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There have been recorded many examples of chiral Cu(D-and Rh(II)-catalyzed cyclopropanation of olefins with chiral diazoacetates in which the chirality of the catalyst is the dominating factor for the stereochemical course of this process. Compared to the use of the chiral Cu(I) catalysts, the catalyses with chiral Rh(II) complexes frequently exhibit significant levels of double stereodifferentiation. (a) For double asymmetric cyclopropanation with chiral Cu(I) catalysts, see: (i)
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There have been recorded many examples of chiral Cu(D-and Rh(II)-catalyzed cyclopropanation of olefins with chiral diazoacetates in which the chirality of the catalyst is the dominating factor for the stereochemical course of this process. Compared to the use of the chiral Cu(I) catalysts, the catalyses with chiral Rh(II) complexes frequently exhibit significant levels of double stereodifferentiation. (a) For double asymmetric cyclopropanation with chiral Cu(I) catalysts, see: (i) Aratani, T. Pure Appl. Chem. 1985, 57, 57.
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For double asymmetric cyclopropanation with chiral Rh(II) catalysts, see: (i)
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For double asymmetric cyclopropanation with chiral Rh(II) catalysts, see: (i) Doyle, M. P., Brandes, B. D., Kazala, A. P., Pieters, R. J., Jarstfer, M. B., Watkins, L. M., Eagle, C. T. Tetrahedron Lett. 1990, 31, 6613.
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