Getting a grip on DNA recognition: structures of the basic region leucine zipper, and the basic region helix-loop-helix DNA-binding domains

Current Opinion in Structural Biology

Volumn 4, Issue 1, 1994, Pages 12-21

  Ellenberger, Tom ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC PROTEIN; LEUCINE ZIPPER PROTEIN; TRANSCRIPTION FACTOR;

BINDING SITE; CRYSTAL STRUCTURE; DNA CONFORMATION; DNA HELIX; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; REVIEW;

EID: 0028118685     PISSN: 0959440X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-440X(94)90054-X     Document Type: Article

References (84)

1. The X-Ray Structure of the GCN4 bZIP Bound to ATF/CREB Site DNA Shows the Complex Depends on DNA Flexibility
2. Recognition by Max of its Cognate DNA Through a Dimeric b/HLH/Z Domain
3. The GCN4 Basic Region Leucine Zipper Binds DNA as a Dimer of Uninterrupted a-Helices: Crystal Structure of the ProteinDNA Complex
4. Sequence-specific DNA Binding by a Short Peptide Dimer
5. Design of DNA binding peptides based on the Leucine Zipper motif
6. DNA-induced Increase in the α-helical Content of C/EBP and GCN4
7. Altered Protein Conformation on DNA Binding by Fos and Jun
8. Folding Transition in the DNA-binding Domain of GCN4 on Specific DNA Binding
9. The Solution Structure of a Lcucinc-Zipper Motif Peptide
10. Molecular Characterization of Helix-Loop-Helix Peptides
11. Folding Topology of the Disulfide-Bonded Dimeric DNA-Binding Domain of the Myogenic Determination Factor MyoD
12. High Affinity DNA-binding Myc Analogs: Recognition by an α-Helix
13. A Structural Taxonomy of DNA-Binding Domains
14. Transcription Factors: Structural Fami-lies and Principles of DNA Recognition
15. Mutations That Define the Optimal Half-site for Binding Yeast GCN4 Activator Pro tcin and Identify an ATF/CREB-like Repressor That Recognizes Similar DNA Sites
16. Scissors-Grip Model for DNA Recognition by a Family of Leucine Zipper Proteins
17. Predicted Structural Similarities of the DNA Binding Domains of c-Myc and Endonuclease Eco RI
18. Molecular Model for DNA Recognition by the Family of Basic-Helix-Loop-Helix-Zipper Proteins
19. Proposed Structure for the DNA-binding Domain of the Helix-Loop-Helix Family of Eukaryotic Gene Regulatory Proteins
20. X-ray Structure of the GCN4 Lcucinc Zipper, a Two-Strandcd, Parallel Coiled Coil
21. Structure of the Leucine Zipper
22. The Basic-Region Leucine-Zipper Family of DNA Binding Proteins
23. What is the Pitch of the a-helical Coiled Coil?
24. The Packing of a-helices Simple Coiled-coils
25. Dimcrization Specificity of the Leucine Zippcrcontaining bZIP Motif on DNA Binding: Prediction and Rational Design
26. The Role of Surface Contacts in Leucine Zipper Stability
27. Sequence Requirements for Coilcdcoils: Analysis with Lambda RepressorGCN4 Leucine Zipper Fusions
28. Leucine Zippers of fos, jun, and GCN4 Dictate Dimcrization Specificity and Thereby Control DNA Binding
29. The Leucine Repeat Motif in Fos Protein Mediates Complex Formation with Jun/AP-1 and Is Required for Transformation
30. Leucine Repeats and an Adjacent DNA Binding Domain Mediate the Formation of Functional cFoscJun Heterodimers
31. Role of the Conserved Leucines in the Leucine Zipper Dimerization Motif of Yeast GCN4
32. Non-leucine Residues in the Leucine Repeats of Fos and Jun Contribute to the Stability and Determine the Specificity of Dimerization
33. Mechanism of Specificity in the Fos-Jun Oncoprotein Heterodimer
34. Construction, Purification , and Characterization of a Hybrid Protein Comprising the DNA Binding Domain of the LexA Repressor and the Jun Leucine Zipper: A Circular Dichroism and Mutagenesis Study
35. Involvement of the Leucine Zipper Region in the Oligomerization and Transforming Activity of Human c-Myc Protein
36. Transcription Factor AP-4 Contains Multiple Dimetization Domains That Regulate Dimer Specificity
37. The Adenovirus Major Late Transcription Factor USF is a Member of the Helix-Loop-Helix Group of Regulatory Proteins and Binds to DNA as a Dimer
38. Max A Helix-loop-Helix Zipper Protein That Forms a Sequence-Specific DNA-binding Complex With Myc
39. A New Bind for Myc
40. The Leucine Zipper of TFE3 Dictates Helix-loop-helix Dimerization Specificity
41. TFEB Has DNA-binding and Oligomerization Properties of a Unique Helix-Loop-Helix/Leucine Zipper Family
