p130/pRb2 Has Growth Suppressive Properties Similar to yet Distinctive from Those of Retinoblastoma Family Members pRb and P107

Cancer Research

Volumn 54, Issue 21, 1994, Pages 5556-5560

  Sun, Yi ^c   Colburn, Nancy ^c   Baldi, Alfonso ^a   De Luca, Antonio ^a   Fu, Yan ^a   Giordano, Antonio ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b THOMAS JEFFERSON UNIVERSITY HOSPITAL   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; PROTEIN P107; RETINOBLASTOMA PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CANCER INHIBITION; CELL PROLIFERATION; GENE REARRANGEMENT; GROWTH INHIBITION; HUMAN; HUMAN CELL; MOLECULAR CLONING; PRIORITY JOURNAL; PROTEIN ANALYSIS; RETINOBLASTOMA; TUMOR SUPPRESSOR GENE;

CELL DIVISION; HUMAN; NASOPHARYNGEAL NEOPLASMS; PROTEINS; RETINOBLASTOMA PROTEIN; RNA, MESSENGER; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR CELLS, CULTURED; TUMOR STEM CELL ASSAY;

EID: 0028143074     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Knudson, A.G. Jr. Mutation and cancer: statistical study of retinoblastoma. Proc. Natl. Acad. Sci. USA, 68: 820-823, 1971.
2. Lasko, D. Cavenee, W. and Nordenskjold, M. Loss of constitutional heterozygosity in human cancer. Annu. Rev. Genet. 25: 281-314, 1991.
3. Goodrich, D.W. Wang, N.P. Qian, Y.W. Lee, E.Y.H. and Lee, W.H. The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle. Cell, 67: 297-302, 1991.
4. Hinds, P.W. Mittnacht, S. Dulic, V. Arnold, A. Reed, S.I. and Weinberg, R.A. Regulation of retinoblastoma protein function by ectopic expression of human cyc-lins. Cell, 70: 993-1006, 1992.
5. Zhu, L. Van Den Heuvel, S. Helin, K. Fattaey, A. Ewen, M. Livingston, D. Dyson, N. and Harlow, E. Inhibition of cell proliferation by 107, a relative of the retinoblastoma protein. Genes & Dev. 7: 1111-1125, 1993.
6. Chellappan, S. Hiebert, S. Mudryj, M. Horowitz, J. and Nevins, J. The E2F transcription factor is a cellular target for the RB protein. Cell, 65: 10531061, 1991.
7. Hiebert, S.W. Chellappan, S.P. Horowitz, J.M. and Nevins, J.R. The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F. Genes & Dev. 6: 177-185, 1992.
8. Qian, Y. Luckey, C. Horton, L. Esser, M. and Templeton, D.J. Biological function of the retinoblastoma protein requires distinct domains for hyperphosphorylation and transcription factor binding. Mol. Cell. Biol. 12: 5363-5372, 1992.
9. Qin, X.Q. Chittenden, T. Livingston, D.M. and Kaelin, W.G. Identification of a growth suppression domain within the retinoblastoma gene product. Genes & Dev. 6: 953-964, 1992.
10. Ewen, M. Xing, Y. Lawrence, J.B. and Livingston, D.M. Molecular cloning, chromosomal mapping, and expression of the cDNA for p. 07, a retinoblastoma gene product-related protein. Cell, 66: 1155-1164, 1991.
11. Mayol, X. Graña, X. Baldi, A. Sang, N. Hu, Q. and Giordano, A. Cloning of a new member of the retinoblastoma gene family (pRb2), which bind to the E1A transforming domain. Oncogene, 8: 2561-2566, 1993.
12. Li, Y. Graham, C. Lacy, S.M.V. Duncan, A. and Whyte, P. The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E. Genes & Dev. 7: 2366-2377, 1993.
13. Hannon, G.J. Demetrick, D. and Beach, D. Isolation of the Rb-related p. 30 through its interaction with CDK2 and cyclins. Genes & Dev. 7: 2378-2391, 1993.
14. Hinds, P.W. Mittnacht, S. Dulic, V. Arnold, A. Reed, S.I. and Weinberg, R.A. Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell, 70: 993-1006, 1992.
15. Quin, X.Q. Chitteden, T. Livingston, D. and Kaelin, W.G. Identification of a growth suppression domain within the retinoblatoma gene product. Gen. & Dev. 6: 953-964, 1992.
16. Cao, L. Faha, B. Dembski, M. Tsai, L.H. Harlow, E. and Dyson, N. Independent binding of the retinoblastoma protein and p. 07 to the transcription factor E2F. Nature (Lond.), 355: 176-179, 1992.
17. Chittenden, T. Livingston, D.M. and De Caprio, J. Cell-cycle analysis of the E2F in primary human T cells reveals novel E2F complexes and biochemically distinct forms of free E2F. Mol. Cell. Biol. 13: 3975-3983, 1993.
18. Shirodkar, S. Ewen, M. De Caprio, J.A. Morgan, J. Livingston, D.M. and Chittenden, T. The transcription factor E2F interacts with the retinoblastoma product and a p. 07 cyclin A complex in a cell-cycle regulated manner. Cell, 68: 157-166, 1992.
