Differential inhibition of foot tapping and chromodacryorrhoea in gerbils by CNS penetrant and non-penetrant tachykinin NK1 receptor antagonists

European Journal of Pharmacology

Volumn 265, Issue 3, 1994, Pages 179-183

  Rupniak, Nadia M J ^a   Williams, Angela R ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

(Gerbil); Chromodacryorrhoea; CNS (central nervous system) penetration; Foot tapping; Tachykinin NK1 receptor

Indexed keywords

3 (2 METHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; 5 AMINOVALERYLSUBSTANCE P [7-11][9 PROLINE 10 (N METHYLLEUCINE)]; L 743310; NEUROKININ 1 RECEPTOR; NEUROKININ 1 RECEPTOR AGONIST; NEUROKININ 1 RECEPTOR ANTAGONIST; TACHYKININ DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG PENETRATION; DRUG SELECTIVITY; ENANTIOMER; FEMALE; GERBIL; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LACRIMATION; MALE; NONHUMAN; PRIORITY JOURNAL;

ANALYSIS OF VARIANCE; ANIMAL; BEHAVIOR, ANIMAL; BIOLOGICAL ASSAY; BLOOD-BRAIN BARRIER; FEMALE; GERBILLINAE; INJECTIONS, INTRAVENOUS; INJECTIONS, INTRAVENTRICULAR; MALE; PEPTIDE FRAGMENTS; RECEPTORS, NEUROKININ-1; SUBSTANCE P; TEARS;

EID: 0028113481     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(94)90430-8     Document Type: Article

References (17)

1. 1 receptors by use of the non-peptide antagonist, CP-96,345
2. 1 receptor antagonist, CP-99,994, in ferrets
3. 1 receptor antagonists: comparison of behavioural and electrophysiological tests
4. Increased plasma catecholamines and locomotor activity induced by centrally administered substance P in guinea-pigs
5. 1 receptor activation in gerbils
6. Behavioural effects of tachykinins and related peptides
7. Modulation of the rat mesolimbic dopamine pathway by neurokinins
8. 1 receptor antagonists is mediated centrally in the ferret
9. Species differences in affinities of non-peptide antagonists for substance P receptors
10. Characterisation of the tachykinin-induced hindlimb thumping response in gerbils
11. 1 receptor antagonist, on facilitation of a nociceptive spinal flexion reflex in the rat
12. Pharmacology of CP-99,994; a nonpeptide antagonist of the tachykinin neurokinin-1 receptor
13. ‘Foot-stomping’ in the gerbil: rewarding brain stimulation, sexual behaviour and foot shock
14. 1 receptor antagonist CP-99,994 in guinea-pigs
15. 3 tachykinin receptor agonist senktide elicits 5-HT-mediated behaviour following central or peripheral administration in mice and rats
16. 1 receptor antagonist CP-99,994 attenuates cisplatin induced emesis in the ferret
17. 1 receptor antagonists to inhibit emesis induced by the cytotoxic chemotherapeutic agent cisplatin in ferrets