Invadopodia promote proteolysis of a wide variety of extracellular matrix proteins

Journal of Cellular Physiology

Volumn 158, Issue 2, 1994, Pages 299-308

  Kelly, Thomas ^a,b   Mueller, Susette C ^a   Yeh, Yunyun ^a   Chen, Wen‐Tien ^a  

^a GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 4; FIBRONECTIN; LAMININ A; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL TRANSFORMATION; CHICKEN; EMBRYO; EXTRACELLULAR MATRIX; FIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; ROUS SARCOMA ONCOVIRUS;

ANIMAL; CELL MEMBRANE; CELL TRANSFORMATION, VIRAL; CHICK EMBRYO; ENDOPEPTIDASES; EXTRACELLULAR MATRIX PROTEINS; FIBROBLASTS; MOLECULAR WEIGHT; PEPTIDE HYDROLASES; SARCOMA VIRUSES, AVIAN; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

ANIMALIA; GALLUS GALLUS; ONCOVIRINAE; ROUS SARCOMA VIRUS;

EID: 0028115933     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.1041580212     Document Type: Article

References (34)

1. Comparisons of evolutionarily distinct fibronectins: Evidence for the origin of plasma and fibroblast cellular fibronectins from a single gene
2. Extracellular Matrix Degradation
3. A 170‐kDa membrane‐bound protease is associated with the expression of invasiveness by human malignant melanoma cells
4. Transformation‐dependent activation of urokinase‐type plasminogen activator by a plasminindependent mechanism: Involvement of cell surface membranes
5. Phase separation of integral membrane proteins in Triton X‐114 solution
6. Focal adhesions: Transmembrane junctions between the extracellular matrix and the cytoskeleton
7. Fibronectin‐degrading proteases from the membranes of transformed cells
8. Isolation and characterization of a 70‐kDa metalloprotease (gelatinase) that is elevated in Rous sarcoma virus‐transformed chicken embryo fibroblasts
9. Proteolytic activity of specialized surface protrusions formed at rosette contact sites of transformed cells
10. Expression of transformation‐associated protease(s) that degrade fibronectin at cell contact sites
11. Local degradation of fibronectin at sites of expression of the transforming gene product pp60src
12. Regulation of fibronectin receptor distribution by transformation, exogenous fibronectin, and synthetic peptides
13. Altered distributions of the cytoskeletal proteins vinculin and alpha‐actinin in cultured fibroblasts transformed by Rous sarcoma virus
14. The extracellular matrix of normal chicken embryo fibroblasts: Its effect on transformed chicken fibroblasts and its proteolytic degradation by the transformants
15. Linkage of extracellular plasminogen activator to the fibroblast cytoskeleton: Colocalization of cell surface urokinase with vinculin
16. Electrophoretic analysis of plasminogen activators in polyacrylamide gels containing sodium dodecyl sulfate and copolymerized substrates
17. Behavior of cells seeded in isolated fibronectin matrices
18. Cleavage of structural proteins during assembly of the head of bacteriophage T4
19. Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation
20. Masking of extracellular collagen and fibronectin during matrix formation by cultured embryonic fibroblasts
21. Rous sarcoma virus‐transformed fibroblasts and cells of monocytic origin display a peculiar dot‐like organization of cytoskeletal proteins involved in microfilament‐membrane interactions
22. Biology and biochemistry of proteinases in tumor in vasion
23. r 72,000 matrix metalloproteinase at cell surface invadopodia
24. Cellular invasion into matrix beads: Localization of beta 1 integrins and fibronectin to the invadopodia
25. Tyrosine phosphorylation of membrane proteins mediates cellular invasion by transformed cells
26. Mechanism of the decrease in the major cell surface protein of chick embryo fibroblasts after transformation
27. Ultrastructural ocalization of plasma membrane‐associated urokinase‐type plasminogen activator at focal contacts
28. Prourokinase activation on the surface of human rhabdomyosarcoma cells: Localization and inactivation of newly formed urokinase‐type plasminogen activator by recombinant class 2 plasminogen activator inhibitor
29. Serine protease and metallo protease cascade systems involved in pericellular proteolysis
30. Cell‐associated plasminogen activation: Regulation and physiological functions
31. Alpha‐actinin‐containing aggregates in transformed cells are highly dynamic structures
32. An anticatalytic monoclonal antibody to avian plasminogen activator: Its effect on behavior of RSV‐transformed chick fibroblasts
33. Rous sarcoma virus‐transformed fibroblasts adhere primarily at discrete protrusions of the ventral membrane called podosomes
34. Immunological characterization of a major transformation‐sensitive fibroblast cell surface glycoprotein: Localization, redistribution, and role in cell shape