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Volumn 47, Issue 2, 1994, Pages 155-169

HIV resistance to reverse transcriptase inhibitors

Author keywords

combination chemotherapy; dideoxynucleosides; human immunodeficiency virus; non nucleoside reverse transcriptase inhibitors; reverse transcriptase inhibitors; virus drug resistance

Indexed keywords

1 [(2 HYDROXYETHOXY)METHYL] 6 (PHENYLTHIO)THYMINE; 2 NITROPHENYL PHENYL SULFONE; 2 PYRIDONE DERIVATIVE; 2,3 DIHYDRO 9B PHENYLTHIAZOLO[2,3 A]ISOINDOL 5(9BH) ONE; 4,5,6,7 TETRAHYDRO 5 METHYL 6 (3 METHYL 2 BUTENYL)IMIDAZO[4,5,1 JK][1,4]BENZODIAZEPINE 2(1H) THIONE; 9 CHLORO 4,5,6,7 TETRAHYDRO 5 METHYL 6 (3 METHYL 2 BUTENYL)IMIDAZO[4,5,1 JK][1,4]BENZODIAZEPINE 2(1H) THIONE; ALPHA ANILINOPHENYLACETAMIDE DERIVATIVE; ANTIVIRUS AGENT; BHAP DERIVATIVE; DIDANOSINE; EMTRICITABINE; IMIDAZO[2',3':6,5]DIPYRIDO[3,2 B:2',3' E][1,4]DIAZEPINE DERIVATIVE; L 737126; LAMIVUDINE; NEVIRAPINE; OXATHIIN CARBOXANILIDE DERIVATIVE; PHENYLETHYLTHIOUREATHIAZOLE; PYRROLOBENZODIAZEPINONE; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; S 2720; STAVUDINE; THIAZOLOBENZIMIDAZOLE DERIVATIVE; TSAO DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; UNIROYAL; VIRUS ENZYME; ZALCITABINE; ZIDOVUDINE;

EID: 0028120730     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(94)90001-9     Document Type: Article
Times cited : (217)

