Comparison of cefoperazone plus sulbactam with clindamycin plus gentamicin as treatment for intra-abdominal infections

Journal of Antimicrobial Chemotherapy

Volumn 34, Issue 3, 1994, Pages 391-401

  Greenberg, Richard N ^a   Cayavee, Paul ^a   Danko, Linda S ^a   Bowen, Karen ^a   Montazemi, Robert ^a   Kearney, Paul A ^a   Johnson, Steven B ^a   Strodel, William E ^a  

^a UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CLINDAMYCIN; GENTAMICIN; SULPERAZON;

ABDOMINAL INFECTION; ADULT; AGED; ANTIBIOTIC RESISTANCE; ARTICLE; BLOOD TOXICITY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG SAFETY; GASTROINTESTINAL HEMORRHAGE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY FAILURE; LIVER TOXICITY; MAJOR CLINICAL STUDY; PROTHROMBIN TIME; RANDOMIZED CONTROLLED TRIAL; RASH; RELAPSE; SUPERINFECTION; THROMBOCYTOSIS;

ABDOMEN; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BACTERIAL INFECTIONS; CEFOPERAZONE; CHI-SQUARE DISTRIBUTION; CLINDAMYCIN; DRUG THERAPY, COMBINATION; FEMALE; GENTAMICINS; HUMANS; MALE; MICROBIAL SENSITIVITY TESTS; MIDDLE AGED; PROSPECTIVE STUDIES; SULBACTAM; SUPERINFECTION; TREATMENT FAILURE;

EID: 0028148218     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/34.3.391     Document Type: Article

References (14)

1. Bawdon, R. E. & Madsen, P. O. (1986). High-pressure liquid chromatographic assay of sulbactam in plasma, urine, and tissue. Antimicrobial Agents and Chemotherapy 30, 231-3
2. Brismar, B., Malmborg A. S., Tunevall, G., Wretlind, B., Bergman, L., Mentzing, L. O. et al. (1992). Piperacillin-tazobactam versus imipenem-cilastatin for treatment of intra-abdominal infections. Antimicrobial Agents and Chemotherapy 36, 2766-73
3. Dallal, G. E. (1986). PC-Size Version 2.13: A program for sample size determination. American Statistician 40, 52
4. Fink, M. P., Helsmoortel, C. M., Arous, E. J., Doem, G. V., Moriarty, K. P., Fairchild, P. G. et al. (1989). Comparison of the safety and efficacy of parenteral ticarcillin/clavulanate and clindamycin/gentamicin in serious intra-abdominal infections. Journal of Antimicrobial Chemotherapy 24, Suppl. B, 147-56
5. Jauregui, L. E., Appelbaum, P. C., Fabian, T. C., Hageage, G., Strausbaugh, L. & Martin, L. F. (1990). A randomized clinical study of cefoperazone and sulbactam versus gentamicin and clindamycin in the treatment of intra-abdominal infections. Journal of Antimicrobial Chemotherapy 25, 423-33
6. Jones, R. N., Wilson, H. W., Thornsberry, C. & Barry, A. L. (1985). In vitro antimicrobial activity of cefoperazone-sulbactam combinations against 554 clinical isolates including a review and beta-lactamase studies. Diagnostic Mircobiology and Infectious Diseases 3, 489-99
7. National Committee for Clinical Laboratory Standards. (1990a). Performance Standards for Antimicrobial Disk Susceptibility Tests Fourth Edition: Approved Standard M2-A4. NCCLS, Villanova, PA
8. National Committee for Clinical Laboratory Standards. (1996). Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically 2nd edn Approved Standard M7-A2. NCCLS, Villanova, PA
9. National Committee for Clinical Laboratory Standards. (1990c). Methods for Antimicrobial Susceptibility Testing of Anaerobic Bacteria 2nd edn Approved Standard MII-A2. NCCLS, Villanova, PA
10. Reitberg, D. P., Marble, D. A., Schultz, R. W., Whall, T. J. & Schentag, J. J. (1988a). Pharmacokinetics of cefoperazone (2-0 g) and sulbactam (10g) coadministrated to subject with normal renal function, patients with decreased renal function, and patients with end-stage renal disease on hemodialysis. Antimicrobial Agents and Chemotherapy 32, 503-9
11. Reitberg, D. P., Whall, T. J., Chung, M., Blickens, D., Swarz, H. & Arnold, J. (1986). Multiple-dose pharmacokinetics and toleration of intravenously administered cefoperazone and sulbactam when given as single agents or in combination. Antimicrobial Agents and Chemotherapy 32, 42-6
12. Sanders, C. C. (1992). 1-Lactamases of Gram-negative bacteria: new challenges for new drugs. Clinical Infectious Diseases 14, 1089-99
13. Study Group of Intraabdominal Infections. (1986). A randomized controlled trial of ampicillin plus sulbactam vs. gentamicin plus clindamycin in the treatment of intraabdominal infections: a preliminary report. Reviews of Infectious Diseases 8, Suppl. 5, S583-8
14. Walker, A. P., Nichols, R. L., Wilson, R. F., Bivens, B. A., Trunkey, D. D., Edmiston, C. E. et al. (1993). Efficacy of a beta-lactamase inhibitor combination for serious intraabdominal infections. Annals of Surgery 217, 115-21