42. Both the Helix-Loop-Helix and the Lcucine Zipper Motifs of c-Myc Contribute to Its Dimerization Specificity with Max
43. Functional Activity of Myogenic MR Proteins Requires Hetero-Oligomerization With E12/E474-like Proteins in Vivo
44. Intracellular Lcucine Zipper Interactions Suggest c-Myc Hetero-Oligomerization
45. Helix-loop-helix Proteins in the Regulation of Immunogobulin Gene Transcription
46. Transcriptional Activation by the Human cMyc Oncoprotein Requires Interaction with Max
47. Members of the USF Family of Helix-Loop Helix Proteins Bind DNA as Homo- as Well as Heterodimers
48. Association of Myn, the Murine Homolog of Max, With c-Myc Stimulates Methylation-sensitive DNA Binding and Ras Cotransforma-tion
49. Max: Functional Domains and Interaction with Myc
50. Oncogenic Activity of the c-Myc Protein Requires Dimerization with Max
51. Uracil Interference, a Rapid and General Method for Defining Protein-DNA Interactions Involving the 5-methyl Group of Thymincs: The GCN4-DNA Complex
52. Identification of an Amino Acid-Bast Contact in the GCN4-DNA Complex by Bromouracil-mediated Photocrosstinking
53. Highly Conserved Residues in the bZIP Domain of Yeast GCN4 Are Not Essential for DNA Binding
54. Mutations in the bZIP Domain of Yeast GCN4 That Alter DNA-binding Specificity
55. Identification of Three Residues in the Basic Regions of the bZIP Proteins GCN4, C/EBP and TAF-1 That Are Involved in Specific DNA Binding
56. The DNA Binding Specificity of the Basic Region of the Yeast Transcriptional Activator GCN4 Can Be Changed By Sub stitution of a Single Amino Acid
57. Adaptability at the Protein-DNA Interface Is an Important Aspect of Sequence Recognition by bZIP Proteins
58. Minimum Length of a Sequence-specific DNA Binding Peptide
59. Altered Specificity of DNA-binding Proteins with Transition Metal Dimerization Domains
60. Design of a Metallo-bZIP Protein That Discriminates Between CRE and API Target Sites: SeIcction Against API
61. Binding of Myc Proteins to Canonical and Noncanonical DNA Sequences
62. ADD1: a Novel Helix-Loop-Helix Transcription Factor Associated With Adipocyte Determination and Differentiation
63. Single Amino Acid Substitutions Alter Helix-Loop-Helix Protein Specificity for Bases Flanking the Core CANNTG Motif
64. Identification of Amino Acid-base Contacts in the MycDNA Complex by Site-specific Bromouracil-Mediated Photocrosslinking
65. Discrimination Between Related DNA Sites by a Single Amino Acid Residue of Myc-related Basic-Helix-Loop-Helix Proteins
66. A Point Mutation in the MyoD Basic Domain Imparts c-Myelike Properties
67. Differences and Similarities in DNA-binding Preferences of MyoD and E2A PRotcin Complexes Revealed by Binding Site Selection
68. Determination of the cMyc DNA-binding Site
69. Molecular Characterization of the GCN4-DNA Complex
70. Fos-Jun Hctcrodimers and Jun Homodimcrs Bend DNA in Opposite Orientations: Implication for Transcription Factor Coopcrativity
71. DNA Bending by Fos and Jun: The Flexible Hinge Model
72. Selective DNA Bending by a Variety of bZIP Proteins
73. Opposite Orientations of DNA Bending by c-Myc and Max
74. Myc/Max and Other Helix-Loop-Helix/Leucine Zipper Proteins Bend DNA Toward the Minor Groove
75. DNA Bending, Flexibility and Helical Repeat by Cyclization Kinetics
76. Cooperative Interaction of an Initiator-binding Transcription Initiation Factor and the Helix-Loop-Helix Activator USF
77. Functional Antagonism Between c Jun and MyoD Proteins: A Direct Physical Association
78. Interaction Cloning: Identification of a Helix-Loop-Helix Zipper Protein That Interacts With c-Fos
79. Acquisition of Myogenic Specificity by Replacement of Three Amino Acid Residues From MyoD Into E12
80. Fos and Jun Repress Transcriptional Activation by Myogenin and MyoD: the Amino Terminus of Jun Can Mediate Repression
81. Cyclic Amplification and Selection of Targets for Multicomponent Complexes: Myogenin Interacts With Factors Recognizing Binding Sites For Ba sic Helix-Loop-Helix, Nuclear Factor 1, Myocyte-specific Enhanccr-bindng Factor 2, and COMPI Factor
82. B: Interaction of Myogenic Factors and the Retinoblastoma Protein Mediates Muscle Cell Commitment and Differentiation
83. E1A mediated Inhibition of Myogenesis Correlates With a Direct Physical Interaction of E1A(12S) and Basic Helix-LoopHelix Proteins
84. Program to Produce Both Detailed and Schematic Plots of Protein Structures