19. Cobrinik, D. Whyte, P. Peeper, D. S. Jacks, T. and Weinberg, A. Cell cycle-specific association of the E2F with the p. 30 E1A-binding protein. Genes & Dev. 7: 2392-2404, 1993.
20. Ewen, M.E. Ludlow, J.W. Marsilio, E. De Caprio, J.A. Millikan, R.C. Cheng, S.H. Paucha, E. and Livingston, D.M. An N-terminal transformation-governing sequence of SV40 large T antigen contributes to the binding of both p. 10 Rb and a second cellular protein, p. 20. Cell, 58: 257-267, 1989.
21. Yeung, R.S. Bell, D.W. Testa, J.R. Mayol, X. Baldi, A. Graña, X. Klinga-Levan, K. Knudson, A.G. and Giordano, A. The retinoblastoma-related gene, Rb2 maps to human chromosome 16q12 and rat chromosome 19. Oncogene, 8: 3465-3468, 1993.
22. Yan, L. Xi, Z. Drettener, B. Epidemiological studies of nasopharyngeal cancer in the Guangzhou area, China. Preliminary report. Acta Otolaryngol. 107: 424-427, 1988.
23. Mascolo, A. Levin, S. and Giordano, A. A molecular biological approach to the study of nasopharyngeal cancer in Chinese Garment workers. Ramazzini Newslett. 2: 54-58, 1992.
24. Helin, K. Less, J.A. Vidal, M. Dyson, N. Harlow, E. and Fattaey, A. A cDNA encoding a pRb-binding protein with properties of the transcription factor E2F. Cell, 70: 337-350, 1992.
25. Sun, Y. Hegamyer, G. Cheng, Y.J. Hildesheim, A. Chen, J.Y. Chen, I.H. Cao, Y. Yao, K.T. and Colburn, N.H. An infrequent point mutation of the p. 3 gene in human nasopharyngeal carcinoma. Proc. Natl. Acad. Sci. USA, 89: 6516-6520, 1992.
26. Huttner, K.M. Barbosa, J.A. Scangos, G.A. Pratcheva, D.D. and Ruddle, F.H. DNA mediated gene transfer without carrier DNA.J. Cell Biol. 91: 153-156, 1981.
27. Sun, Y. Nakamura, K. Hegamyer, G. Dong, Z. and Colburn, N.H. No point mutation of Ha-ras or p. 3 genes expressed in preneoplastic- to-neoplastic progression as modeled in mouse JB6 cell variants. Mol. Carcinog. 8: 49-57, 1993.
28. Ausubel, F.M. Brent, R. Kingston, R.E. Moore, D.D. Seidman, J.G. Smith, J.A. and Struhl, K. Preparation and analysis of DNA. In: Current Protocol in Molecular Biology. Vol. 1, pp. 2.1.1-2.1.2. New York: John Wiley & Sons, Inc. 1987.
29. Mattox, W. Ryner, L. and Baker, B. Autoregulation and multifunctionality among trans-activating factors that regulate alternative pre-mRNA processing. J. Biol. Chem. 267: 19023-19026, 1992.
30. Breitbart, R.E. Andreadis, A. and Nadal-Ginard, B. Annu. Rev. Biochem. 56: 467-495, 1987.
31. McKeown, M. Alternative mRNA splicing. Annu. Rev. Biochem. 8: 133-155, 1992.
32. Baker, S.J. Markowitz, S. Fearon, E.R. Wilson, J.K.V. and Vogelstein, B. Suppression of the human colorectal carcinoma cell growth by wild type p. 3. Science (Washington DC), 249: 912-915, 1990.
33. Diller, L. Kassel, J. Camille, E.N. Gryka, M.A. Litwak, G. Gebhardt, M. Bressac, B. Ozturk, M. Baker, S.J. Vogelstein, B. and Friend, S.H. p. 3 functions as a cell-cycle control protein in osteosarcomas. Mol. Cell. Biol. 10: 5772-5781, 1990.
34. Templeton, D.J. Park, S.H. Lanier, L. and Weinberg, R.A. Nonfunctional mutants of the retinoblastoma protein are characterized by defects in phosphorylation, viral oncoprotein association, and nuclear tethering. Proc. Natl. Acad. Sci. USA, 88: 3033-3037, 1991.
35. Huang, H.J.S. Yee, J.K. Shew, J.Y. Chen, P.L. Bookstein, R. Friedmann, T. Lee, E.Y.H.P. and Lee, W.H. Suppression of the neoplastic phenotype by replacement of the Rb gene in human cancer cells. Science (Washington DC), 242: 1563-1566, 1988.
36. Bookstein, R. Shew, J.Y. Chen, P.L. Scully, P. and Lee, W.H. Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated Rb gene. Science (Washington DC), 247: 712-715, 1990.
37. Giordano, A. McCall, C. Whyte, P. and Franza, B.R. Human cyclin A and the retinoblastoma protein interact with similar but distinguishable sequences in the adenovirus E1A gene product. Oncogene, 6: 481-485, 1991.
38. Giordano, A. Lee, J. Scheppler, J.A. Herrmann, C. Harlow, E. Deuschle, U. Beach, D. and Franza, B.R. Cell-cycle regulation of histone HI kinase activity associated with the adenoviral protein E1A. Science (Washington DC), 253: 1271-1275, 1991.
39. Moran, E. DNA tumor virus transforming proteins and the cell cycle. Curr. Opin. Genet. Dev. 3: 63-70, 1993.
40. Sun, Y. Hegamyyer, and Colburn, N. Nasopharyngeal carcinoma shows no detectable retinoblastoma susceptibility gene alterations. Oncogene, 8: 791-795, 1993.