BiP (GRP78), an essential hsp70 resident protein in the endoplasmic reticulum

Experientia

Volumn 50, Issue 11-12, 1994, Pages 1012-1020

  Haas, I G ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

ER degradation; ER translocation; folding and assembly of polypeptide chains; hsp70 structure

Indexed keywords

HEAT SHOCK PROTEIN; POLYPEPTIDE;

CELL VIABILITY; ENDOPLASMIC RETICULUM; EUKARYOTIC CELL; NONHUMAN; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN STRUCTURE; PROTEIN TRANSPORT; REVIEW;

ADENOSINE TRIPHOSPHATE; ANIMAL; CARRIER PROTEINS; ENDOPLASMIC RETICULUM; HEAT-SHOCK PROTEINS 70; HUMAN; IMMUNOGLOBULINS, HEAVY-CHAIN; MOLECULAR CHAPERONES; PHOSPHORYLATION; PROTEIN FOLDING; SUPPORT, NON-U.S. GOV'T;

EUKARYOTA;

EID: 0028110180     PISSN: 00144754     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/BF01923455     Document Type: Review

References (93)

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9. A Sec63p-BiP complex from yeast is required for protein translocation in a reconstituted proteoliposome
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14. Translocation of ATP into the lumen of rough endoplasmic reticulum drived vesicles and its binding to luminal proteins including BiP (GRP 78) and GRP 94
15. Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase
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24. Interconversion of three differentially modified and assembled forms of BiP
25. The immunoglobulin-binding protein in vitro autophosphorylation site maps to a threonine within the ATP binding cleft but is not a detectable site of in vivo phosphorylation
26. Mutations within the nucleotide binding site of immunoglobulin-binding protein inhibit ATPase activity and interfere with release of immunoglobulin heavy chain
27. Expression of wild-type and mutant forms of influenza hemagglutinin: The role of folding and intracellular transport
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38. Atomic structure of the actin: DNase I complex
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40. Hormonal regulations of thyroglobulin export from the endoplasmic reticulum of cultured thyrocytes
41. Transient aggregation of nascent thyroglobulin in the endoplasmic reticulum: relationship to the molecular chaperone, BiP
42. Interaction of BiP with newly synthesized immunoglobulin light chain molecules: cycles of sequential binding and release
43. The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins
44. Different conformations for the same polypeptide bound to chaperones DnaK and GroEL
45. Coordinated regulation of a set of genes by glucose and calcium ionophores in mammalian cells
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51. The ERD2 gene determines the specificity of the luminal ER protein retention system
52. Competitive inhibition of a set of endoplasmic reticulum protein genes (GRP78, GRP94, and ERp72) retards cell growth and lowers viability after ionophore treatment
53. The 170-kDa glucose-regulated stress protein is an endoplasmic reticulum protein that binds immunoglobulin
54. The heat-shock proteins
55. The secretory pathway is normal in dithiothreitol-treated cells, but disulfide-bonded proteins are reduced and reversibly retained in the endoplasmic reticulum
56. Association of transport-defective light chains with immunoglobulin heavy chain binding protein
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58. DnaK as a thermometer: threonine-199 is site of autophosphorylation and is critical for ATPase activity
59. The endoplasmic reticulum stress protein GRP94, in addition to BiP, associates with unassembled immunoglobulin chains
60. The two mammalian mitochondrial stress proteins, grp 75 and hsp 58, transiently interact with newly synthesized mitochondrial proteins
61. A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleus
62. A 22 bp cis-acting element is necessary and sufficient for the induction of the yeast KAR2 (BiP) gene by unfolded proteins
63. An Hsp 70-like protein in the ER: identity with the 78 kd glucose-regulated protein and immunoglobulin heavy chain binding protein
64. A C-terminal signal prevents secretion of luminal ER proteins
65. Different roles of individual N-linked oligosaccharide chains in folding, assembly, and transport of the simian virus 5 hemagglutinin-neuraminidase
66. Intracellular maturation and transport of the SV5 type II glycoprotein hemagglutinin-neuraminidase: specific and transient association with GRP78-BiP in the endoplasmic reticulum and extensive internalization from the cell surface
67. Analysis in vivo of GRP78-BiP/substrate interactions and their role in induction of the GRP78-BiP gene
68. Binding protein BiP is required for translocation of secretory proteins into the endoplasmic reticulum in Saccharomyces cerevisiae
69. Luminal proteins of the mammalian endoplasmic reticulum are required to complete protein translocation
70. An essential member of the HSP70 gene family of Saccharomyces cerevisiae is homologous to immunoglobulin heavy chain binding protein
71. IRE1 encodes a putative protein kinase containing a membrane-spanning domain and is required for inositol phototrophy in Saccharomyces cerevisiae
72. S. cerevisiae encodes an essential protein homologous in sequence and function to mammalian BiP
73. Stch encodes the ‘ATPase’ core of a microsomal stress 70 protein
74. Speculations on the functions of the major heat shock and glucose-regulated proteins
75. Infection with paramyxoviruses stimulates synthesis of cellular polypeptides that are also stimulated in cells transformed by Rous sarcoma virus or deprived of glucose
76. A hypothetical model for the peptide binding domain of hsp70 based on the peptide binding domain of HLA
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78. Polypeptide chain binding proteins: catalysts of protein folding and related processes in cells
79. Sec61p and BiP directly facilitate polypeptide translocation into the ER
80. Modulation of the phosphorylation of glucose-regulated protein, GRP78, by transformation and inhibition of glycosylation
81. DnaK, DnaJ and GrpE form a cellular chaperone machinery capable of repairing heat-induced protein damage
82. Eukaryotic DnaJ homologs and the specificity of Hsp70 activity
83. Interconversion of GRP78/BiP. A novel event in the action of Pasteurella multocida toxin, bombesin, and platelet-derived growth factor
84. Loss of BiP/GRP78 function blocks translocation of secretory proteins in yeast
85. The NH2-terminal 108 amino acids of the Escherichia coli DnaJ protein stimulate the ATPase activity of DnaK and are sufficient for λ-replication
86. Flux of the paramyxovirus hemagglutinin-neuraminidase glycoprotein through the endoplasmic reticulum activates transcription of the GRP78-BiP gene
87. Analysis of the glycosylation and phosphorylation of the alpha-subunit of the lysosomal enzyme, beta-hexosaminidase A, by site-directed mutagenesis
88. Biochemical characterization of the mammalian stress proteins and identification of two stress proteins as glucose- and Ca2+-ionophore-regulated proteins
89. Rapid purification of mammalian 70.000-dalton stress proteins: affinity of the proteins for nucleotides
90. A region of the C-terminal portion of the human transferrin receptor contains an asparagine-linked glycosylation site critical for receptor structure and function
91. Site-directed removal of N-glycosylation sites in the bovine cation-dependent mannose-6-phosphate receptor: effects on ligand binding, intracellular targetting and association with binding immunoglobulin protein