Design and Synthesis of Potent and Highly Selective Thrombin Inhibitors

Journal of Medicinal Chemistry

Volumn 37, Issue 23, 1994, Pages 3889-3901

  Hilpert, Kurt ^a   Ackermann, Jean ^a   Banner, David W ^a   Gast, Alain ^a   Gubernator, Klaus ^a   Hadváry, Paul ^a   Labler, Ludvik ^a   Müller, Klaus ^a   Schmid, Gérard ^a   Tschopp, Thomas B ^a   Van de Waterbeemd, Han ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHROMBOCYTIC AGENT; ARGATROBAN; BENZAMIDINE; N (2 NAPHTHYLSULFONYL)GLYCYL 4 AMIDINOPHENYLALANINE PIPERIDIDE; NAPSAGATRAN; THROMBIN; TOSYLARGININE METHYL ESTER; TRYPSIN;

ANIMAL CELL; ANTICOAGULATION; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; INHIBITION KINETICS; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; PROTEINASE INHIBITION; STRUCTURE ACTIVITY RELATION; THROMBOGENESIS;

AMINO ACIDS; ANIMAL; ANTITHROMBINS; ASPARTIC ACID; DRUG DESIGN; HALF-LIFE; HUMAN; PIPERIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPSIN INHIBITORS;

EID: 0028143534     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00049a008     Document Type: Article

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