Ectopic Hoxa-1 induces rhombomere transformation in mouse hindbrain

Development

Volumn 120, Issue 9, 1994, Pages 2431-2442

  Zhang, Maobin ^a   Kim, Hee Joong ^a   Marshall, Heather ^b   Gendron Maguire, Maureen ^c   Lucas, Debra A ^a   Baron, Agnès ^d   Gudas, Lorraine J ^e   Gridley, Thomas ^c   Krumlauf, Robb ^b   Grippo, Joseph F ^a  

^a Hoffmann La Roche Department of Toxicology and Pathology   (United States)

^b NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^c HOFFMANN LA ROCHE INC   (United States)

^d BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

^e WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Hindbrain development; Hox genes; RA; Rhombomere

Indexed keywords

BETA ACTIN; BETA GALACTOSIDASE;

ANIMAL EXPERIMENT; ARTICLE; CELL MIGRATION; CELL TRANSFORMATION; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; EMBRYO; ENZYME ACTIVITY; GENE ACTIVITY; GENE EXPRESSION; HOMEOBOX; MOUSE; NEURAL CREST CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; RHOMBENCEPHALON; TRANSGENE; TRANSGENIC MOUSE;

ACTINS; ANIMALS; BASE SEQUENCE; GENE EXPRESSION REGULATION; GENES, HOMEOBOX; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; MORPHOGENESIS; NERVOUS SYSTEM; NEURAL CREST; PROMOTER REGIONS (GENETICS); RHOMBENCEPHALON; TRANSFORMATION, GENETIC;

ANIMALIA; INVERTEBRATA; MUS MUSCULUS; VERTEBRATA;

