Strong inhibition of mammalian lipoxygenases by the antiinflammatory seleno-organic compound ebselen in the absence of glutathione

Biochemical Pharmacology

Volumn 48, Issue 1, 1994, Pages 65-74

  Schewe, Christiane ^a   Schewe, Tankred ^a   Wendel, Albrecht ^b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF KONSTANZ   (Germany)

Author keywords

cyclooxygenase; ebselen; glutathione; hydroperoxy fatty acids; lipoxygenase; selenium

Indexed keywords

ARACHIDONATE 15 LIPOXYGENASE; ARACHIDONATE 5 LIPOXYGENASE; EBSELEN; GLUTATHIONE; GLUTATHIONE PEROXIDASE; LINOLENIC ACID; PROSTAGLANDIN SYNTHASE; STEARIC ACID;

ANTIOXIDANT ACTIVITY; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; ENZYME INHIBITION; ENZYME LOCALIZATION; ENZYME PURIFICATION; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; RABBIT;

ANIMAL; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARACHIDONATE 15-LIPOXYGENASE; ARACHIDONATE 5-LIPOXYGENASE; AZOLES; CYCLOOXYGENASE INHIBITORS; GLUTATHIONE; HUMAN; LINOLEIC ACIDS; LIPOXYGENASE INHIBITORS; ORGANOSELENIUM COMPOUNDS; RABBITS;

EID: 0028136243     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(94)90224-0     Document Type: Article

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