References (119)
  • 2
    • 0025837774 scopus 로고
    • Broad-spectrum anti-DNA virus and antiretrovirus activity of phosphonylmethoxyalkylpurines and -pyrimidines
    • (1991) Biochem Pharmacol , vol.42 , pp. 963-972
    • De Clercq1
  • 14
    • 0027278282 scopus 로고
    • Bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: Structure-activity relationships of novel substituted indole analogues and the identification of 1-[(5-methanesulfonamido-1H — indol — 2 — yl) — carbonyl] — 4 — [3[(1- methylethyl) -amino]pyridinyl]piperazine Monomethanesulfonate (U-90152S), a second-generation clinical candidate
    • (1993) J Med Chem , vol.36 , pp. 1505-1508
    • Romero1    Morge2    Genin3    Biles4    Busso5    Resnick6    Althaus7    Reusser8    Thomas9    Tarpley10
  • 24
    • 0026715578 scopus 로고
    • Imidazop[2',3':6,5]dipyrido[3,2-b:2',3'-e]-1,4-diazepines: Non-nucleoside HIV-1 reverse tran-scriptase inhibitors with greater enzyme affinity than nevirapine
    • (1992) Bioorg Med Chem Lett , vol.2 , pp. 1745-1750
    • Terrett1    Bojanic2    Merson3    Stephenson4
  • 33
    • 0027103626 scopus 로고
    • Common features in the interaction of tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one and -thione and 1-[(2-hydroxyethoxy)-methyl]-6-(phenylthio)thymine derivatives with the human immunodeficiency virus type 1 reverse transcriptase
    • (1992) Mol Pharmacol , vol.41 , pp. 963-968
    • Debyser1    Pauwels2    Baba3    Desmyter4    De Clercq5
  • 34
    • 0026773359 scopus 로고
    • Kinetics of inhibition of endogenous human immunodeficiency virus type 1 reverse transcription by 2′,3′-dideoxynucleoside 5′- triphosphate, tetrahydroimidazo—[4,5,1—jk][1,4] -benzodiazepin-2(1H)-thione, and 1-[(2-hydroxyeth-oxy)methyl]-6-(phenylthio)thymine derivatives
    • (1992) J Biol Chem , vol.267 , pp. 11769-11776
    • Debyser1    Vandamme2    Pauwels3    Baba4    Desmyter5    De Clercq6
  • 35
    • 0026724892 scopus 로고
    • Kinetics of inhibition of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase by the novel HIV-1-specific nucleoside analogue [2′,5′-bis-O-(tert-butyldimethylsilyl) — β — d — ribofuranosyl]-3'-spiro-5″-(4″- amino — 1″,2″ — oxathiole — (TSAO-T)
    • (1992) J Biol Chem , vol.267 , pp. 11831-11838
    • Balzarini1    Pérez-Pérez2    San-Félix3    Camarasa4    Bathurst5    Barr6    De Clercq7
  • 40
    • 0027447133 scopus 로고
    • HIV-1-specific RT inhibitors: Highly selective inhibitors of human immunodeficiency virus type 1 that are specifically targeted at the viral reverse transcriptase
    • (1993) Med Res Rev , vol.13 , pp. 229-258
    • De Clercq1
  • 41
    • 0024508058 scopus 로고
    • HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy
    • (1989) Science , vol.243 , pp. 1731-1734
    • Larder1    Darby2    Richman3
  • 44
    • 0026542755 scopus 로고
    • In vitro selection of variants of human immunodeficiency virus type 1 resistant to 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine
    • (1992) J Virol , vol.66 , pp. 12-19
    • Gao1    Gu2    Parniak3    Li4    Wainberg5
  • 45
    • 0027506940 scopus 로고
    • Generation of drug-resistant variants of human immunodeficiency virus type 1 by in vitro passage in increasing concentrations of 2',3'-dideoxycytidine and 2',3'-dideoxy-3'-thiacytidine
    • (1993) Antimicrob Agents Chemother , vol.37 , pp. 130-133
    • Gao1    Gu2    Hiscott3    Dionne4    Wainberg5
  • 46
    • 0027155374 scopus 로고
    • The same mutation that encodes low-level human immunodeficiency virus type 1 resistance to 2',3'-dideoxyinosine and 2', 3'-dideoxycytidine confers high-level resistance to the (−)enantiomer of 2',3'-dideoxy-3'-thiacytidine
    • (1993) Antimicrob Agents Chemother , vol.37 , pp. 1390-1392
    • Gao1    Gu2    Parniak3    Cameron4    Cammack5    Boucher6    Wainberg7
  • 47
    • 0024310253 scopus 로고
    • Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT)
    • (1989) Science , vol.246 , pp. 1155-1158
    • Larder1    Kemp2
  • 48
    • 0026565278 scopus 로고
    • Fifth mutation in human immunodeficiency virus type 1 reverse transcriptase contributes to the development of high-level resistance to zidovudine
    • 2nd Edn.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 1934-1938
    • Kellam1    Boucher2    Larder3
  • 55
    • 0027458760 scopus 로고
    • Sequence analysis of reverse transcriptase genes of zidovudine (AZT)-resistant and -sensitive human immunodeficiency virus type 1 strains
    • (1993) J Gen Virol , vol.74 , pp. 223-228
    • Sheehy1    Desselberger2
