Programmed cell death (apoptosis) of mouse fibroblasts is induced by the topoisomerase II inhibitor etoposide

Molecular Pharmacology

Volumn 46, Issue 5, 1994, Pages 890-895

  Mizumoto, Kazuhiro ^a,b   Rothman, Ronald J ^a   Farber, John L ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AURINTRICARBOXYLIC ACID; CYCLOHEXIMIDE; ETOPOSIDE; GYRASE INHIBITOR; PROTEIN KINASE C INHIBITOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DIVISION; CELL PROTECTION; DNA CLEAVAGE; DNA SYNTHESIS INHIBITION; DRUG MECHANISM; ENZYME INHIBITION; FIBROBLAST; GROWTH INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS REGULATION;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ALKYLATING AGENTS; ANIMALS; APOPTOSIS; CELL DIVISION; CYCLOHEXIMIDE; DNA; DNA TOPOISOMERASES, TYPE II; ETOPOSIDE; ISOQUINOLINES; L CELLS (CELL LINE); METHYLNITROSOUREA; MICE; PIPERAZINES; PROTEIN BIOSYNTHESIS; PROTEIN KINASE C; PROTEIN SYNTHESIS INHIBITORS;

EID: 0028149572     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Liu, L. F., and J. C. Wang. Biochemistry of DNA topoisomerases and their poisons, in DNA Topoisomerases in Cancer (M. Potmesil and K. W. Kohn, eds.). Oxford University Press, New York, 13-22 (1991).
2. Drlica, K., and R. J. Franco. Inhibitors of DNA topoisomerases. Biochemistry 27:2253-2259 (1988).
3. Ross, W. E. DNA topoisomerases as targets for cancer therapy. Biochem. Pharmacol. 34:4191-4195 (1985).
4. Gewirtz, D. A. Does bulk damage to DNA explain the cytostatic and cytotoxic effects of topoisomerase II inhibitors? Biochem. Pharmacol. 42:2253-2258 (1991).
5. Wang, J. C. DNA topoisomerases. Annu. Rev. Biochem. 54:665-697 (1985).
6. D'Arpa, P., and L. F. Liu. Topoisomerase-targeting antitumor drugs. Biochim. Biophys. Acta 989:163-177 (1989).
7. Covey, J. M., K. W. Kohn, D. Kerrigan, E. J. Tilchen, and Y. Pommier. Topoisomerse II-mediated DNA damage produced by 4′-(9-acridinylamino)methanesulfon-m-anisidide and related acridines in L1210 cells and isolated nuclei: relation to cytotoxicity. Cancer Res. 48:860-865 (1988).
8. Arenas, M. J., R. G. Morris, and A. H. Wyllie. Apoptosis: the role of the endonuclease. Am. J. Pathol. 136:593-607 (1990).
9. Kerr, J. F. R., A. H. Wyllie, and A. R. Currie. Apoptosis: a basic biological phenomenon with wide ranging implications in tissue kinetics. Br. J. Cancer 26:239-257 (1972).
10. Sun, X.-M., R. T. Snowden, D. N. Skilleter, D. Dinsdale, M. G. Ormerod, and G. M. Cohen. A flow-cytometric method for the separation and quantitation of normal and apoptotic thymocytes. Anal. Biochem. 204:351-356 (1992).
11. Roy, C., D. L. Brown, J. E. Little, B. K. Valentine, P. R. Walker, M. Sikorska, J. Leblanc, and N. Chaly. The topoisomerase II inhibitor teniposide (VM-26) induces apoptosis in unstimulated mature murine lymphoctes. Exp. Cell Res. 200:416-424 (1992).
12. Lennon, S. V., S. J. Martin, and T. G. Cotter. Induction of apoptosis (programmed cell death) in tumour cell lines by widely diverging stimuli. Biochem. Soc. Trans. 18:343-345 (1990).
13. Kaufmann, S. H. Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note. Cancer Res. 49:5870-5878 (1989).
14. Chih, K.-H., C. K. King, and W. E. Ross. Abrogation of etoposide-mediated cytotoxicity by cycloheximide. Biochem. Pharmacol. 37:1117-1122 (1988).
15. Farber, J. L., and E. E. Young. Accelerated phospholipid degradation in anoxic rat hepatocytes. Arch. Biochem. Biophys. 211:312-320 (1981).
16. Burton, K. A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. Biochem. J. 62:315-323 (1956).
17. Sellins, K. S., and J. J. Cohen. Gene induction by γ-irradiation leads to DNA fragmentation in lymphoyctes. J. Immunol. 139:3199-3206 (1987).
18. Sambrook, J., E. F. Fritsch, and T. Maniatis. Molecular Cloning: A Laboratory Manual, Ed. 2, Vol. 1. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 6.34 (1989).
19. Saitoh, T., E. Masliah, L. W. Jin, G. M. Cole, T. Wieloch, and I. P. Shapiro. Biology of disease: protein kinases and phosphorylation in neurologic disorders and cell death. Lab. Invest. 64:596-616 (1991).
20. Hinchliffe, J. R. Cell death in embryogenesis, in Cell Death in Biology and Pathology (I. D. Bowen and R. A. Locksin, eds.). Chapman and Hall Press, New York, 35-78 (1981).
21. Searle, J., J. F. R. Kerr, and C. J. Bishop. Necrosis and apoptosis: distinct modes of cell death with fundamentally different significance. Pathol. Annu. 17:229-259 (1982).
22. Wyllie, A. H. Cell death. Int. Rev. Cytol. 17(suppl.):755-785 (1987).
23. Cohen, J. J., R. C. Duke, V. A. Fadok, and K. S. Sellins. Apoptosis and programmed cell death in immunity. Annu. Rev. Immunol. 10:267-293 (1992).
24. Wyllie, A. H. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature (Lond.) 284:555-556 (1980).
25. Tsukidate, K., K. Yamamoto, J. W. Snyder, and J. L. Farber. Microtubule antagonists activate programmed cell death (apoptosis) in cultured rat hepatocytes. Am. J. Pathol. 143:918-925 (1993).