Stability of peptide nucleic acids in human serum and cellular extracts

Biochemical Pharmacology

Volumn 48, Issue 6, 1994, Pages 1310-1313

  Demidov, Vadim V ^a,b   Potaman, Vladimir N ^b   Frank Kamenetskil, M D ^d   Egholm, Michael ^c   Buchard, Ole ^c   Sönnichsen, Søren H ^a   Nlelsen, Peter E ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b INSTITUTE OF MOLECULAR GENETICS   (Russian Federation)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d BOSTON UNIVERSITY   (United States)

Author keywords

anti sense gene drugs; biostability; cellular extracts; human serum; peptide nucleic acid (PNA); proteases

Indexed keywords

CELL EXTRACT; CORTICOTROPIN[4-10]; OLIGONUCLEOTIDE; PEPTIDASE; PEPTIDE NUCLEIC ACID; PROTEINASE;

ANIMAL TISSUE; ARTICLE; BODY FLUID; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; DRUG DEGRADATION; DRUG STABILITY; EHRLICH ASCITES TUMOR CELL; ESCHERICHIA COLI; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MICROCOCCUS LUTEUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SERUM;

AMINO ACID SEQUENCE; BASE SEQUENCE; BLOOD; DRUG DESIGN; DRUG STABILITY; ENDOPEPTIDASE K; MOLECULAR SEQUENCE DATA; OLIGODEOXYRIBONUCLEOTIDES; OLIGOPEPTIDES; PEPTIDE HYDROLASES; SERINE ENDOPEPTIDASES; SOLUBILITY; SUPPORT, NON-U.S. GOV'T; TISSUE EXTRACTS;

EID: 0028129843     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(94)90171-6     Document Type: Article

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