5-[(3-Nitropyrid-2-yl)amino]indoles: Novel Serotonin Agonists with Selectivity for the 5-HT1D Receptor. Variation of the C3 Substituent on the Indole Template Leads to Increased 5-HT1D Receptor Selectivity

Journal of Medicinal Chemistry

Volumn 37, Issue 16, 1994, Pages 2509-2512

  Macor, John E ^a   Blank, David H ^a   Fox, Carol B ^a   Lebel, Lorraine A ^a   Newman, Michael E ^a   Post, Ronald J ^a   Ryan, Kevin ^a   Schmidt, Anne W ^a   Schulz, David W ^a   Koe, B Kenneth ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (1 METHYL 2 PYRROLIDINYLMETHYL) 5 (3 NITRO 2 PYRIDYLAMINO)INDOLE; 3 (1 METHYL 3 PYRROLIDINYL) 5 (3 NITRO 2 PYRIDYLAMINO)INDOLE; 3 (2 DIMETHYLAMINOETHYL) 5 (3 NITRO 2 PYRIDYLAMINO)INDOLE; 5 (3 NITRO 2 PYRIDYLAMINO) 3 (2 PYRROLIDINYLMETHYL)INDOLE; 5 [(3 NITRO 2 PYRIDYL)AMINO]INDOLE; CP 113113; CP 123803; CP 135807; SEROTONIN; SEROTONIN AGONIST; SEROTONIN RECEPTOR; SUMATRIPTAN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG BINDING SITE; DRUG CONFORMATION; DRUG RECEPTOR BINDING; HYDROGEN BOND; RECEPTOR AFFINITY;

COMPARATIVE STUDY; INDOLES; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; RECEPTORS, SEROTONIN; SEROTONIN AGONISTS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SUMATRIPTAN;

EID: 0028136260     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00042a003     Document Type: Article

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