Mitosis in transition

Cell

Volumn 79, Issue 4, 1994, Pages 563-571

  King, Randall W ^a   Jackson, Peter K ^a   Kirschner, Marc W ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; CYCLINE; PROTEIN KINASE;

CELL CYCLE PHASE; CELL GROWTH; ENZYME REGULATION; HUMAN; MITOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; REVIEW;

EID: 0028148715     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(94)90542-8     Document Type: Review

References (97)

1. CDC28 tyrosine phosphorylation is not required for entry into mitosis in S. cerevisaie
2. Closing the cell cycle circle in yeast G2 cyclin proteolysis initiated at mitosis persists until the activation of G1 cyclins in the next cycle
3. One of the protein phosphatase 1 isoenzymes in Drosophila is essential for mitosis
4. + in mitotic control of Schizosaccharomyces pombe: possible interaction of the gene product with microtubules
5. CDC28 in response to G1 and G2 cyclins
6. cdc2 restriction
7. Cyclin-like accumulation and loss of the putative kinetochore motor CENP-E results from coupling continuous synthesis with specific degradation at the end of mitosis
8. The ubiquitin-mediated proteolytic pathway mechanisms of recognition of the proteolytic substrate and involvement in the degradation of native cellular proteins
9. Negative regulation of the wee1 protein kinase by direct action of the nim1/cdr1 mitotic inducer
10. Monoclonal antibodies to mitotic cells
11. The bimG gene of Aspergillus nidulans required for completion of anaphase encodes a homolog of mammalian phosphoprotein phosphatase 1
12. Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate
13. Mitosis
14. Distinct molecular mechanisms regulate cell cycle timing at successive stages of Drosophila embryogenesis
15. wee1 mitotic inhibitor is a tyrosine/serine kinase
16. Genetic and molecular analysis of cdr1/nim1 in Schizosaccharomyces pombe
17. Triggering of cyclin degradation in interphase extracts of amphibian eggs by cdc2 kinase
18. Protein phosphatase type 1 in mammalian cell mitosis chromosomal localization and involvement in mitotic exit
19. cdc2 and a microtubule-associated protein kinase homolog in Xenopus oocytes and eggs
20. The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin-dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues
21. A novel cyclin associates with MO15/Cdk7 to form the CDK-activating kinase
22. Mutations in PRG1 a yeast proteasome-related gene cause defects in nuclear division and are suppressed by deletion of a mitotic cyclin gene
23. Cyclin B2 undergoes cell cycle-dependent nuclear translocation and when expressed as a non-destructible mutant causes mitotic arrest in HeLa cells
24. cdc2
25. A cyclin B homolog in S cerevisiae chronic activation of the Cdc28 protein kinase by cyclin prevents exit from mitosis
26. S cerevisiae 26S protease mutants arrest cell division in G2/metaphase
27. Cyclin is degraded by the ubiquitin pathway
28. Defective mitosis due to a mutation in the gene for a fission yeast 26S protease subunit
29. + protein kinase regulates entry into mitosis
30. Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit
31. + gene and a cytological study of its role in fission yeast mitosis
32. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
33. +: isolation of a sequence suc1 that suppresses cdc2 mutant function
34. A 40-kDa myelin basic protein kinase distinct from erk1 and erk2 is activated in mitotic HeLa cells
35. Methylated ubiquitin inhibits cyclin degradation in clam embryo extracts
36. Components of a system that ligates cyclin to ubiquitin and their regulation by the protein kinase cdc2
37. The Glc7 type 1 protein phosphatase of Saccharomyces cerevisiae is required for cell cycle progression in G2/M
38. Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor
39. The requirements for protein synthesis and degradation and the control of destruction of cyclins A and B in the meiotic and mitotic cell cycles of the clam embryo
40. Elimination of cdc2 phosphorylation sites in the cdc25 phosphatase blocks initiation of M-phase
41. Periodic changes in phosphorylation of the Xenopus cdc25 phosphatase regulate its activity
