Gene Therapy for the Treatment of Recurrent Pediatric Malignant Astrocytomas with In Vivo Tumor Transduction with the Herpes Simplex Thymidine Kinase Gene/Ganciclovir System

Human Gene Therapy

Volumn 5, Issue 7, 1994, Pages 863-890

  Raffel, Corey ^a   Culver, Kenneth ^b   Kohn, Donald ^a   Nelson, Marvin ^a   Siegel, Stuart ^a   Gillis, Floyd ^a   Link, Charles J ^b   Villablanca, Judith G ^a   Anderson, W French ^c  

^a CHILDREN S HOSPITAL LOS ANGELES   (United States)

^b Iowa Cancer Research Foundation   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

gene transfer; malignant astrocytoma; pediatric brain tumor; retrovirus

Indexed keywords

BETA GALACTOSIDASE; DEXAMETHASONE; GANCICLOVIR; THYMIDINE KINASE;

ANEMIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTOMA; BRAIN TUMOR; CANCER GROWTH; CEREBROSPINAL FLUID; CHEMOSENSITIVITY; CHILDHOOD CANCER; CLINICAL TRIAL; CLONING VECTOR; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DEVELOPMENT; DRUG TOXICITY; FEVER; GENE THERAPY; GENE TRANSFER; GENETIC TRANSDUCTION; GRANULOCYTOPENIA; HERPES SIMPLEX VIRUS; HUMAN; IMMUNE DEFICIENCY; INTRATUMORAL DRUG ADMINISTRATION; LIVER TOXICITY; MOUSE; NONHUMAN; PATIENT SELECTION; RASH; RAT; RETROVIRUS; RHESUS MONKEY; THROMBOCYTOPENIA; VIRUS GENE;

ADOLESCENT; ANIMALS; ASTROCYTOMA; CELL LINE; CHILD; CHILD, PRESCHOOL; CLINICAL PROTOCOLS; DRUG RESISTANCE; FEASIBILITY STUDIES; FEMALE; GANCICLOVIR; GENE THERAPY; GENETIC VECTORS; HUMANS; INFORMED CONSENT; INJECTIONS, SPINAL; MACACA MULATTA; MALE; MICE; NEOPLASM RECURRENCE, LOCAL; RETROVIRIDAE; RISK; SIMPLEXVIRUS; SUPRATENTORIAL NEOPLASMS; THYMIDINE KINASE; TRANSDUCTION, GENETIC; TUMOR STEM CELLS;

ANIMALIA; HERPES; MACACA MULATTA; MAMMALIA; MURINAE; PRIMATES; SIMPLEXVIRUS; UNIDENTIFIED RETROVIRUS;

EID: 0028124751     PISSN: 10430342     EISSN: 15577422     Source Type: Journal    
DOI: 10.1089/hum.1994.5.7-863     Document Type: Article

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