EID: 0028131168     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. Akam, M. (1989). Hox and HOM: homologous gene clusters in insects and vertebrates. Cell 57, 347-349.
2. Andrew, D. J. and Scott, M. P. (1992). Downstream of the homeotic genes. New Biologist 4, 5-15.
3. Armstrong, R. B., Kim, H.-J., Grippo, J. and Levin, A. (1992). Retinoids for the future: Investigational approaches for the identification of new compounds. J. Am. Acad. Dermatol. 27, S38-S42.
4. Baron, A., Feaherstone, M. S., Hill, R. E., Hall, A., Galliot, B., Duboule, D. (1987). Hox-1.6: a mouse homeobox-containing gene member of the Hox-1 complex. EMBO J. 6, 2977-2986.
5. Carpenter, E. M., Goddard, J. M., Chisaka, O., Manley, N. R. and Capecchi, M. R. (1993). Loss of Hoxa-1 (Hox-1.6) function results in the reorganization of the murine hindbrain. Development 118, 1063-1075.
6. Catron, K. M., Iler, N. and Abate, C. (1993). Nucleotides flanking a conserved TAAT core dictate the DNA binding specificity of three murine homeodomain protein. Molec. Cell. Biol. 13, 2354-2365.
7. Chavrier, P., Zerial, M., Lemaire, P., Almendral, J., Bravo, R. and Charnay, P. (1988). A gene encoding a protein with zinc fingers is activated during G0/G1 transition in cultured cells. EMBO J. 7, 29-35.
8. Chisaka, O. and Capecchi, M. R. (1991). Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1. 5. Nature 350, 473-479.
9. Chisaka, O., Musci, T. S. and Capecchi, M. R. (1992). Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox gene Hox-1. 6. Nature 355, 516-520.
10. Chouinard, S. and Kaufman, T. C. (1991). Control of expression of the homeotic labial (lab) locus of Drosophila melanogaster: evidence for both positive and negative autogenous regulation. Development 113, 1267-1280.
11. Conlon, R. A. and Rossant, J. (1992). Exogenous retinoic acid rapidly induces anterior expression of murine Hox-2 genes in vivo. Development 116, 357-368.
12. Dodd, J., Morton, S. B., Karagogeos, D., Yamamoto, M. and Jessell, T. (1988). Spatial regulation of axonal glycoprotein expression on subsets of embryonic spinal neurons. Neuron 1, 105-116.
13. Fraser, S. E., Keynes, R. J. and Lumsden, A. (1990). Segmentation in the chick embryo hindbrain is defined by cell lineage restriction. Nature 344, 431-435.
14. Frohman, M. A., Boyle, M. and Martin, G. R. (1990). Isolation of the mouse Hox-2.9 gene: analysis of embryonic expression suggests that positional information along the anterior-posterior axis is specified by mesoderm. Development 110, 589-607.
15. Frohman, M. A. and Martin, G. R. (1992). Isolation and analysis of embryonic expression of Hox-4.9, a member of the murine labial-like gene family. Mech. Dev. 38, 55-67.
16. Gendron-Maguire, M., Mallo, M., Zhang, M. and Gridley, T. (1993). Hoxa-2 mutant mice exhibit homeotic transformation of skeletal elements derived from cranial neural crest. Cell 75, 1317-1331.
17. Gunning, P., Leavitt, J., Muscat, G., Ng, S.-Y. and Kedes, L. (1987). A human β-actin expression vector system directs high-level accumulation of antisense transcripts. Proc. Natl. Acad. Sci. USA 84, 4831-4835.
18. Guthrie, S., Muehamore, I., Kuroiwa, A., Marshall, H., Krumlauf, R. and Lumsden, A. (1992). Neuroectodermal autonomy of Hox-2. 9 expression revealed by rhombomere transpositions. Nature 356, 157-159.
19. Hofmann, C. and Eichele, G. (1994). Retinoids in development. In The Retinoids: Biology, Chemistry, and Medicine, 2nd edition (ed. M. B. Sporn, A. B. Roberts and D. S. Goodman), pp. 545-572. New York: Raven Press.
20. Hogan, B., Constantini, F. and Lacy, E. (1986). Manipulating the Mouse Embryo: A Laboratory Manual. New York: Cold Spring Harbor Laboratory Press.
21. Hunt, P., Gulisano, M., Cook, M., Sham, M.-H., Faiella, A., Wilkinson, D., Boncinelli, E. and Krumlauf, R. (1991). A distinct Hox code for the brachial region of the head. Nature 353, 861-864.
22. Jegalian, B. G. and De Robertis, R. M. (1992). Homeotic transformations in the mouse induced by overexpression of a human Hox-3.3 transgene. Cell 71, 901-910.
23. Kessel, M. (1993). Reversal of axonal pathways from rhombomere 3 correlates with extra Hox expression domains. Neuron 10, 379-393.
24. Kessel, M., Balling, R. and Gruss, P. (1990). Variations of cervical vertebrae after expression of a Hox-1.1 transgene in mice. Cell 61, 301-308.
25. Kessel, M. and Gruss, P. (1991). Homeotic transformations of murine vertebrae and concomitant alteration of Hox codes induced by retinoic acid. Cell 67, 89-104.
26. Kothary, R., Clapoff, S., Darling, S., Perry, M. D., Moran, L. A. and Rossant, J. (1989). Inducible expression of a hsp68-lacZ hybrid gene in transgenic mice. Development 105, 707-714.
27. Krumlauf, R. (1992). Evolution of the vertebrate Hox homeobox genes. BioEssays 14, 245-252.
28. Krumlauf, R. (1993). Hox genes and pattern formation in the branchial region of the vertebrate head. Trends in Genetics 9, 106-112.
29. Langston, A. W. and Gudas, L. J. (1992). Identification of a retinoic acid responsive enhancer 3′ of the murine homeobox gene Hox-1.6. Mech. Dev. 38, 217-228.