42. Phosphorylation changes associated with the early cell cycle in Xenopus eggs
43. Negative regulation of mitosis by the fission yeast protein phosphatase ppa2
44. Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation
45. cdc2 on threonine 14
46. cdc2 kinase activation in vertebrates
47. At least two kinase phosphorylate the MPM-2 epitope during Xenopus oocyte maturation
48. cdc25 is one of the MPM-2 antigens involved in the activation of maturation-promoting factor
49. The cdc25 protein controls tyrosine dephosphorylation of the cdc2 protein in a cell-free system
50. Regulation of the cdc25 protein during the cell cycle in Xenopus extracts
51. Bring on the phosphatases
52. Inhibition of cdc2 activation by INH/PP2A
53. An okadaic acid-sensitive phosphatase negatively controls the cyclin degradation pathway in amphibian eggs
54. Cyclin A-Cys41 does not undergo cell cycle-dependent degradation in Xenopus extracts
55. Cyclin A-cdc2 kinase does not trigger but delays cyclin degradation in interphase extracts of amphibian eggs
56. Essential roles for calcium and calmodulin in G2/M progression in Aspergillus nidulans
57. Control of programmed cyclin destruction in a cell-free system
58. Both cyclin AΔ60 and BΔ97 are stable and arrest cells in M-phase but only cyclin BΔ97 turns on cyclin destruction
59. mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2
60. A cyclin associated with the CDK-activating kinase MO15
61. Biochemistry of cell cycle checkpoints at the G2/M and metaphase/anaphase transitions
62. CDC28 protein kinase activity from Saccharomyces cerevisiae
63. The A- and B-type cyclin associated cdc2 kinases in Xenopus turn on and off at different times in the cell cycle
64. A MAP kinase-dependent spindle assembly checkpoint in Xenopus egg extracts
65. + gene
66. Cyclin synthesis drives the early embryonic cell cycle
67. The role of cyclin synthesis and degradation in the control of maturation promoting factor activity
68. cdc2 protein kinase in vertebrates
69. Ordering S phase and M phase in the cell cycle
70. + gene required for chromosome disjoining encodes one of two putative type 1 protein phosphatases
71. Differential occurrence of CSF-like activity and transforming activity of Mos during the cell cycle in fibroblasts
72. cdc2 cell cycle-regulated protein kinases is required to initiate mitosis in A. nidulans
73. Activation of the nimA protein kinase plays a unique role during mitosis that cannot be bypassed by absence of the bimE checkpoint
74. Spindle formation and chromatin condensation in cells blocked at interphase by mutation of a negative cell cycle control gene
75. Phosphorylation and inactivation of the mitotic inhibitor wee1 by the nim1/cdr1 kinase
76. Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport
77. cdc2
78. + functions as an inducer in the mitotic control of fission yeast
79. + functions in a regulatory network of protein kinase homologs controlling the initiation of mitosis
80. +, a gene encoding a protein kinase homolog
81. Conservation of mitotic controls in fission and budding yeasts
82. G1 phase progression cycling on cue
83. cdc2
84. cdc2 activation: identification of an activating kinase
85. MO15
86. cdc28
87. cdc2
88. Destruction of the CDC28/CLB mitotic kinase is not required for the metaphase to anaphase transition in budding yeast
89. Two distinct mechanisms for negative regulation of the Wee1 protein kinase
90. The Dbf2 and Dbf20 protein kinases of budding yeast are activated after the metaphase to anaphase cell cycle transition
91. cdc2
92. Anaphase onset and dephosphorylation of mitotic phosphoproteins occur concomitantly
93. Multiple roles for protein phosphatase 1 in regulating the Xenopus early embryonic cell cycle
94. The A- and B-type cyclins of Drosophila are accumulated and destroyed in temporally distinct events that define separable phases of the G2-M transition
95. Nim 1 kinase promotes mitosis by inactivating Wee1 tyrosine kinase
96. p21 is a universal inhibitor of cyclin kinases
97. CENP-E is a putative kinetochore motor that accumulates just before mitosis