Synthesis and Evaluation of the Anti-HIV Activity of Aza and Deaza Analogs of IsoddA and Their Phosphates as Prodrugs

Journal of Medicinal Chemistry

Volumn 37, Issue 21, 1994, Pages 3534-3541

  Franchetti, Palmarisa ^a   Cappellacci, Loredana ^a   Grifantini, Mario ^a   Messini, Lea ^a   Sheikha, Ghassan Abu ^a   Loi, Anna Giulia ^b   Tramontano, Enzo ^b   Antonella De, Montis ^b   Spiga, Maria Grazia ^b   La Colla, Paolo ^b  

^a UNIVERSITY OF CAMERINO   (Italy)

^b UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2',3' DIDEOXYADENOSINE; [4 (4 AMINO 1H IMIDAZO[4,5 C]PYRIDIN 1 YL)TETRAHYDROFURAN 2 YL]METHANOL; [4 (4 AMINO[1,2,3]TRIAZOLO[4,5 C]PYRIDIN 1 YL)TETRAHYDROFURAN 2 YL]METHANOL; [4 (7 AMINO[1,2,3]TRIAZOLO[4,5 B]PYRIDIN 3 YL)TETRAHYDROFURAN 2 YL]METHANOL; [4 (7 AMINO[1,2,3]TRIAZOLO[4,5 D]PYRIMIDIN 3 YL)TETRAHYDROFURAN 2 YL]METHANOL; [4 (7 AMINOIMIDAZO[4,5 B]PYRIDIN 3 YL)TETRAHYDROFURAN 2 YL]METHANOL; ISODIDEOXYADENOSINE; UNCLASSIFIED DRUG;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANTIVIRAL ACTIVITY; ARTICLE; BINDING AFFINITY; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ADENOSINE TRIPHOSPHATE; ANTIVIRAL AGENTS; AZA COMPOUNDS; DIDEOXYADENOSINE; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; HIV-2; MOLECULAR STRUCTURE; PHOSPHATES; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE INHIBITORS; SUPPORT, NON-U.S. GOV'T;

EID: 0028149704     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00047a011     Document Type: Article

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