  • 61
    • 0027472841 scopus 로고
    • A single conservative amino acid substitution in the reverse transcriptase of human immunodeficiency virus-1 confers resistance to (+) — (5S) — 4,5,6,7 — tetrahydro-5-methyl-6-(3-methyl-2-butenyl)imidazo[4,5,1 — jk][1,4]benzodiazepin — 2 -(1H)thione (TIBO R82150)
    • (1993) Mol Pharmacol , vol.43 , pp. 11-16
    • Mellors1    Im2    Tramontano3    Winkler4    Medina5    Dutschman6    Bazmi7    Piras8    Gonzalez9    Cheng10
  • 63
    • 0027524005 scopus 로고
    • Human immunodeficiency virus type 1-specific [2′,5′-bis- O- (tert- butyldimethylsilyl)- β- d- ribofuranosyl]-3′- spiro- 5″- (4″- amino- 1″,2″- oxathiole- 2″, 2″- di-oxide)purine analogues show a resistance spectrum that is different from that of the human immunodeficiency virus type 1-sperific non-nucleoside analogues
    • (1993) Mol Pharmacol , vol.43 , pp. 109-114
    • Balzarini1    Velazquez2    San-Félix3    Karlsson4    Pérez-Pérez5    Camarasa6    De7
  • 64
    • 0027381149 scopus 로고
    • Human immunodeficiency virus type 1 drug-resistance patterns with different 1-(2-hydroxyethoxy)methyl-6-(phenyl-thio)thymine derivatives
    • (1993) Mol Pharmacol , vol.44 , pp. 694-701
    • Balzarini1    Karlsson2    De Clercq3
  • 68
    • 0027214433 scopus 로고
    • Treatment of human immunodeficiency virus type 1 (HIV-1)-infected cells with combiNatlons of HIV-1-specific inhibitors results in a different resistance pattern than does treatment with single-drug therapy
    • (1993) J Virol , vol.67 , pp. 5353-5359
    • Balzarini1    Karlsson2    Pérez-Pérez3    Camarasa4    Tarpley5    De Clercq6
  • 71
    • 3042814938 scopus 로고
    • HIV-1 strains selected for resistance against one particular class of HIV-1-specific reverse transcriptase inhibitors may retain sensitivity to other classes of HIV-1-specific inhibitors
    • (1993) Int Antiviral News , vol.1 , pp. 66-68
    • Balzarini1    Karlsson2    Camarasa3    De Clercq4
  • 72
    • 84908795005 scopus 로고    scopus 로고
    • Vandamme A-M, Debyser Z, Pauwels R, De Vreese K, Goubau P, Youle M, Gazzard B, Stoffels PA, Cauwenberg GF, Anné J, Andries K, Janssen PAJ, Desmyter J and De Clercq E, Characterization of HIV-1 strains isolated from patients treated with TIBO R82913. AIDS Res Hum Retroviruses, in press.
  • 83
    • 0026454435 scopus 로고
    • 3'-Azido-3'-deoxythymidine resistance suppressed by a mutation conferring human immunodeficiency virus type 1 resistance to nonnucleoside reverse transcriptase inhibitors.
    • (1992) Antimicrobial Agents and Chemotherapy , vol.36 , pp. 2269-2664
    • Larder1
  • 89
    • 0026357107 scopus 로고
    • 1 — β — D — Ribofuranosyl -1,2,4 — triazole — 3 — carboxa- mide (ribavirin) and 5-ethynyl-1-β-D-ribofuranosyl-imidazole-4-carbo (EICAR) markedly po-tentiate the inhibitory effect of 2′,3′-dideoxyinosine on human immunodeficiency virus in peripheral blood lymphocytes
    • (1991) Biochem Biophys Res Commun , vol.178 , pp. 563-569
    • Balzarini1    Lee2    Schols3    De Clercq4
  • 90
    • 0025880937 scopus 로고
    • Mechanism of the potentiating effect of ribavirin on the activity of 2',3'-dideoxyinosine against human immunodeficiency virus
    • (1991) J Biol Chem , vol.266 , pp. 21509-21514
    • Balzarini1    Lee2    Herdewijn3    De Clercq4
  • 98
    • 0027486945 scopus 로고
    • Convergent combination therapy can select viable multidrug-resistant HIV-1 in vitro
    • (1993) Nature , vol.365 , pp. 451-453
    • Larder1    Kellam2    Kemp3
  • 103
    • 0027509865 scopus 로고
    • HIV seroconversion after occupational exposure despite early prophylactic zidovudine therapy
    • Anonymous
    • (1993) Lancet , vol.341 , pp. 1077-1078
  • 104
    • 0027459081 scopus 로고
    • Quantitation of zidovudine-resistant human immunodeficiency virus type 1 in the blood of treated and untreated patients
    • 2nd Edn.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 25-29
    • Mohri1    Singh2    Ching3    Ho4
  • 114
    • 0026705125 scopus 로고
    • Incidence of zidovudine-resistant human immunodeficiency virus isolated from patients before, during, and after therapy
    • (1992) J Infect Dis , vol.166 , pp. 1139-1142
    • Land1    McGavin2    Lueas3    Birch4
  • 119
    • 0023489903 scopus 로고
    • Resumption of virus production after human immunodeficiency virus infection of T lymphocytes in the presence of azidothymidine
    • (1987) J Virol , vol.61 , pp. 3769-3773
    • Smith1    Brian2    Pagano3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.