30. LaRosa, G. J. and Gudas, L. J. (1988). Early retinoic acid-induced F9 teratocarcinoma stem cell gene ERA-1: alternate splicing creates transcripts for a homeobox-containing protein and one lacking the homeobox. Molec. Cell. Biol. 8, 3906-3917.
31. Le Mouellic, H., Lallemand, Y. and Brulet, P. (1992). Homeosis in the mouse induced by a null mutation in the Hox-3.1 gene. Cell 69, 251-264.
32. Lufkin, T., Dierich, A., LeMeur, M., Mark, M. and Chambon, P. (1991). Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expression. Cell 66, 1105-1119.
33. Lufkin, T., Mark, M., Hart, C. P., Dolle, P., LeMeur, M. and Chambon, P. (1992). Homeotic transformation of the occipital bones of the skull by ectopic expression of a homeobox gene. Nature 359, 835-841.
34. Lumsden, A. (1990). The cellular basis of segmentation in the developing hindbrain. Trends in Neurosci. 13, 329-335.
35. Lumsden, A. and Keynes, R. (1989). Segmental patterns of neuronal development in the chick hindbrain. Nature 337, 424-428.
36. Lumsden, A., Sprawson, N. and Graham, A. (1991). Segmental origin and migration of neural crest cells in the hindbrain region of the chick embryo. Development 113, 1281-1291.
37. Mark, M., Lufkin, T., Vonesch, J.-L., Ruberte, E., Oliver, J.-C., Dolle, P., Gorry, P., Lumsden, A. and Chambon, P. (1993). Two rhombomeres are altered in Hoxa-1 mutant mice. Development 119, 319-338.
38. Marshall, H., Nonchev, S., Sham, M. H., Muchamore, I., Lumsden, A. and Krumlauf, R. (1992). Retinoic acid alters hindbrain Hox code and induces transformation of rhombomeres 2/3 into a 4/5 identity. Nature 360, 737-741.
39. McGinnis, W., Hart, C. P., Gehring, W. J. and Ruddle, F. H. (1984). Molecular cloning and chromosome mapping of a mouse DNA sequence homologous to homeotic genes of Drosophila. Cell 38, 675-680.
40. McGinnis, W. and Krumlauf, R. (1992). Homeobox genes and axial patterning. Cell 68, 283-302.
41. Morgan, B. A., Izpisua-Belmonte, J.-C., Duboule, D. and Tabin, C. J. (1992). Targeted misexpression of Hox-4.6 in the avian limb bud causes apparent homeotic transformation. Nature 358, 236-239.
42. Morriss-Kay, G. M., Murphy, P., Hill, R. E. and Davidson, D. R. (1991). Effects of retinoic acid excess on expression of Hox 2.9 and Krox-20 and on morphological segmentation in the hindbrain of mouse embryos. EMBO J. 19, 2985-2995.
43. Murphy, P. and Hill, R. E. (1991). Expression of the mouse labial-like homeobox-containing genes. Hox 2.9 and Hox 1.6, during segmentation of the hindbrain. Development 111, 61-74.
44. Pollock, R. A., Jay, G. and Bieberich, C. J. (1992). Altering the boundaries of Hox 3.1 expression: evidence for antipodal gene regulation. Cell 71, 911-923.
45. Ramirez-Solis, R., Zheng, H., Whiting, J., Krumlauf, R. and Bradley, A. (1993). Hoxb-4 (Hox-2.6) mutant mice show homeotic transformation of a cervical vertebra and defects in the closure of the sternal rudiments. Cell 73, 279-294.
46. Schneider-Maunoury, S., Topilko, P., Seitandou, T., Levi, G., Cohen-Tannoudji, M., Pournin, S., Babinet C., Charnay P. (1993). Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain. Cell 75, 1199-214.
47. Scott, M. P. (1992). Vertebrate homeobox gene nomenclature. Cell 71, 551-553.
48. Sham, M. H., Vesque, C., Nonchev, S., Marshall, H., Frain, M., Das Gupta, R. D., Whiting, J., Wilkinson, D., Charnay, P. and Krumlauf, R. (1993). The zinc finger gene Krox-20 regulates HoxB2 (Hox2.8) during Hindbrain segmentation. Cell 72, 183-196.
49. Simeone, A., Acampora, D., Arcioni, L., Andrews, P. W., Boncinelli, E. and Mavilio, F. (1990). Sequential activation of Hox2 homeobox genes by retinoic acid in human embryonal carcinoma cells. Nature 346, 763-766.
50. Simeone, A., Acampora, D., Nigro, V., Faiella, A., D'Esposito, M., Stornaiurolo, A., Mavilio, F. and Boncinelli, E. (1991). Differential regulation by retinoic acid of the homeobox genes for the four HOX loci in human embryonal carcinoma cells. Mech. Dev. 33, 215-228.
51. Simon, H. and Lumsden, A. (1993). Rhombomere-specific origin of the contralateral vestibulo-acoustic efferent neurons and their migration across the embryonic midline. Neuron 11, 209-220.
52. Swiatek, P. and Gridley, T. (1993). Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20. Genes Dev. 7, 2071-2084.
53. Tan, D.-P., Ferrante, J., Nazarali, A., Shao, X., Kozak, C. A., Guo, V. and Nirenberg, M. (1992). Murine Hox-1.11 homeobox gene structure and expression. Proc. Natl. Acad. Sci. USA 89, 6280-6284.
54. Vaage, S. (1969). The segmentation of the primitive neural tube in chick embryos. Adv. Anat. Embryol. Cell Biol. 41, 1-88.
55. Walter, C. A., Nasr-Schirf, D. and Luna, V. J. (1989). Identification of transgenic mice carrying the CAT gene with PCR amplification. BioTechnichiques 7, 1065-1070.
56. Wilkinson, D. G., Bhatt, S., Chavrier, P., Bravo, R. and Charnay, P. (1989). Segment-specific expression of a zinc finger gene in the developing nervous system of the mouse. Nature 337, 461-464.
57. Wilkinson, D. G. and Green, J. (1990). In situ hybridization and three-dimensional reconstruction of serial sections. In Postimplantation Mouse Embryos: A Practical Approach (eds. D. Rickwood and D. L. Cockcroft), pp. 155-171. New York: Oxford-IRL Press.