. Nantermet, and A. S. Baldwin, Jr. 1993. Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of IκBα: a mechanism for NF-κB activation. Mol. Cell. Biol. 13:3301-3310.
5. Bevilacqua, M. P., S. Stengelin, M. A. Gimbrone, Jr., and B. Seed. 1989. Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins. Science 243:1160-1165.
6. Blank, V., P. Kourilsky, and A. Israel. 1992. NF-κB and related proteins: Rel/dorsal homologies meet ankyrin-like repeats. Trends Biochem. Sci. 17:135-140.
7. Butcher, E. C. 1991. Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. Cell 67:1033-1036.
8. Collins, T., H. J. Palmer, M. Z. Whitley, A. S. Neish, and A. J. Williams. 1993. A common theme in endothelial activation. Insights from the structural analysis of the genes for E-selectin and VCAM-1. Trends Cardiovasc. Med. 3:92-97.
9. Collins, T., A. Williams, G. I. Johnston, J. Kim, R. Eddy, T. Shows, M. A. Gimbrone, Jr., and M. P. Bevilacqa. 1991. Structure and chromosomal location of the gene for endothelial-leukocyte adhesion molecule 1. J. Biol. Chem. 266:2466-2473.
10. Cotran, R. S., M. A. Gimbrone, Jr., M. P. Bevilacqua, D. L. Mendrick, and J. S. Pober. 1986. Induction and detection of a human endothelial activation antigen in vivo. J. Exp. Med. 164: 661-668.
11. Du, W., D. Thanos, and T. Maniatis. 1993. Mechanisms of transcriptional synergism between distinct virus-inducible enhancer elements. Cell 74:887-898.
12. Elgin, S. C. R. 1988. The formation and function of DNase I hypersensitive sites in the process of gene activation. J. Biol. Chem. 263:19259-19262.
13. Enver, T., A. C. Brewer, and R. K. Patient. 1985. Simian virus 40 mediated cis induction of the Xenopus β-globin DNaseI hypersensitive site. Nature (London) 318:680-683.
14. Ghersa, P., R. Hooft van Huijsduijnen, J. Whelan, and J. F. DeLamarter. 1992. Labile proteins play a dual role in the control of endothelial leukocyte adhesion molecule-1 (ELAM-1) gene regulation. J. Biol. Chem. 267:19226-19232.
15. Gilmore, T. D., and P. J. Morin. 1993. The IkB proteins: members of a multifunctional family. Trends Genet. 9:427-433.
16. Grilli, M., J. S. Chiu, and M. J. Lenardo. 1993. NF-κB and Rel - participants in a multiform transcriptional regulatory system. Int. Rev. Cytol. 143:1-63.
17. Gross, D. S., and W. T. Garrard. 1988. Nuclease hypersensitive sites in chromatin. Annu. Rev. Biochem. 57:159-197.
18. Hai, T., F. Liu, W. J. Coukos, and M. R. Green. 1989. Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers. Genes Dev. 3:2083-2090.
19. Hooft van Huijsduijnen, R., J. Whelan, R. Pescini, M. Becker-Andre, A.-M. Schenk, and J. F. DeLamarter. 1992. A T-cell enhancer cooperates with NF-κB to yield cytokine induction of E-selectin gene transcription in endothelial cells. J. Biol. Chem. 267:22385-22391.
20. Hou, J., V. Baichwal, and Z. Cao. Proc. Natl. Acad. Sci. USA, in press.
21. Iademarco, M. F., J. J. McQuillan, G. D. Rosen, and D. C. Dean. 1992. Characterization of the promoter for vascular cell adhesion molecule-1 (VCAM-1) J. Biol. Chem. 267:16323-16329.
22. Karim, F. D., L. D. Urness, C. S. Thummel, M. J. Klemsz, S. R. McKercher, A. Celada, C. Van Beveren, R. A. Maki, C. V. Gunther, J. A. Nye, and B. J. Graves. 1990. The ETS-domain: a new DNA-binding motif that recognizes a purine-rich core DNA sequence. Genes Dev. 4:1451-1453.
