RH-3421, a potent dihydropyrazole insecticide, inhibits depolarization-stimulated rises in free [Ca2+] and 45Ca2+ uptake in mammalian synaptosomes

Comparative Biochemistry and Physiology. Part C: Comparative

Volumn 108, Issue 3, 1994, Pages 307-310

  Zhang, Aiguo ^a   Nicholson, Russell A ^a  

^a SIMON FRASER UNIVERSITY   (Canada)

Author keywords

Brain; Dihydropyrazole; Inhibition; Ionic calcium; Mammal; RH 3421; Synaptosomes

Indexed keywords

CALCIUM; CALCIUM 45; CALCIUM CHANNEL; COBALT; INSECTICIDE; POTASSIUM ION; PYRAZOLE DERIVATIVE; RH 3421; TETRODOTOXIN; UNCLASSIFIED DRUG; VERATRIDINE;

ANIMAL TISSUE; ARTICLE; BRAIN SYNAPTOSOME; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPOLARIZATION; DRUG MECHANISM; MOUSE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL;

ANIMAL; CALCIUM; CALCIUM ISOTOPES; INSECTICIDES; MEMBRANE POTENTIALS; MICE; PHENYLUREA COMPOUNDS; PYRAZOLES; SODIUM CHANNELS; SUPPORT, NON-U.S. GOV'T; SYNAPTOSOMES; TETRODOTOXIN; VERATRIDINE;

EID: 0028114563     PISSN: 07428413     EISSN: None     Source Type: Journal    
DOI: 10.1016/0742-8413(94)00029-A     Document Type: Article

References (11)

1. 3H] batrachotoxin A 20-α-benzoate binding to mouse brain sodium channels by the dihydropyrazole insecticide RH-3421
2. RH-3421, an insecticidal dihydropyrazole, inhibits sodium channel-dependent sodium uptake in mouse brain preparations
3. A rapid method for isolation of synaptosomes on percoll gradients
4. A new class of insecticidal dihydropyrazoles
5. 2+ by neurotoxic organometals: distinctive mechanisms
6. 2+: reversal by dihydropyridine calcium channel antagonists
7. Insecticidal dihydropyrazoles antagonize the depolarizing action of veratridine in mammalian synaptosomes as measured with a voltage-sensitive dye
8. 3H] GABA from nerve terminals isolated from mammalian cerebral cortex
9. 2+ levels in cerebrocortical synaptosomes of rats
10. The dihydropyrazole RH-5529 blocks voltage-sensitive calcium channels in mammalian synaptosomes