Evaluation of a transgenic mouse model for alpha‐1‐antitrypsin (AAT) related liver disease

Annals of Human Genetics

Volumn 58, Issue 4, 1994, Pages 305-320

  ALI, R ^a   PERFUMO, S ^b   ROCCA, C della ^b   AMICONE, L ^b   POZZI, L ^b   McCULLAGH, P ^c   MILLWARD SADLER H ^c   EDWARDS, Y ^a   POVEY, S ^a   TRIPODI, M ^b  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

^b POLICLINICO UMBERTO I   (Italy)

^c SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ANTITRYPSIN; FATTY ACID BINDING PROTEIN; M PROTEIN; MESSENGER RNA; MUTANT PROTEIN; PROTEINASE INHIBITOR; RECOMBINANT DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; EMBRYO; ENZYME BLOOD LEVEL; ENZYME SYNTHESIS; HUMAN; IMMUNOCYTOCHEMISTRY; ISOELECTRIC FOCUSING; LIVER CELL; LIVER DISEASE; LIVER HISTOLOGY; LIVER LEVEL; LIVER NECROSIS; MOUSE; NEWBORN DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; TRANSGENIC MOUSE;

ALPHA 1-ANTITRYPSIN; ANIMAL; ANIMALS, NEWBORN; BLOTTING, NORTHERN; COMPARATIVE STUDY; DISEASE MODELS, ANIMAL; EVALUATION STUDIES; GENE EXPRESSION; HUMAN; IMMUNOENZYME TECHNIQUES; LIVER; LIVER DISEASES; MICE; MICE, INBRED STRAINS; MICE, TRANSGENIC; MUTATION; SUPPORT, NON-U.S. GOV'T;

EID: 0028150915     PISSN: 00034800     EISSN: 14691809     Source Type: Journal    
DOI: 10.1111/j.1469-1809.1994.tb00728.x     Document Type: Article

References (30)

1. PCR as a rapid screening method for transgenic mice.
2. Prenatal diagnosis of alpha‐1‐antitrypsin deficiency by PCR of linked polymorphisms: a study of 17 cases.
3. Molecular basis of alpha‐1‐anatitrypsin deficiency.
4. The effect of alpha‐1‐antitrypsin on the proliferative response of human peripheral blood lymphocytes.
5. 1‐antitrypsin causes liver damage in transgenic mice.
6. 1‐antitrypsin.
7. 1‐antitrypsin deficiency and estimates for fetal risk for disease.
8. DNA restriction fragments associated with alpha‐1‐antitrypsin indicate a single origin for deficiency allele PI Z.
9. 1‐antitrypsin deficiency.
10. 1‐antitrypsin: a transgenic mouse model.
11. Neonatal growth delay in alpha‐1‐antitrypsin disease.
12. 1‐antitrypsin.
13. Reliable classification of six PiM subtypes by separator isoelectric focusing.
14. 1‐Antitrypsin deficiency.
15. Different evolution of emphysema in two strains of mice with similar serum antielastase deficits.
16. 1‐antitrypsin liver disease in a transgenic mouse model.
17. 1‐antitrypsin in transgenic mice.
18. 1‐antitrypsin accumulation in the liver.
19. Lymphocyte cytoxicity to autologous hepatocytes in alpha‐1‐antitrypsin deficiency.
20. 1‐Antitrypsin deficiency in liver disease
21. 1‐antitrypsin deficiency and liver disease.
22. 1‐antitrypsin deficiency in relation to neonatal liver disease.
23. The human alpha‐1‐antitrypsin gene is efficiently expressed from two tissue‐specific promoters in transgenic mice.
24. Cytotoxicity to isolated rabbit hepatocytes by lymphocytes from children with liver disease.
25. 1‐antitrypsin deficient children.
26. Generation of small mutation in large genomic fragments by homologous recombination: description of the technique and examples of its use.
27. tun) at the PI locus.
28. Variation in alpha‐1‐antitrypsin phenotypes associated with penicillamine therapy.