23. Kaszubska, W., R. Hooft van Huijsduijnen, P. Ghersa, A.-M. DeRaemy-Schenk, B. P. C. Chen, T. Hai, J. F. DeLamarter, and J. Whelan. 1993. Cyclic AMP-independent ATF family members interact with NF-κB and function in the activation of the E-selectin promoter in response to cytokines. Mol. Cell. Biol. 13:7180-7190.
24. Kunsch, C., S. M. Ruben, and C. A. Rosen. 1992. Selection of optimal kB/Rel DNA-binding motifs: interaction of both subunits of NF-κB with DNA is required for transcriptional activation. Mol. Cell. Biol. 12:4412-4421.
25. Liou, H.-C., and D. Baltimore. 1993. Regulation of the NF-κB/rel transcription factor and IkB inhibitor system. Curr. Opin. Cell Biol. 5:477-487.
26. Maxam, A. M., and W. Gilbert. 1980. Sequencing end-labeled DNA with base-specific chemical cleavages. Methods Enzymol. 65:499-560.
27. McEver, R. P. 1991. Selectins: novel receptors that mediate leukocyte adhesion during inflammation. Thromb. Haemostasis 65:223-228.
28. Montgomery, K. F., L. Osborn, C. Hession, R. Tizard, D. Goff, C. Vassallo, P. I. Tarr, K. Bomsztyk, R. Lobb, J. M. Harlan, and T. H. Pohlman. 1991. Activation of endothelial-leukocyte adhesion molecule 1 (ELAM-1) gene transcription. Proc. Natl. Acad. Sci. USA 88:6523-6527.
29. Narayanan, R., K. A. Higgins, J. R. Perez, T. A. Coleman, and C. A. Rosen. 1993. Evidence for differential functions of the p50 and p65 subunits of NF-κB with a cell adhesion model. Mol. Cell. Biol. 13:3802-3810.
30. Neish, A. S., A. J. Williams, H. J. Palmer, M. Z. Whitley, and T. Collins. 1992. Functional analysis of the human vascular cell adhesion molecule 1 promoter. J. Exp. Med. 176:1583-1593.
31. Osborn, L. 1990. Leukocyte adhesion to endothelium in inflammation. Cell 62:3-6.
32. Osborn, L., C. Hession, R. Tizard, C. Vassallo, S. Luhowskyj, G. Chi-Rosso, and R. Lobb. 1989. Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes. Cell 59:1203.
33. Osborn, L., S. Kunkel, and G. J. Nabel. 1989. Tumor necrosis factor a and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor κB. Proc. Natl. Acad. Sci. USA 86:2336-2340.
34. Perkin, N. D., R. M. Schmid, C. S. Duckett, K. Leung, N. R. Rice, and G. J. Nabel. 1992. Distinct combinations of NF-κB subunits determine the specificity of transcriptional activation. Proc. Natl. Acad. Sci. USA 89:1529-1533.
35. Pober, J. S., M. A. Gimbrone, Jr., L. A. Lapierre, D. L. Mendrick, W. Fiers, R. Rothlein, and T. A. Springer. 1986. Overlapping patterns of activation of human endothelial cells by interleukin-1, tumor necrosis factor, and immune interferon. J. Immunol. 137: 1893.
36. Schindler, U., and V. R. Baichwal. Unpublished data.
37. Shu, H. B., A. B. Agranoff, E. G. Nabel, K. Leung, C. S. Duckett, A. S. Neish, T. Collins, and G. J. Nabel. 1993. Differential regulation of vascular cell adhesion molecule 1 gene expression by specific NF-κB subunits in endothelial and epithelial cells. Mol. Cell. Biol. 13:6283-6289.
38. Thompson, C. C., T. A. Brown, and S. L. McKnight. 1991. Convergence of Ets- and Notch-related structural motifs in a heteromeric DNA binding complex. Science 253:762-768.
39. Tjian, R., and T. Maniatis. 1994. Transcriptional activation: a complex puzzle with few easy pieces. Cell 77:5-8.
40. Whelan, J., P. Ghersa, R. Hooft van Huijsduijnen, J. Gray, G. Chandra, F. Talabot, and J. F. DeLamarter. 1991. An NF-κB-like factor is essential but not sufficient for cytokine induction of endothelial leukocyte adhesion molecule 1 (ELAM-1) gene transcription. Nucleic Acids Res. 19:2645-2663.