Effects of GABAA receptors activation on brain glucose metabolism in normal subjects and temporal lobe epilepsy (TLE) patients. A positron emission tomography (PET) study Part II: The focal hypometabolism is reactive to GABAA agonist administration in TLE

Epilepsy Research

Volumn 19, Issue 1, 1994, Pages 55-62

  Peyron, R ^a   Cinotti, L ^a   Le Bars, D ^a   Garcia Larrea, L ^a   Galy, G ^a   Landais, P ^a   Millet, P ^a   Lavenne, F ^a   Froment, J C ^a   Krogsgaard Larsen, P ^b   Mauguiere F ^a  

^a Centre d'Exploration et de Recherche Médicale Par Emission de Positons Imagerie du Vivant   (France)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Glucose metabolism; Inhibitory neurotransmitter; Positron emission tomography; Aminobutyric acid (GABA)

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; GABOXADOL; 4,5,6,7-TETRAHYDROISOXAZOLO(5,4-C)PYRIDIN-3-OL; DIAGNOSTIC AGENT; FLUORINE; GLUCOSE; ISOXAZOLE DERIVATIVE; RECEPTORS, GABA A;

ADULT; ARTICLE; BRAIN METABOLISM; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; TEMPORAL LOBE EPILEPSY; BRAIN; COMPUTER ASSISTED EMISSION TOMOGRAPHY; DRUG EFFECT; METABOLISM; RADIOASSAY; REFERENCE VALUE; SCINTISCANNING;

ADULT; BRAIN; EPILEPSY, TEMPORAL LOBE; FEMALE; FLUORINE RADIOISOTOPES; GABA AGONISTS; GLUCOSE; HUMAN; ISOXAZOLES; MALE; MIDDLE AGE; RADIOLIGAND ASSAY; RECEPTORS, GABA-A; REFERENCE VALUES; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0028168560     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/0920-1211(94)90088-4     Document Type: Article

References (43)

1. Topography of glucose hypometabolism in epilepsy of mesial temporal origin
2. Temporal lobe volumetric cell densities in temporal lobe epilepsy
3. Distribution of pyramidal cell density and hyperexcitability in the epileptic human hippocampal formation
4. Glutamate decar☐ylase-immunoreactive neurons are preserved in human epileptic hippocampus
5. Neurotransmitter, receptor and biochemical changes in monkey cortical epileptic foci
6. Pathological findings underlying focal temporal lobe hypometabolism in partial epilepsy
7. Comparative localization of epileptic foci in partial epilepsy by PCT and EEG
8. Interictal cerebral glucose metabolism in partial epilepsy and its relation to EEG changes
9. Seizure protection and increased nerve-terminal GABA: Delayed effects of GABA transaminase inhibition
10. Extratemporal cortical hypometabolism on interictal PET in complex partial seizures
11. Seizures induced by alylglycine, 3-mercaptopropionic acid and 4-deoxypyridoxin in mice and photosensitive baboons, and different modes of inhibition of cerebral glutamic acid decar☐ylase
12. Gammaaminobutyric acid and benzodiazepine binding sites in audiogenie seizure-susceptible mice
13. Cerebrospinal fluid GABA levels in various neurological and psychiatric diseases
14. Abortive amygdaloid kindled seizures following microinjection of gamma-vinyl-GABA in the vicinity of substantia nigra in rats
15. Alteration of GABA-mediated synaptic transmission in human epilepsy
16. Biochemical evidence for dysfunction of GABA neurons in human epilepsy
17. Biochemical evidence for the alterations of GABA-mediated synaptic transmission in pathological brain tissue (stereo EEG or morphological definition) from epileptic patients
18. Valproic acid increases gamma-amino-butyric acid in CSF of epileptic children
19. Cerebrospinal fluid gammaaminobutyric acid levels in children with different types of epilepsy: Effect of anticonvulsant treatment
20. Antiepileptic drug actions
21. Levels of gamma-aminobutyric acid in cerebrospinal fluid in various neurologic disorders
22. Gamma-aminobutyric acid and the search for new anticonvulsant drugs
23. Convulsant drugs, anticonvulsants and GABA-mediated neuronal inhibition
24. Effects of gamma-acetylenic GABA and gamma-vinyl GABA on metrazol-activated and kindled seizures
25. Role of the gamma-aminobutyric acid receptor—ionophore complex in seizure disorders
26. Benzodiazepine/gamma-aminobutyric acid receptor deficit in the midbrain of the seizure-susceptible gerbil
27. Amino acid abnormalities in epileptogenic foci
28. Amino acids in human epileptogenic foci
29. Effect of vigabatrin (gamma-vinyl GABA) on amino acid levels in CSF of epileptic patients
30. Mechanisms of action of new antiepileptic drugs
31. Inhibitory, GABAergic nerve terminals decrease at sites of focal epilepsy
32. Gamma-aminobutyric acid concentration, l-glutamate-1-decar☐ylase activity, and properties of the gamma-aminobutyric acid postsynaptic receptor in cobalt epilepsy in the rat
33. Metabolic patterns associated with non-specific magnetic resonance imaging abnormalities in temporal lobe epilepsy
34. Differences between lateral and mesial temporal metabolism interictally in epilepsy of mesial temporal origin
35. Comparison of [11C]flumazenil and [18F]FDG as PET markers of epileptic foci
36. In vivo demonstration of reduced benzodiazepine receptor binding in human epileptic foci
37. Cortical benzodiazepine receptor binding in patients with generalized and partial epilepsy
38. Combined depth and subdural electrode investigation in uncontrolled epilepsy
39. The role of positron emission tomography in the evaluation of seizure disorders
40. Pathology of temporal lobe foci: Correlation with CT, MRI, and PET
41. acid content of epileptogenic human brain: Focal versus surrounding regions
42. Selective amygdalo-hippocampectomy for temporal lobe epilepsy
43. Low cerebrospinal fluid gamma-aminobutyric acid content in seizure patients